[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559284":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":75,"collaborators":77,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":9,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":24,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Northern California Institute of Research and Education","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TRAIN-Vets","EXPERIMENTAL","TRAIN-Vets is an 8-month intervention with aquatic-based exercise training and cognitive training combined with personalized dementia risk factor reduction sessions. This intervention entails 6 months of thrice-weekly aquatic-based exercise training at Veterans Affairs Palo Alto Health Care System (VAPAHCS). After completion of the 6-months of exercise training, Veterans in this condition will participate in 2 months of weekly structured on-line cognitive training focused on improvement of executive function and attention based out of the San Francisco Veterans Affairs Health Care System (SFVAHCS). Concurrently, Veterans in TRAIN-Vets will also participate virtually in personalized risk factor reduction sessions based at SFVAHCS focused on other risk factors and symptoms.",[13],"Behavioral: TRAIN-Vets",{"label":15,"type":6,"description":16,"interventionNames":17},"Health Education Control","The Health Education Control (HEC) receives mailed educational materials about brain health and dementia risk factor reduction over 8 months, as well as regular contact with study staff.",[18],"Behavioral: Health Education Control",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","The TRAIN-Vets intervention entails 6 months of thrice-weekly aquatic-based exercise training at Veterans Affairs Palo Alto Health Care System (VAPAHCS). After completion of the 6-months of exercise training, Veterans in this condition will participate in 2 months of weekly structured on-line cognitive training focused on improvement of executive function and attention based out of the San Francisco Veterans Affairs Health Care System (SFVAHCS). Concurrently, Veterans in TRAIN-Vets will also participate virtually in personalized risk factor reduction sessions based at SFVAHCS focused on other risk factors and symptoms.",[9],null,{"type":21,"name":15,"description":16,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"affiliation":30,"role":31},"Kristine Yaffe, MD","University of California, San Francisco","PRINCIPAL_INVESTIGATOR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Carrie Peltz, PhD","CONTACT","415-221-4810","3286","carrie.peltz2@va.gov",{"name":40,"role":35,"phone":36,"phoneExt":37,"email":41},"Julia Cheunkarndee","julia.cheunkarndee@ncire.org",[43,63],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"VA Palo Alto Health Care System","RECRUITING","Palo Alto","California","94304-1207","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-122.14302,37.44188,{"lat":55,"lon":54},[58],{"name":59,"role":35,"phone":60,"phoneExt":61,"email":62},"Jennifer K Fairchild, PhD","650-493-5000","63432","JenniferKaci.Fairchild@va.gov",{"facility":64,"status":45,"city":65,"state":47,"zip":66,"country":49,"countryCode":50,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"San Francisco VA Health Care System","San Francisco","94121",{"type":52,"coordinates":68},[69,70],-122.41942,37.77493,{"lat":70,"lon":69},[73,74],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":29,"role":31,"phone":24,"phoneExt":24,"email":24},{"type":76,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[78,81],{"name":79,"class":80},"San Francisco Veterans Affairs Medical Center","FED",{"name":44,"class":80},"100559284","tbi-rehabilitation-and-activation-in-veterans-100559284",false,"NCT06562127","TBI Rehabilitation and Activation in Veterans","TBI Rehabilitation and Activation in Veterans (TRAIN-Vets)","Inclusion Criteria:\n\n* Veteran, age 50-89 years\n* History (more than 6 months post injury) of mild or moderate TBI defined by the Ohio State University TBI Identification Method and DOD\u002FVA Clinical Practice Guidelines for Definition of TBI\n* Sufficient vision and hearing to allow cognitive testing\n* Willingness to participate in water-based exercise program + cognitive training program for eight months\n* Approval of primary medical provider to participate in a water-based exercise program\n* Subjective cognitive complaints as evidenced by self-report\n* English proficiency to allow for cognitive testing\n* Internet connected device to participate in testing and cognitive training\n\nExclusion Criteria:\n\n* Current severe and unstable psychiatric disorder\n* Diagnosis of dementia, Montreal Cognitive Assessment score less than 18, or delirium\n* TBI within the past 6 months\n* Acute illness or unstable chronic illness\n* Current severe cardiac disease\n* Severe TBI or open head injury\n* Inability to exercise consistently\n* Inability to read, verbalize understanding, and voluntarily sign the Informed Consent","ALL","50 Years","89 Years",{"count":93,"type":94},120,"ESTIMATED","INTERVENTIONAL",[97],"NA","This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older Veterans with a history of TBI and subjective cognitive complaints will be enrolled and randomly assign to either the TRAIN-Vets intervention (consisting of aquatic-based exercise training, cognitive training, and lifestyle coaching) or the Health Education Control, where they will receive educational materials about brain health and healthy lifestyles.",[100],"Traumatic Brain Injury",[102,103,104,105,106],"Cognition","Cognitive training","Physical exercise","Head injury","Traumatic brain injury","2025-05-14",{"date":109,"type":110},"2025-05-16","ACTUAL",{"date":112,"type":110},"2025-05-12",{"date":114,"type":94},"2028-02",{"name":5,"class":6},2]