[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632772":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":32,"locations":38,"responsibleParty":54,"collaborators":31,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":31,"enrollmentInfo":68,"targetDuration":31,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":40,"whyStopped":31,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Azienda Unita Sanitaria Locale di Piacenza","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Telemedicine-guided management","EXPERIMENTAL","Patients randomized to this arm will undergo an early structured telemedicine consultation after hospital discharge, supported by remote monitoring of clinical parameters including blood pressure, heart rate, oxygen saturation, body weight, and single-lead electrocardiogram. Follow-up is designed to enable early reassessment and facilitate timely initiation and up-titration of guideline-directed medical therapy (GDMT) according to current recommendations.",[13],"Other: Telemedicine-based follow-up",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","ACTIVE_COMPARATOR","Patients randomized to this arm will receive standard post-discharge management according to local clinical practice, including in-person follow-up visits and GDMT optimization at the discretion of the treating physician.",[19],"Other: Standard follow-up",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Telemedicine-based follow-up","Structured telemedicine follow-up including early post-discharge consultation and remote multiparametric monitoring (blood pressure, heart rate, oxygen saturation, body weight, and single-lead electrocardiogram). Clinical data are reviewed by a dedicated healthcare team to enable early reassessment and timely optimization of guideline-directed medical therapy.",[9],[26],"TELEHEART intervention",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Standard follow-up","Usual care consisting of standard in-person clinical follow-up visits and treatment optimization according to routine clinical practice.",[15],null,[33],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Clinical Research Office, AUSL Piacenza","CONTACT","+ 39 0523 302208","ricerca@ausl.pc.it",[39],{"facility":34,"status":40,"city":41,"state":31,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Piacenza","29121","Italy","IT",{"type":46,"coordinates":47},"Point",[48,49],9.69342,45.05242,{"lat":49,"lon":48},[52],{"name":53,"role":35,"phone":36,"phoneExt":31,"email":37},"Ufficio ricerca AUSL Piacenza",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Andrea Tedeschi","Doctor","100632772","telemedicine-guided-uptitration-of-therapy-in-chronic-heart-failure-100632772",false,"NCT07518030","Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure","TELEHEART Trial: Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure","TELEHEART","Inclusion criteria: Participants must meet all of the following criteria:\n\n1. Provision of written informed consent.\n2. Age ≥18 years.\n3. Recent diagnosis of HFrEF, defined according to ESC criteria, established in either an inpatient or outpatient setting.\n4. No prior initiation of GDMT for HF at the time of enrollment, or treatment limited to a single agent with potential disease-modifying effects prescribed for a different clinical indication.\n5. Availability of adequate digital literacy, either by the patient or a caregiver, defined as the ability to use electronic devices for remote communication (phone\u002Fvideo calls), transmission of vital parameters (body weight, blood pressure, heart rate), and interaction with digital health tools. In cases of insufficient patient digital skills, the presence of a caregiver with adequate digital competence is acceptable.\n6. Any etiology of HF is eligible, including ischemic, valvular, primary or infiltrative cardiomyopathies, iatrogenic or toxic causes, and tachycardia-induced cardiomyopathy.\n\nExclusion Criteria:\n\n* Ongoing treatment with two or more guideline-directed heart failure medications at the time of HFrEF diagnosis\n* Presence of severe comorbidities or clinical instability requiring prolonged or continuous hospital management\n* Estimated life expectancy \\\u003C12 months\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","This is a single-center, randomized, open-label, no-profit interventional trial designed to evaluate the effectiveness of a telemedicine-based follow-up strategy compared with standard ambulatory care in patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF). The study aims to determine whether telemedicine-guided management improves the optimization of guideline-directed medical therapy (GDMT), measured as change in GDMT score at 6 months. Patients will be randomized to either a telemedicine group, involving remote multiparametric monitoring and structured teleconsultations, or a standard-of-care group based on conventional in-person follow-up. Secondary objectives include the assessment of safety, treatment adherence, quality of life, and heart failure-related urgent visits, emergency department access, and hospitalizations. This study will provide evidence on the role of telemedicine in facilitating early and effective optimization of heart failure therapy and improving clinical management in a real-world setting.",[76],"Heart Failure With Reduced Ejection Fraction (HFrEF)",[78,79,80,81],"Heart failure with reduced ejection fraction","Telemedicine","Guidelines direct medical therapy","Uptitration","2026-05-15",{"date":84,"type":85},"2026-05-18","ACTUAL",{"date":87,"type":85},"2026-03-20",{"date":89,"type":70},"2028-06-01",{"name":5,"class":6},1]