[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100383563":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":189,"collaborators":191,"id":201,"slug":202,"hasResults":203,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":203,"sex":209,"minAge":210,"maxAge":7,"enrollmentInfo":211,"targetDuration":214,"studyType":215,"phases":7,"briefSummary":216,"conditions":217,"keywords":7,"overallStatus":32,"whyStopped":7,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":228},{"fullName":5,"class":6},"University of Birmingham","OTHER",null,[9,12],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Matched Tumour and Blood Sample - Research Pathway","For patient's undergoing surgery fresh tissue will be collected from the initial surgery and frozen until shipment to the Oxford BRAIN MATRIX Lab. Matched blood sample for germline DNA will be taken post-Platform Study entry. For patients with progression with available tumour samples from previous tumour surgery, blood will be collected and sent to Oxford along with their tumour samples.\n\nSamples will be shipped together to Oxford for molecular analysis (Whole Genome Sequencing (WGS) and EPIC array). The BRAIN MATRIX neuropathology and genomics team will produce an integrated report (histology, WGS, Heidelberg Classifier) for each case in consultation with the local neuropathology team. Once data is available, a virtual MDT with the BRAIN MATRIX neuropathology, genomics team and local site will be held to ensure all relevant information is incorporated in the final BRAIN MATRIX diagnostic report. The resulting integrated histological-molecular report will be available to local sites",{"type":6,"name":13,"description":14,"armGroupLabels":7,"otherNames":7},"Matched Tumour and Blood Sample - NHS GMS pathway","Tessa Jowell BRAIN MATRIX centres in England can submit matched tissue and blood samples for Whole Genome Sequencing through the standard of care NHS Genomic Medicine Service pathway via their Genomic Laboratory Hub. For those from Devolved Nations, samples must go to the Oxford BRAIN MATRIX Laboratory who can facilitate the processing of samples through an alternative NHS GMS GLH or via the research pathway.",[16],{"name":17,"affiliation":18,"role":19},"Colin Watts","Unviersity of Birmingham","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":7,"email":25},"Rhys Mant","CONTACT","0121 414 6788","brainmatrix@trials.bham.ac.uk",{"name":27,"role":23,"phone":7,"phoneExt":7,"email":28},"Joshua Savage","j.savage.1@bham.ac.uk",[30,46,56,68,78,87,99,111,123,132,144,153,165,177],{"facility":31,"status":32,"city":33,"state":7,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust","RECRUITING","Birmingham","B15 2TH","United Kingdom","UK",{"type":38,"coordinates":39},"Point",[40,41],-1.89983,52.48142,{"lat":41,"lon":40},[44],{"name":45,"role":19,"phone":7,"phoneExt":7,"email":7},"Victoria Wykes",{"facility":47,"status":48,"city":49,"state":7,"zip":50,"country":35,"countryCode":36,"cosmosGeoPoint":51,"geoPoint":55,"contacts":7},"Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust","TERMINATED","Cambridge","CB2 0QQ",{"type":38,"coordinates":52},[53,54],0.11667,52.2,{"lat":54,"lon":53},{"facility":57,"status":32,"city":58,"state":7,"zip":59,"country":35,"countryCode":36,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Velindre Cancer Centre, Velindre University NHS Trust","Cardiff","CF14 2TL",{"type":38,"coordinates":61},[62,63],-3.18,51.48,{"lat":63,"lon":62},[66],{"name":67,"role":19,"phone":7,"phoneExt":7,"email":7},"Jillian Maclean",{"facility":69,"status":70,"city":71,"state":7,"zip":72,"country":35,"countryCode":36,"cosmosGeoPoint":73,"geoPoint":77,"contacts":7},"NHS Lothian","ACTIVE_NOT_RECRUITING","Edinburgh","EH4 2XU",{"type":38,"coordinates":74},[75,76],-3.19648,55.95206,{"lat":76,"lon":75},{"facility":79,"status":70,"city":80,"state":7,"zip":81,"country":35,"countryCode":36,"cosmosGeoPoint":82,"geoPoint":86,"contacts":7},"Queen Elizabeth Unviersity Hospital, NHS Greater Glasgow and Clyde Health Board","Glasgow","G51 4TF",{"type":38,"coordinates":83},[84,85],-4.25763,55.86515,{"lat":85,"lon":84},{"facility":88,"status":32,"city":89,"state":7,"zip":90,"country":35,"countryCode":36,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"St James's University Hospital, Leeds Teaching Hospitals NHS Trust","Leeds","LS9 7TF",{"type":38,"coordinates":92},[93,94],-1.54785,53.79648,{"lat":94,"lon":93},[97],{"name":98,"role":19,"phone":7,"phoneExt":7,"email":7},"Ryan Mathew",{"facility":100,"status":32,"city":101,"state":7,"zip":102,"country":35,"countryCode":36,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"The Walton Centre, The Walton Centre NHS Foundation Trust","Liverpool","L9 