[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513675":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":44,"locations":54,"responsibleParty":72,"collaborators":74,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":31,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":31,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":31,"overallStatus":56,"whyStopped":31,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Icahn School of Medicine at Mount Sinai","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Group and Family-Based Cognitive Behavioral Therapy (GF-CBT-TH)","EXPERIMENTAL","GF-CBT via telehealth is an intervention consisting of three parts: 15 group sessions for young people, 15 individual sessions for young people, and 15 group sessions for families. The group sessions for young people and families focus on teaching CBT skills. The goal is to enhance reasoning, decision-making, and positive beliefs while reducing cognitive biases, distress, and isolation. The individual sessions personalize the CBT skills learned in the group, focusing on tailoring skills to personal goals. Family members also participate in group sessions to learn the same CBT skills and how to prompt and support their young family members in using these skills. All sessions are conducted via Telehealth",[13,14,15],"Behavioral: CBT Skills Group for CHR Youth","Behavioral: Individual CBT sessions","Behavioral: CBT Skills Group for Families",{"label":17,"type":10,"description":18,"interventionNames":19},"Family-Based Cognitive Behavioral Therapy (F-CBT-TH)","F-CBT via telehealth consists of two parts: 15 family sessions and 15 individual sessions for young people. The family sessions focus on teaching CBT skills to a family units. The individual sessions with youth personalize the CBT skills learned in the family sessions, focusing on tailoring skills to personal goals. All sessions are conducted via Telehealth.",[14,15],{"label":21,"type":22,"description":23,"interventionNames":24},"Individual Cognitive Behavioral Therapy (I-CBT-TH)","ACTIVE_COMPARATOR","I-CBT-TH via telehealth consists of two components: 15 CBT Skill Learning sessions and 15 follow-up session that personalizes the learned skills. All sessions are conducted via Telehealth.",[14],[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"BEHAVIORAL","CBT Skills Group for CHR Youth","CBT skills group is designed to boost peer support, reduce isolation, normalize psychotic-like experiences to lessen distress, reduce cognitive biases, facilitate positive beliefs, and enhance reasoning and decision-making. CBT skills group uses \"CBT to Prevent Paranoia\" manual to teach individuals to make adaptive appraisals of their experiences (e.g. voices and other cognitive intrusions) to prevent the perception of such events as threatening.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Individual CBT sessions","CBT skills learned in group are personalized in individual sessions focused on: a) facilitating learning of CBT skills; b) tailoring CBT skills to personal goals; c) facilitating successful interaction with peers in the group; and d) providing academic and vocational support. Youth may opt to invite family members to join individual sessions as needed.",[17,9,21],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"CBT Skills Group for Families","Family members are taught the same CBT skills that are taught to CHR youth to facilitate use of CBT skills at home. Family members also learn how to prompt CHR youth to use CBT skills through effective communication, such as empathic listening and encouraging alternative explanations. CBT skills group for family members uses a combination of didactic learning (skills are described in \"CBT Skills for Families\" manual and demonstrated via video examples) and practice (skills are role-played). Youth attend one group session and one individual session per week, and family members attend one group session per week.",[17,9],[41],{"name":42,"affiliation":5,"role":43},"Yulia Landa","PRINCIPAL_INVESTIGATOR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":31,"email":49},"Yulia Landa, PsyD, MS","CONTACT","212-585-4658","yulia.landa@mssm.edu",{"name":51,"role":47,"phone":52,"phoneExt":31,"email":53},"Rachel Jespersen, LMSW","212-585-4641","rachel.jespersen@mssm.edu",[55],{"facility":5,"status":56,"city":57,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","New York","10029","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-74.00597,40.71427,{"lat":65,"lon":64},[68,70,71],{"name":69,"role":47,"phone":48,"phoneExt":31,"email":49},"Yulia Landa, PsyD,MS",{"name":51,"role":47,"phone":52,"phoneExt":31,"email":53},{"name":42,"role":43,"phone":31,"phoneExt":31,"email":31},{"type":43,"investigatorFullName":42,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Assistant Professor of Psychiatry",[75],{"name":76,"class":77},"National Institute of Mental Health (NIMH)","NIH","100513675","telehealth-cognitive-behavioral-therapy-for-youth-at-risk-for-psychosis-100513675",false,"NCT05968560","Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis","Telehealth Adaptation of Group and Family-Based Cognitive Behavioral Therapy for Youth at Risk for Psychosis","Inclusion criteria:\n\n* Age 14-25\n* Ability to participate in assessments and treatment in English\n* Meets criteria for psychosis-risk on SIPS\n* Stable on medications; no changes within 1 month prior to enrollment\n* Identification of one \"family member\" with \\>4 hours\u002Fweek contact who is willing to participate (\"Family member\" can be any blood relative, spouse, significant other, or close friend whom the subject identifies as a consistent and important person in their life).\n\nExclusion criteria:\n\n* Intellectual disability (IQ\\\u003C70)\n* Medical condition known to cause psychosis\n* Moderate or severe substance use disorder and active use within the past 30 days.","ALL","14 Years","25 Years",{"count":89,"type":90},72,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR). Psychosis typically emerges during late adolescence or early adulthood, significantly impacting long-term functioning. While CHR programs have the potential to reduce illness severity, individuals often face barriers such as stigma and limited access to services. Telehealth interventions could address these barriers and improve treatment accessibility and engagement. The study will focus on Group and Family-Based Cognitive Behavioral Therapy, Family-Based CBT, and individual CBT, adapted for telehealth delivery (GF-CBT-TH, F-CBT-TH, and I-CBT-TH). Participants aged 14-25 who meet CHR criteria will be randomly assigned to one of these interventions. Feasibility will be measured by recruitment rate, attendance, and retention. The study will assess the impact of the interventions on cognitive biases, social connectedness, family emotional climate, and proficiency in CBT skills. The three intervention groups will be compared in terms of psychosocial functioning, symptom severity, rates of remission from CHR, and rates of transition to psychosis. Additionally, factors like patient treatment preference, family emotional climate, and sociodemographic factors will be explored as potential moderators of treatment outcomes. Qualitative interviews will be conducted with participants and clinicians to inform dissemination efforts.",[96],"Clinical High Risk for Psychosis (CHR)","2026-01-16",{"date":99,"type":100},"2026-01-20","ACTUAL",{"date":102,"type":100},"2023-07-21",{"date":104,"type":90},"2026-12-31",{"name":5,"class":6},1]