[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100454273":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":64,"collaborators":66,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":40,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":40,"overallStatus":45,"whyStopped":40,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"A-tDCS","EXPERIMENTAL","Participants randomized to tDCS will undergo 15- 30 minute sessions over 5 weeks of A-tDCS to the ipsilesional frontoparietal cortex while participating in computerized cognitive therapy (CCT).",[13],"Device: Anodal transcranial Direct Current Stimulation (A-tDCS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Intervention","ACTIVE_COMPARATOR","Participants randomized to sham will undergo 15- 30 minute sessions over 5 weeks of a sham-intervention, also applied to the ipsilesional frontoparietal cortex, while participating in computerized cognitive therapy (CCT).",[19],"Device: Sham Intervention",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Anodal transcranial Direct Current Stimulation (A-tDCS)","Participants randomized to tDCS will undergo 5 weeks of A-tDCS + CCT.",[9],[27],"Computerized Cognitive Therapy (CCT)",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Participants randomized to sham-intervention will undergo 5 weeks of sham + CCT.",[15],[27],[33],{"name":34,"affiliation":5,"role":35},"Elisabeth B Marsh, MD","PRINCIPAL_INVESTIGATOR",[37],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","410-550-8703",null,"ebmarsh@jhmi.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Johns Hopkins Bayview Medical Center","RECRUITING","Baltimore","Maryland","21224","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-76.61219,39.29038,{"lat":55,"lon":54},[58,60],{"name":59,"role":38,"phone":39,"phoneExt":40,"email":41},"Eliabeth B Marsh, MD",{"name":61,"role":38,"phone":62,"phoneExt":40,"email":63},"Rafael H Llinas, MD","4105501042","rllinas@jhmi.edu",{"type":65,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR",[67,69],{"name":68,"class":6},"University of Maryland, College Park",{"name":70,"class":71},"National Institutes of Health (NIH)","NIH","100454273","tdcs-to-improve-post-stroke-cognitive-impairment-100454273",false,"NCT05195398","TDCS to Improve Post-Stroke Cognitive Impairment","TIPSCI","Inclusion Criteria:\n\n1. Adults (≥18 years) presenting with neurological symptoms due to acute ischemic stroke (symptom onset within the week prior to admission).\n2. Evidence on brain MRI of acute ischemic stroke (imaging negative strokes and TIAs will be excluded).\n3. Native English speaker (by self-report) prior to stroke.\n4. NIHSS \\\u003C8 at initial follow-up visit (approximately 30 days post-stroke).\n5. mRS 0-2 at initial follow-up visit.\n\nExclusion Criteria:\n\n1. Primary intracerebral hemorrhage- as evidenced by blood on head CT or MRI.\n2. Presence of proximal large vessel occlusion.\n3. Cortical exam findings including aphasia or neglect.\n4. Prior report or history of dementia or undertreated psychiatric illness.\n5. Uncorrected hearing or visual loss.\n6. Inability to attend treatment or follow-up sessions.\n7. Inability to travel to College Park (UMD) for MEG recording sessions.\n8. Presence of any of the following that would lead to significant artifact on MEG: cardiac pacemaker, intracranial clips, metal implants or external clips within 10mm of the head, metal implants in the eyes (unlikely given that all patients will have an MRI and criteria are similar).\n9. Claustrophobia, obesity, and\u002For any other reason leading to difficulty staying in the MEG machine for up to 1 hour.","ALL","18 Years","100 Years",{"count":83,"type":84},60,"ESTIMATED","INTERVENTIONAL",[87],"NA","The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDCS + computerized cognitive treatment (CCT) versus sham + CCT (approximately 30 patients in each arm). Clinical evaluation including assessment of cognition will be performed pre- and post-intervention by individuals on the study team blinded to the participant's intervention. Participants will also undergo functional neuroimaging with magnetoencephalography (MEG) pre- and post-intervention (1, 3, and 6 months post-stroke to evaluate for initial and longer-term effects of treatment on cerebral activation patterns and functional connectivity). Neuroimaging and clinical outcomes will be assessed to determine the effect of tDCS versus sham + CCT on psMCI.",[90,91,92],"Stroke","Stroke Sequelae","Cognitive Impairment","2025-09-10",{"date":95,"type":96},"2025-09-16","ACTUAL",{"date":98,"type":96},"2022-09-01",{"date":100,"type":84},"2027-08-31",{"name":5,"class":6},1]