[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641142":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":37,"locations":31,"responsibleParty":48,"collaborators":52,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":31,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":31,"enrollmentInfo":69,"targetDuration":31,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":82,"whyStopped":31,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":31},{"fullName":5,"class":6},"University of Portsmouth","OTHER",[8,16,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Placebo will include the 20g nitrate placebo from above and 5g of maltodextrin (100% Maltodextrin Carbs, myprotein, UK) which will also be added to 305 mL water.",[13,14,15],"Dietary Supplement: taurine","Dietary Supplement: Beetroot and taurine","Dietary Supplement: Placebo",{"label":17,"type":18,"description":19,"interventionNames":20},"Taurine","ACTIVE_COMPARATOR","The taurine supplement will be administered as a 5g (100% taurine powder, myprotein, UK) dose. To taste match the beetroot arm we will use a nitrate depleted powder. The placebo contained 1.6% nitrate (180 mg nitrate; Bio-gen Extracts Private Limited, Karnataka, India). The servings contained 13.33g of nitrate depleted beetroot powder. The remaining 6.67g comprised a sweetener (stevia), flavour (watermelon) and flavouring agents (malic \\& citric acid). The beetroot powders were prepared by manipulating the processing control parameters (extraction time and temperature) during extract preparation to ensure precise nitrate concentration across the different conditions, particularly for the placebo. Specifically, raw beetroot was extracted with water for 1 h at \\>90°C with the residue obtained from the first extraction processed to obtain the low nitrate grade material. The NO3- content of beetroot powders were determined by treating the samples with a salicylic acid-sulphuric acid mixture",[13,15],{"label":22,"type":18,"description":23,"interventionNames":24},"Beetroot and Taurine","20g of formulated beetroot power containing \\~6% nitrate (800mg NO3-; TruBeet; Bio-gen Extracts Private Limited). The servings contained 13.33g of the formulated beetroot powder. The remaining 6.67g comprised a sweetener (stevia), flavour (watermelon) and flavouring agents (malic \\& citric acid) and 5g (100% taurine powder, myprotein, UK) of taurine will also be added to 305mL water prior to ingestion.",[14],[26,32,35],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DIETARY_SUPPLEMENT","taurine","The taurine supplement will be administered as a 5g (100% taurine powder, myprotein, UK) dose. To taste match the beetroot arm we will use a nitrate depleted powder. The placebo contained 1.6% nitrate (180 mg nitrate; Bio-gen Extracts Private Limited, Karnataka, India). The servings contained 13.33g of nitrate depleted beetroot powder. The remaining 6.67g comprised a sweetener (stevia), flavour (watermelon) and flavouring agents (malic \\& citric acid). The beetroot powders were prepared by manipulating the processing control parameters (extraction time and temperature) during extract preparation to ensure precise nitrate concentration across the different conditions, particularly for the placebo. Specifically, raw beetroot was extracted with water for 1 h at \\>90°C with the residue obtained from the first extraction processed to obtain the low nitrate grade material. The NO3- content of beetroot powders were determined by treating the samples with a salicylic acid-sulphuric acid mixture,",[9,17],null,{"type":27,"name":33,"description":23,"armGroupLabels":34,"otherNames":31},"Beetroot and taurine",[22,9],{"type":27,"name":9,"description":11,"armGroupLabels":36,"otherNames":31},[9,17],[38,43],{"name":39,"role":40,"phone":41,"phoneExt":31,"email":42},"Daniel Piccolo, PhD","CONTACT","+44","daniel.piccolo@port.ac.uk",{"name":44,"role":40,"phone":45,"phoneExt":46,"email":47},"Ant I Shepherd, PhD","+44239284","5289","ant.shepherd@port.ac.uk",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Ant Shepherd","Dr. Ant Shepherd (PhD) Associate Professor in Clinical Exercise Physiology",[53,55,58],{"name":54,"class":6},"Swansea University",{"name":56,"class":57},"Portsmouth Hospitals NHS Trust","OTHER_GOV",{"name":59,"class":6},"University of Southampton","100641142","taurine-and-nitrate-supplementation-on-thermoregulatory-in-t2dm-100641142",false,"NCT07656051","Taurine and Nitrate Supplementation on Thermoregulatory in T2DM","The Effect of Taurine and Nitrate Supplementation on Thermoregulatory Responses in People With Type 2 Diabetes Mellitus.","Inclusion Criteria:\n\n* Male or female (post-menopausal) aged 35 years or above.\n* Diagnosed with T2DM as defined by the WHO (HbA1c ≥48 mmol\u002Fmol).\n* Willing and able to give informed consent for participation in the study.\n* Able to understand and fully cooperate with the study protocol.\n\nExclusion Criteria:\n\n* Severe peripheral neuropathy (to the point to which they cannot sense temperature)\n* Uncontrolled hypertension (≥180 systolic \u002F 100 diastolic)\n* Significant renal impairment (eGFR \\\u003C 30)\n* Diagnosed anhidrosis\n* Taking any medication which may interfere with data interpretation or safety\n* Who have had a myocardial infarction or cerebrovascular event\n* Any cardiac abnormalities which restrict hard exercise\n* Any allergies to the ingredients used in the supplements\n* BMI \\>40\n* Current smokers or who have stopped within 3 months\n* Unable to understand and\u002For fully cooperate with the study protocol\n* Any serious medical condition which would interfere with data interpretation or safety will be excluded from participation.\n* Open wounds\n* Skin ulcerations (that would interfere with data collection and interpretation or safety)\n* Eczema (that would interfere with data collection and interpretation or safety)\n* Pre-existing postural hypertension\n* Existing cardiac diseases (identified during screening)\n* Currently heat acclimated (repeated exposure to hot environments ≥3 sessions in the last 14-21 days)\n* Prior heat related illness","ALL","35 Years",{"count":70,"type":71},18,"ESTIMATED","INTERVENTIONAL",[74],"NA","Anthropogenic warming is increasing the frequency and intensity of extreme heat events. Elevated temperatures raise the risk of mortality and hospital admissions, particularly among people with chronic illnesses such as type 2 diabetes mellitus (T2DM). Globally, around 530 million people live with T2DM , and in the United Kingdom nearly six million are affected, creating a substantial population vulnerable to heat related illness.\n\nPeople with T2DM are at heightened risk of cardiovascular disease, which can impair cardiac output, a key component of thermoregulation, as it supports increased skin blood flow for heat dissipation. T2DM also attenuates eccrine sweat gland function, peripheral vasodilation, reducing evaporative cooling capacity. These physiological constraints highlight the need for effective strategies to improve heat tolerance in this group.\n\nRecent evidence shows that exogenous taurine supplementation can enhance sweating in healthy individuals, potentially improving heat loss. This study will examine whether acute taurine supplementation, alone or combined with beetroot, can limit rises in core temperature in people with T2DM during an acute extreme heat exposure.",[77],"Type 2 Diabetes",[79,28,80,81],"climate","nitrate","heat","NOT_YET_RECRUITING","2026-06-12",{"date":85,"type":86},"2026-06-18","ACTUAL",{"date":88,"type":71},"2026-06-01",{"date":90,"type":71},"2028-04-01",{"name":5,"class":6}]