[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549319":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":36,"locations":46,"responsibleParty":65,"collaborators":67,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":25,"eligibilityCriteria":76,"healthyVolunteers":73,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Butler Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"active tDCS","ACTIVE_COMPARATOR","Each participant will undergo 5 consecutive (i.e., business days) sessions of active tDCS delivered to the DLPFC. During each session, participants are engaging in tasks that activate the cognitive control network.",[13],"Device: active tDCS",{"label":15,"type":16,"description":17,"interventionNames":18},"sham tDCS","SHAM_COMPARATOR","Each participant will undergo 5 consecutive (i.e., business days) sessions of sham tDCS delivered to the DLPFC. During each session, participants are engaging in tasks that activate the cognitive control network.",[19],"Device: sham tDCS",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","The anode will be placed over the right DLPFC (F4 on the EEG 10-20 system) and the cathode over the left DLPFC65 (F3) using 25cm2 sponges at an intensity of 2mA. Stimulation will be delivered for 20 minutes via two saline-soaked surface sponge electrodes and a battery-driven, constant current stimulator (NeuroConn DC Stimulator Plus).",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Same device and procedures as active tDCS with the exception that the device includes a study mode, in which subject-specific codes are entered to deliver active or sham stimulation, keeping the administrator blinded. Sham stimulation will use a method in which stimulation will be ramped up and back down over a 30-second period at the beginning and end of sham tDCS.",[15],[30,33],{"name":31,"affiliation":5,"role":32},"Abrantes Abrantes, Ph.D.","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":35,"role":32},"Michael Stein, M.D.","Boston University",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},"Ana M Abrantes, Ph.D.","CONTACT","4014556440","ana_abrantes@brown.edu",{"name":43,"role":39,"phone":44,"phoneExt":25,"email":45},"Julie A Desaulniers, M.S.","4014556219","jdesaulniers@butler.org",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Providence","Rhode Island","02906","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-71.41283,41.82399,{"lat":58,"lon":57},[61,62,64],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},{"name":63,"role":32,"phone":25,"phoneExt":25,"email":25},"Ana M. Abrantes, Ph.D.",{"name":34,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":66,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[68],{"name":69,"class":70},"National Institute on Drug Abuse (NIDA)","NIH","100549319","tdcs-to-decrease-opioid-relapse-uh3-100549319",false,"NCT06432465","tDCS to Decrease Opioid Relapse (UH3)","Inclusion Criteria:\n\n1. current opioid dependence\n2. between 21-60 years of age\n3. recent initiation of buprenorphine or methadone (≤90 days)\n4. enrolled in Butler Hospital's Alcohol and Drug Inpatient Unit, Alcohol and Drug Partial Hospital Treatment Program, Intensive Outpatient Services, or Outpatient Services at Butler Hospital OR receive opioid-treatment services in the community.\n\nExclusion Criteria:\n\n1. current diagnosis of organic brain disorder (e.g., Parkinson's disease, Huntington's disease, multiple sclerosis, intracranial mass\u002Finfection, hydrocephalus)\n2. bipolar, schizophrenia, schizoaffective, or schizophreniform disorder, or current psychosis associated with any disorder\n3. current suicidality\n4. evidence of significant neurocognitive dysfunction\n5. conditions associated with heightened tDCS risks, e.g., seizure disorder, nonremovable intracranial metal objects (other than dental fillings and dental implants), skin disease or active lesions on the scalp, migraine\u002Fother headache disorder with significant active symptoms, traumatic brain injury or skull fracture within the past year, any implanted medical devices or device components that can interact with electromagnetic fields or are controlled by physiological signals\n6. probation\u002Fparole requirements or an upcoming move that might interfere with protocol participation\n7. planning to terminate buprenorphine or methadone in less than 3 months\n8. current pregnancy or plan to become pregnant in the next month.","ALL","21 Years","60 Years",{"count":81,"type":82},100,"ESTIMATED","INTERVENTIONAL",[85],"NA","Investigators will measure behavioral and brain responses following transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) (anode on right DLPFC, cathode on the left DLPFC) delivered during cognitive control network (CCN) priming. In Phase I, the EEG provided validation of expected changes in these networks following tDCS stimulation of the DLPFC. In this current phase (II), the investigators will perform a larger randomized clinical trial (RCT) (active vs. sham control) to address long-term neurobehavioral outcomes, including opioid relapse, craving, and sustained EEG changes.",[88],"Opioid Use Disorder",[90,91,92,93,94],"opioid craving","buprenorphine","methadone","EEG","transcranial direct current stimulation","2026-06-26",{"date":97,"type":98},"2026-06-29","ACTUAL",{"date":100,"type":98},"2024-04-17",{"date":102,"type":82},"2026-12-31",{"name":5,"class":6},1]