[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641092":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":11,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":11,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":11,"enrollmentInfo":58,"targetDuration":11,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":11,"overallStatus":67,"whyStopped":11,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"tDCS in older adults with LLD","EXPERIMENTAL",null,[13],"Device: High-intensity (6 mA) transcranial direct current stimulation (tDCS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","High-intensity (6 mA) transcranial direct current stimulation (tDCS)","High-intensity (6 mA), spaced (three daily sessions, 3 times a week, for 3 weeks) transcranial direct current stimulation (tDCS) in older adults (60 y\u002Fo and over) with Late-Life Depression",[9],[21],{"name":22,"affiliation":5,"role":23},"Andre Russowsky Brunoni, MD PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"Clinical Research Coordinator","CONTACT","214-645-2991","alexus.washington@utsouthwestern.edu",[31],{"facility":5,"status":11,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Dallas","Texas","75390","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-96.80667,32.78306,{"lat":41,"lon":40},[44],{"name":22,"role":23,"phone":11,"phoneExt":11,"email":11},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Andre Russowsky Brunoni","Professor and Chief of the Division of Interventional Psychiatry Department of Psychiatry UT Southwestern Medical Center Peter O'Donnell Jr. Brain Institute","100641092","tdcs-for-late-life-depression-100641092",false,"NCT07657234","tDCS for Late-Life Depression","High-Dose Spaced Bilateral tDCS for Late-Life Depression: Open-Label Pilot Study","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n1. age 60 years or older;\n2. diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Mini International Neuropsychiatric Interview (MINI);\n3. score of 17 or higher on the 17-item Hamilton Depression Rating Scale (HDRS-17) at screening;\n4. stable antidepressant regimen for at least four weeks prior to enrollment, if applicable;\n5. capacity to provide informed consent;\n6. Clinical Dementia Rating scale of 0 or 0.5.\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria will be excluded:\n\n1. contraindications to tDCS including metallic cranial implants, skin conditions at electrode sites (eczema, open wounds, burns, lesions), or history of adverse reaction to tDCS;\n2. contraindications to magnetic resonance imaging (MRI) including pacemaker, cochlear implants, ferromagnetic implants, or claustrophobia;\n3. history of seizures or epilepsy;\n4. bipolar disorder, psychotic disorders, or severe personality disorder;\n5. dementia or MoCA score below 17;\n6. substance use disorder within the past six months;\n7. neuromodulation treatment including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), tDCS, or vagus nerve stimulation (VNS) within the past six months;\n8. active suicidal ideation with plan or intent requiring a higher level of care;\n9. concurrent use of medications that substantially lower seizure threshold;\n10. pregnancy.","ALL","60 Years",{"count":59,"type":60},20,"ESTIMATED","INTERVENTIONAL",[63],"NA","The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).\n\nThe study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered as three daily sessions, 3 times a week, for 3 weeks in older adults (60 y\u002Fo and older) with late-life depression.",[66],"Late Life Depression (LLD)","NOT_YET_RECRUITING","2026-06-12",{"date":70,"type":71},"2026-06-18","ACTUAL",{"date":73,"type":60},"2026-08",{"date":75,"type":60},"2027-09",{"name":47,"class":6},1]