[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100414869":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":66,"collaborators":69,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of South Carolina","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Aphasia Remote Therapy (ART)","EXPERIMENTAL","All participants in this group will receive 3 weeks of daily semantically-focused treatment (semantic feature analysis, semantic barrier task and verb network strengthening therapy) and 3 weeks of daily phonologically-focused treatment (phonological components analysis, phonological production task, phonological judgment task). Participants will be randomized to order of treatment.\n\nAll treatment will be done remotely with a speech-language pathologist through an online platform using therapy applications. Participants will be provided with teletherapy kits (including an Internet hotspot if needed) to complete the therapy tasks.",[13,14],"Behavioral: Semantically-focused therapy tasks","Behavioral: Phonologically-focused therapy tasks",{"label":16,"type":17,"description":18,"interventionNames":19},"In-Clinic Therapy (I-CT)","ACTIVE_COMPARATOR","All participants in this group will receive 3 weeks of daily semantically-focused treatment (semantic feature analysis, semantic barrier task and verb network strengthening therapy) and 3 weeks of daily phonologically-focused treatment (phonological components analysis, phonological production task, phonological judgment task). Participants will be randomized to order of treatment.\n\nAll treatment will be done in person with a speech-language pathologist at the UofSC Aphasia Lab.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Semantically-focused therapy tasks","1\\) Semantic feature analysis (SFA; Boyle \\& Coelho, 1995; Boyle, 2004). For each pictured stimulus the participant is prompted to name the picture. Then, s\u002Fhe is encouraged to produce semantically related words that represent features similar to the target word. 2) Semantic barrier task. This approach includes features of the Promoting Aphasics' Communication Effectiveness (PACE; Davis \\& Wilcox,1985). The goal of the task is for one participant (e.g., person with aphasia) to describe each card so that the other participant (e.g., clinician) can guess the picture on the card. 3) Verb network strengthening therapy (VNeST; Edmonds et al., 2009; 2014) targets lexical retrieval of verbs and their thematic nouns. The objective of VNeST is for the participant to generate verb-noun associates with the purpose of strengthening the connections between the verb and its thematic roles.",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Phonologically-focused therapy tasks","1\\) Phonological components analysis task (PCA; Leonard et al., 2008). The participant first attempts to name a given picture and then to identify the phonological features of the target words. 2) Phonological production task focuses on the identification of phonological features of targeted, imageable nouns and verbs. It requires the participant to sort picture stimuli based on the number of syllables and then to identify a hierarchy of phonological features. Once each targeted feature is identified for the pair of words, the participant is required to blend the syllables\u002Fsounds together. 3) Phonological judgment task relies on computerized presentation of verbs and nouns where participants are required to judge whether pairs of words include similar phonological features (e.g. # of syllables, initial phonemes, final phonemes, rhyming).",[9,16],[32],{"name":33,"affiliation":5,"role":34},"Julius Fridriksson, Ph.D.","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Sara Sayers, M.S.","CONTACT","803-777-2693","ssayers@mailbox.sc.edu",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Kelli Powell, B.S.","803-777-5051","KELLIAP@mailbox.sc.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University of South Carolina Aphasia Lab","RECRUITING","Columbia","South Carolina","29201","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-81.03481,34.00071,{"lat":58,"lon":57},[61,62,64],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":42,"role":38,"phone":43,"phoneExt":26,"email":63},"kelliap@mailbox.sc.edu",{"name":65,"role":34,"phone":26,"phoneExt":26,"email":26},"Julius Fridriksson, Ph.D",{"type":34,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Julius Fridriksson","Primary Investigator",[70,73],{"name":71,"class":72},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH",{"name":74,"class":6},"Medical University of South Carolina","100414869","telerehabilitation-for-aphasia-terra-100414869",false,"NCT04682223","Telerehabilitation for Aphasia (TERRA)","Center for the Study of Aphasia Recovery (C-STAR): Telerehabilitation for Aphasia (TERRA)","TERRA","Inclusion Criteria:\n\n1. Participants must have sustained a left hemisphere ischemic or hemorrhagic stroke at least 12 months prior to enrollment.\n2. Participants must primarily speak English for at least the past 20 years.\n3. Participants must be capable of giving informed consent or indicating another to provide informed consent.\n4. Participants must be between 21-80 years of age.\n5. Participants must be magnetic resonance imaging (MRI) compatible (e.g., no metal implants, not claustrophobic) on a 3-Tesla (3T) scanner.\n\nExclusion Criteria:\n\n1. Participants must not have previous neurological disease affecting the brain (e.g. history of traumatic brain injury).\n2. Participants must not have severely limited speech production (severe unintelligibility) and\u002For auditory comprehension that interferes with adequate participation in the therapy provided (i.e., WAB-R Spontaneous Speech rating scale score of 0-1 or WAB-R Comprehension score of 0-1).\n3. Participants must not have a history of stroke to the right hemisphere of the brain.\n4. Participants must not have a bilateral, cerebellar or brainstem stroke.\n5. Participants must not have anything that makes them be 3T MRI incompatible\n6. Insufficient intelligible speech to provide accurate responses with discourse\u002Fnaming.","ALL","21 Years","80 Years",{"count":87,"type":88},100,"ESTIMATED","INTERVENTIONAL",[91],"NA","Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) to the more traditional In-Clinic Therapy (I-CT).",[94,95,96],"Aphasia","Stroke","Stroke Rehabilitation",[98,99,100,101],"aphasia","stroke","telerehabilitation","speech-language therapy","2026-04-01",{"date":104,"type":105},"2026-04-02","ACTUAL",{"date":107,"type":105},"2021-05-05",{"date":109,"type":88},"2027-03",{"name":5,"class":6},1]