7LJ",{"type":38,"coordinates":104},[105,106],-2.97794,53.41058,{"lat":106,"lon":105},[109],{"name":110,"role":19,"phone":7,"phoneExt":7,"email":7},"Michael Jenkinson",{"facility":112,"status":32,"city":113,"state":7,"zip":114,"country":35,"countryCode":36,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"King's College Hospital, King's College Hospital NHS Foundation Trust","London","SE5 9RS",{"type":38,"coordinates":116},[117,118],-0.12574,51.50853,{"lat":118,"lon":117},[121],{"name":122,"role":19,"phone":7,"phoneExt":7,"email":7},"Keyoumars Ashkan",{"facility":124,"status":32,"city":113,"state":7,"zip":125,"country":35,"countryCode":36,"cosmosGeoPoint":126,"geoPoint":128,"contacts":129},"Charing Cross Hospital, Imperial College Healthcare NHS Trust","W6 8RF",{"type":38,"coordinates":127},[117,118],{"lat":118,"lon":117},[130],{"name":131,"role":19,"phone":7,"phoneExt":7,"email":7},"Matthew Williams",{"facility":133,"status":32,"city":134,"state":7,"zip":135,"country":35,"countryCode":36,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"The Christie Hospital, The Christie NHS Foundation Trust","Manchester","M20 4BX",{"type":38,"coordinates":137},[138,139],-2.23743,53.48095,{"lat":139,"lon":138},[142],{"name":143,"role":19,"phone":7,"phoneExt":7,"email":7},"Catherine McBain",{"facility":145,"status":32,"city":134,"state":7,"zip":146,"country":35,"countryCode":36,"cosmosGeoPoint":147,"geoPoint":149,"contacts":150},"Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust","M6 8HD",{"type":38,"coordinates":148},[138,139],{"lat":139,"lon":138},[151],{"name":152,"role":19,"phone":7,"phoneExt":7,"email":7},"David Coope",{"facility":154,"status":32,"city":155,"state":7,"zip":156,"country":35,"countryCode":36,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust","Newcastle upon Tyne","NE7 7DN",{"type":38,"coordinates":158},[159,160],-1.61396,54.97328,{"lat":160,"lon":159},[163],{"name":164,"role":19,"phone":7,"phoneExt":7,"email":7},"Joanne Lewis",{"facility":166,"status":32,"city":167,"state":7,"zip":168,"country":35,"countryCode":36,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Queen's Medical Centre, Nottingham University Hospitals NHS Trust","Nottingham","NG7 2UH",{"type":38,"coordinates":170},[171,172],-1.15047,52.9536,{"lat":172,"lon":171},[175],{"name":176,"role":19,"phone":7,"phoneExt":7,"email":7},"Stuart Smith",{"facility":178,"status":32,"city":179,"state":7,"zip":180,"country":35,"countryCode":36,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Churchill Hospital, Oxford University Hospitals NHS Foundation Trust","Oxford","OX3 9DU",{"type":38,"coordinates":182},[183,184],-1.25596,51.75222,{"lat":184,"lon":183},[187],{"name":188,"role":19,"phone":7,"phoneExt":7,"email":7},"Meera Nandhabalan",{"type":190,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[192,194,196,198],{"name":193,"class":6},"The Brain Tumour Charity",{"name":195,"class":6},"University of Oxford",{"name":197,"class":6},"University of Edinburgh",{"name":199,"class":200},"Genomics England","UNKNOWN","100383563","tessa-jowell-brain-matrix---platform-study-100383563",false,"NCT04274283","Tessa Jowell BRAIN MATRIX - Platform Study","A British Feasibility Study of Molecular Stratification and Targeted Therapy to Optimize the Clinical Management of Patients With Glioma by Enhancing Clinical Outcomes, Reducing Avoidable Toxicity, Improving Management of Post-operative Residual & Recurrent Disease and Improving Survivorship","BRAIN MATRIX","Inclusion Criteria:\n\n* Newly diagnosed suspected WHO Grade 2-4 glioma, (as evidenced radiologically) AND suitable for a diagnostic or therapeutic surgical procedure resulting in a tumour sample matched to a blood sample.\n* Patients with progression with known WHO Grade 2-4 glioma (those with available frozen tumour will be prioritised for detailed genomic analysis).\n* Valid written informed consent for the study.\n\nExclusion Criteria:\n\n* Primary spinal cord tumours\n* Active treatment of other malignancy\n* Contraindication to MRI\n* Patients without standard of care imaging available","ALL","16 Years",{"count":212,"type":213},1000,"ESTIMATED","5 Years","OBSERVATIONAL","The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis. A large network of clinical hubs across the United Kingdom, with expertise in managing patients with brain tumours, will be developed. Once established this infrastructure will facilitate the rapid introduction of clinical trials testing targeted therapies tailored to the genetic changes of an individual's tumour.",[218],"Glioma","2026-04-29",{"date":221,"type":222},"2026-05-05","ACTUAL",{"date":224,"type":222},"2020-11-24",{"date":226,"type":213},"2028-02",{"name":5,"class":6},14]