[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470467":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":47,"centralContacts":51,"locations":56,"responsibleParty":76,"collaborators":78,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":10,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":10,"enrollmentInfo":91,"targetDuration":10,"studyType":94,"phases":10,"briefSummary":95,"conditions":96,"keywords":10,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"M.D. Anderson Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Observational (RT, biopsy)",null,"Patients undergo RT on day 1. Patients also undergo tumor punch biopsies and blood sample collection prior to the first fraction and on days 1, 3, and 7.",[13,14,15],"Procedure: Biopsy","Procedure: Biospecimen Collection","Radiation: Radiation Therapy",[17,25,32],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","Biopsy","Undergo tumor punch biopsy",[9],[23,24],"BIOPSY_TYPE","Bx",{"type":18,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Biospecimen Collection","Undergo blood sample collection",[9],[30,31],"Biological Sample Collection","Biospecimen Collected",{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"RADIATION","Radiation Therapy","Undergo RT",[9],[38,39,40,41,42,43,44,45,46],"Cancer Radiotherapy","Irradiate","Irradiated","Irradiation","Radiation","Radiotherapeutics","Radiotherapy","RT","Therapy, Radiation",[48],{"name":49,"affiliation":5,"role":50},"Simona F Shaitelman, MD","PRINCIPAL_INVESTIGATOR",[52],{"name":49,"role":53,"phone":54,"phoneExt":10,"email":55},"CONTACT","(713) 563-8491","sfshaitelman@mdanderson.org",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"M D Anderson Cancer Center","RECRUITING","Houston","Texas","77030","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-95.36327,29.76328,{"lat":69,"lon":68},[72,75],{"name":73,"role":53,"phone":74,"phoneExt":10,"email":55},"Simona F. Shaitelman, MD","713-563-8491",{"name":73,"role":50,"phone":10,"phoneExt":10,"email":10},{"type":77,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[79],{"name":80,"class":81},"Artidis","INDUSTRY","100470467","temporal-immunologic-changes-with-hypofractionated-radiation-induced-dna-damage-in-breast-cancer-100470467",false,"NCT05406232","Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer","Breast Radiation-induced Immunologic Genomic Hypofractionated Temporal Radiation Alterations DNA Damage (BRIGHT-RAD) Study.","Inclusion Criteria:\n\n* Patients \\>= 18 years of age with biopsy proven invasive breast cancer\n* Breast cancer that appears to be superficially accessible to a tumor punch biopsy\n* Patients thought to derive clinical benefit from palliative RT to the breast\u002Fchestwall\n* In discussions with the medical oncologist, if clinically reasonable, systemic therapy will be held during RT\n\nExclusion Criteria:\n\n* A history of prior radiation to the area requiring radiation for which the attending physician believes reirradiation could not be safely delivered\n* Pregnancy\n* Active usage of anticoagulant medications that are considered to pose an increased risk of tumor punch biopsies\n* Receipt of immunotherapy or chemotherapy 7 days prior to start of RT","ALL","18 Years",{"count":92,"type":93},36,"ESTIMATED","OBSERVATIONAL","This study assesses changes to the immune cells following hypofractionated radiation-induced DNA damage in breast cancer patients. Radiation therapy may cause immune cells to enter tumors and target cancer cells. The goal of this study is to measure the change in the level of immune cells in the tumor before and after radiation therapy.",[97,98],"Breast Carcinoma","Invasive Breast Carcinoma","2026-04-30",{"date":101,"type":102},"2026-05-06","ACTUAL",{"date":104,"type":102},"2023-09-15",{"date":106,"type":93},"2026-12-31",{"name":5,"class":6},1]