[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633361":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":26,"collaborators":11,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":34,"acronym":11,"eligibilityCriteria":35,"healthyVolunteers":32,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":11,"studyType":42,"phases":43,"briefSummary":45,"conditions":46,"keywords":11,"overallStatus":48,"whyStopped":11,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":11},{"fullName":5,"class":6},"Minia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Temporary Uterine Tourniquet Application","ACTIVE_COMPARATOR",null,[13],"Procedure: Temporary Uterine Tourniquet Application",{"label":15,"type":10,"description":11,"interventionNames":16},"Local Myometrial Epinephrine Injection",[17],"Procedure: Local Myometrial Epinephrine Injection",[19,23],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":11},"PROCEDURE","The tourniquet will be tightened just enough to achieve visible blanching of the uterus, indicating adequate vascular occlusion, but without excessive tension to avoid tissue damage",[9],{"type":20,"name":15,"description":24,"armGroupLabels":25,"otherNames":11},"Approximately 5-10 mL of the diluted epinephrine will be injected into the myometrium surrounding each fibroid, specifically at the base of the myoma and along the planned incision line, using a laparoscopic injection needle.",[15],{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Mohamed Hassan Mohamed Abdel Ghfar","Lecturer of Obstetrics and Gynecology","100633361","temporary-uterine-tourniquet-application-versus-local-myometrial-epinephrine-injection-during-laparoscopic-myomectomy-100633361",false,"NCT07525687","Temporary Uterine Tourniquet Application Versus Local Myometrial Epinephrine Injection During Laparoscopic Myomectomy","Inclusion Criteria:\n\n* Female patients aged 18-45 years.\n* Diagnosed with symptomatic uterine leiomyomas requiring laparoscopic myomectomy.\n* Presence of at least one myoma with a diameter ≥3 cm and ≤10 cm.\n* Patients with up to 3 myomas (to standardize surgical complexity).\n* Preoperative hemoglobin level ≥10 g\u002FdL.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Patients with more than 3 myomas or any myoma larger than 10 cm.\n* Patients with suspected uterine malignancy (e.g., leiomyosarcoma).\n* Patients with known bleeding disorders or on anticoagulant therapy that cannot be safely discontinued.\n* Patients with significant cardiovascular disease, uncontrolled hypertension, or arrhythmias (relative contraindications for epinephrine).\n* Patients with active pelvic infection.\n* Patients with previous extensive uterine surgery (e.g., multiple prior myomectomies or extensive uterine reconstruction) that may compromise uterine integrity.\n* Patients undergoing concurrent major gynecological procedures that might significantly affect blood loss (e.g., hysterectomy, extensive adhesiolysis).\n* Patients with known allergy to epinephrine.\n* Patients unwilling or unable to comply with follow-up protocols.","FEMALE","18 Years","45 Years",{"count":40,"type":41},37,"ESTIMATED","INTERVENTIONAL",[44],"NA","While both local vasoconstrictors and tourniquet application are recognized methods for blood loss control, there is a paucity of head-to-head randomized controlled trials directly comparing these two distinct approaches in laparoscopic myomectomy. Existing data often compare these methods to no intervention or to other less common techniques. A direct comparison is essential to determine which method offers superior hemostasis with an acceptable safety profile in the laparoscopic setting. This study aims to address this gap in the literature.",[47],"Laparoscopic Myomectomy","NOT_YET_RECRUITING","2026-04-06",{"date":51,"type":52},"2026-04-13","ACTUAL",{"date":54,"type":41},"2026-04-20",{"date":56,"type":41},"2027-01-20",{"name":5,"class":6}]