[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625966":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":132,"collaborators":26,"id":134,"slug":135,"hasResults":136,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":136,"sex":142,"minAge":143,"maxAge":144,"enrollmentInfo":145,"targetDuration":26,"studyType":148,"phases":149,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":155,"whyStopped":26,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":165},{"fullName":5,"class":6},"Centre Hospitalier Henri Laborit","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"tDCS","SHAM_COMPARATOR","These patients will only receive tDCS",[13],"Procedure: tDCS session",{"label":15,"type":16,"description":17,"interventionNames":18},"tDCS + symptom provocation","ACTIVE_COMPARATOR","These patients will experience symptom provocation followed with tDCS",[13,19],"Behavioral: symptom provocation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","tDCS session","An active bifocal tDCS delivered through a CE-certified stimulator. The bifocal montage consists of an anodal electrode over the right orbitofrontal cortex (OFC) and a cathodal electrode over the supplementary motor area (SMA), with 5X5 cm electrod. Stimulation intensity is set at 2 mA, with a 30-minute session duration, including 30-second ramp-up and ramp-down periods.",[9,15],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","symptom provocation","A 3-5 minutes personalised symptom provocation procedure immediately before stimulation. This standardised clinical procedure induces brief activation of obsession-related distress without engaging in compulsions. It is delivered by a trained clinician health-care professional and does not constitute psychotherapeutic treatment.",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Ghina Harika-Germaneau, Dr.","CONTACT","+33 5 16 52 61 18","ghina.harika-germaneau@ch-poitiers.fr",[39,58,72,87,100,116],{"facility":40,"status":26,"city":41,"state":26,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"CH Camille Claudel","Angoulême","16000","France","FR",{"type":46,"coordinates":47},"Point",[48,49],0.15345,45.64997,{"lat":49,"lon":48},[52,56],{"name":53,"role":35,"phone":54,"phoneExt":26,"email":55},"Rares IONASCU, Dr.","+33 5 45 67 56 56","Rares.ionascu@ch-claudel.fr",{"name":53,"role":57,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"facility":59,"status":26,"city":60,"state":26,"zip":26,"country":43,"countryCode":44,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"CH Esquirol","Limoges",{"type":46,"coordinates":62},[63,64],1.24759,45.83362,{"lat":64,"lon":63},[67,71],{"name":68,"role":35,"phone":69,"phoneExt":26,"email":70},"Philippe NUBUKPO, Pr.","+33 5 55 43 10 10","Philippe.nubukpo@9online.fr",{"name":68,"role":57,"phone":26,"phoneExt":26,"email":26},{"facility":73,"status":26,"city":74,"state":26,"zip":75,"country":43,"countryCode":44,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"CHU de Nantes","Nantes","44000",{"type":46,"coordinates":77},[78,79],-1.55336,47.21725,{"lat":79,"lon":78},[82,86],{"name":83,"role":35,"phone":84,"phoneExt":26,"email":85},"Anne SAUVAGET, Pr.","+33 2 98 71 63 26","Anne.sauvaget@chu-nantes.fr",{"name":83,"role":57,"phone":26,"phoneExt":26,"email":26},{"facility":88,"status":26,"city":89,"state":26,"zip":90,"country":43,"countryCode":44,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Unité de Recherche Clinique, Centre Hospitalier Henri Laborit","Poitiers","86000",{"type":46,"coordinates":92},[93,94],0.34348,46.58261,{"lat":94,"lon":93},[97,99],{"name":98,"role":35,"phone":36,"phoneExt":26,"email":37},"Ghina HARIKA-GERMANEAU, Dr.",{"name":98,"role":57,"phone":26,"phoneExt":26,"email":26},{"facility":101,"status":26,"city":102,"state":26,"zip":103,"country":43,"countryCode":44,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"CH Guillaume Régnier","Rennes","35000",{"type":46,"coordinates":105},[106,107],-1.67431,48.11109,{"lat":107,"lon":106},[110,114],{"name":111,"role":35,"phone":112,"phoneExt":26,"email":113},"Dominique DRAPIER, Pr.","+33 2 99 33 39 00","d.drapier@ch-guillaumeregnier.fr",{"name":115,"role":57,"phone":26,"phoneExt":26,"email":26},"Dominique DRAPIER",{"facility":117,"status":26,"city":118,"state":26,"zip":119,"country":43,"countryCode":44,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"CHNDS","Thouars","79100",{"type":46,"coordinates":121},[122,123],-0.21175,46.9815,{"lat":123,"lon":122},[126,130],{"name":127,"role":35,"phone":128,"phoneExt":26,"email":129},"Issa Wassouf, Dr.","+33 5 49 68 49 68","iwassouf@wanadoo.fr",{"name":131,"role":57,"phone":26,"phoneExt":26,"email":26},"Issa WASSOUF, Dr.",{"type":133,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100625966","tdcs-and-symptom-provocation-in-treatment-resistant-ocd-100625966",false,"NCT07429500","tDCS and Symptom Provocation in Treatment-Resistant OCD","Transcranial Direct Current Stimulation Associated With Symptom Provocation in the Management of Patients With Treatment-Resistant Obsessive-Compulsive Disorder.","PPS-TDCSTOC","Inclusion Criteria:\n\n* Diagnosis of Obsessive-Compulsive Disorder (OCD) according to DSM-5, with a duration ≥ 2 years.\n* Good insight, defined as a BABS score ≤ 18.\n* Chronic OCD, with either a Y-BOCS total score \\> 20 or a subscale score \\> 15.\n* Treatment-resistant OCD, defined as:\n\n  * failure of ≥ two adequate trials of SSRIs, or\n  * failure of one SSRI plus augmentation with an atypical antipsychotic,\n* and\u002For insufficient response after ≥ one year of cognitive-behavioural therapy.\n* Stable pharmacological treatment (fixed antidepressant dose) for at least 12 weeks prior to inclusion, with no significant improvement during this period.\n* Age 18 to 70 years.\n* Ability to provide informed written consent.\n* Affiliation with the French social security system.\n\nExclusion Criteria:\n\n* Women of childbearing potential without effective contraception, or those unwilling to maintain abstinence or contraception.\n* Pregnancy or breastfeeding.\n* Compulsory psychiatric hospitalisation.\n* Legal guardianship or curatorship.\n* Current DSM-5 Axis I disorder other than OCD (schizophrenia spectrum, bipolar disorder, substance use).\n* Current major depressive episode (MADRS \\> 21).\n* Suicide risk (MADRS item 10 \\> 3).\n* Dermatological lesions at electrode placement sites.\n* History of traumatic brain injury.\n* Presence of intracranial metal, pacemaker, or epilepsy.\n* Emergency situations or inability to provide informed consent.","ALL","18 Years","70 Years",{"count":146,"type":147},178,"ESTIMATED","INTERVENTIONAL",[150],"NA","The goal of this clinical trial is to learn if symptom provocation before transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD) patients. The main question it aims to answer is:\n\nCan symptom-provocation before tDCS improve therapeutic response in OCD patients ?\n\nResearchers will compare the clinical outcomes of OCD patients having received, in one arm, tDCS and, in the other arm, patients having received tDCS preceded by symptom provocation to see if therapeutic response and various other clinical variables differ.",[153],"Obsessive - Compulsive Disorder",[9],"NOT_YET_RECRUITING","2026-02-17",{"date":158,"type":159},"2026-02-24","ACTUAL",{"date":161,"type":147},"2026-04-01",{"date":163,"type":147},"2029-10-15",{"name":5,"class":6},6]