[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584966":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":21,"centralContacts":31,"locations":41,"responsibleParty":64,"collaborators":36,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":36,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":36,"maxAge":36,"enrollmentInfo":74,"targetDuration":36,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":91,"overallStatus":44,"whyStopped":36,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Heinrich-Heine University, Duesseldorf","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"TTE, TEE and MRI after TAVR","Each study patient will undergo transthoracic echocardiography, transesophageal echocardiography, and cardiac magnetic resonance imaging following transcatheter aortic valve replacement.",[12],"Diagnostic Test: transthoracic echocardiography",[14],{"type":15,"name":16,"description":10,"armGroupLabels":17,"otherNames":18},"DIAGNOSTIC_TEST","transthoracic echocardiography",[9],[19,20],"Transoesophageal echocardiography","cardiac magnetic resonance imaging",[22,26,29],{"name":23,"affiliation":24,"role":25},"Malte Kelm, Prof.","Division of Cardiology, Pulmonary Disease and Vascular Medicine","STUDY_CHAIR",{"name":27,"affiliation":24,"role":28},"Tobias Zeus, Prof.","STUDY_DIRECTOR",{"name":30,"affiliation":24,"role":28},"Kathrin Klein, Dr. med.",[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Tobias Zeus, Prof","CONTACT","0211 81 18800",null,"zeus@med.uni-duesseldorf.de",{"name":30,"role":34,"phone":39,"phoneExt":36,"email":40},"0211 81 08252","kathrin.klein@med-uni-duesseldorf.de",[42],{"facility":43,"status":44,"city":45,"state":36,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf","RECRUITING","Düsseldorf","40225","Germany","DE",{"type":50,"coordinates":51},"Point",[52,53],6.77927,51.22319,{"lat":53,"lon":52},[56,58,61],{"name":27,"role":34,"phone":57,"phoneExt":36,"email":37},"0211 81 18801",{"name":59,"role":34,"phone":39,"phoneExt":36,"email":60},"Kathrin Klein, MD","kathrin.klein@med.uni-duesseldorf.de",{"name":62,"role":63,"phone":36,"phoneExt":36,"email":36},"Ayse Sedef Ceylan, Dr. med.","PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100584966","tavr-the-impact-of-prothesis-positioning-on-valvular-and-coronary-hemodynamics-100584966",false,"NCT06896227","TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics","Transcatheter Aortic Valve Implantation (TAVR): The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics","Inclusion Criteria\n\n\\- Patients who have undergone transfemoral transcatheter aortic valve replacement (TAVR).\n\nExclusion Criteria\n\n* Any access route other than transfemoral.\n* Valve-in-valve procedures.\n* History of prior bioprosthetic valve implantation.\n* Presence of pacemaker, implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy (CRT) system.\n* Diagnosis of liver cirrhosis.\n* Esophageal disorders, including but not limited to esophageal varices.\n* Thrombocytopenia or coagulation disorders.\n* Any medical or psychiatric condition (e.g., dementia, alcoholism, or substance abuse) that may impair the ability to provide informed consent or interfere with study procedures, including follow-up visits.","ALL",{"count":75,"type":76},100,"ESTIMATED","INTERVENTIONAL",[79],"NA","The aim of this clinical study is to learn more about the effects of TAVR-prosthesis positioning on hemodynamics and the coronary arteries.\n\nThe main questions it aims to answer are:\n\n1. Does the cardiac magnetic resonance imaging and the echocardiography imaging provide an equivalent alternative to the computer tomography which is the state of the art in evaluating commissural alignment?\n2. What effect does the position of the valve on the annular level have, especially its symmetrical and commissural position, on valvular and aortic blood flow characteristics?\n3. What is the influence of symmetrical position and the presence of a commissural alignment on the coronary flow after transcatheter aortic valve replacement?",[82,83,84,85,86,87,88,89,90],"Transcatheter Aortic Valve Replacement","Transcatheter Aortic Valve Implantation","Commissural Alignment","Commissural Misalignment","Symmetry","Prothesis Positioning","Prosthesis Durability","Aortic Valve Stenosis","Aortic Valve Disease",[92,93,94,86,95,96,97,98],"TAVR","TAVI","Commissural alignment","Prothesis positioning","cMRI","4D Flow","TEE","2025-03-19",{"date":101,"type":102},"2025-03-26","ACTUAL",{"date":104,"type":102},"2024-10-22",{"date":106,"type":76},"2025-12-31",{"name":5,"class":6},1]