[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590062":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":32,"locations":38,"responsibleParty":57,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":31,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":40,"whyStopped":31,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Northwestern University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Uncertainty-focused single session intervention","EXPERIMENTAL","This is a digital, self-guided SSI that teaches adults about tolerating and embracing uncertainty in their life. The SSI is based on five elements: 1. An introduction the concept of neuroplasticity; 2. Testimonials from peers describing beliefs that people's thoughts, feelings, and behaviors are malleable, given the brain's capacity for change; 3. Strategies (from cognitive-behavioral therapy) for applying these principles to participants' lives; 4. Further vignettes by peers describing times when they tolerated or embraced uncertainty; 5. An exercise wherein participants provide advice to fictional peers, using newly-gleaned information about uncertainty,",[13],"Behavioral: Uncertainty-focused single session intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Maintaining a healthy lifestyle single session intervention","PLACEBO_COMPARATOR","This is a digital, self-guided SSI that teaches adults about the benefits of maintaining a healthy lifestyle (e.g., proper sleep, diet, exercise), emphasizing recommendations by various bodies (e.g., American Medical Association). It is structurally similar to the uncertainty-focused SSI but is designed to mimic what people would receive in their annual physical with a primary care physician. The goals of this intervention is to encourage participants to identify aspects of a healthy lifestyle, and steps they could take towards a healthier lifestyle. This SSI is designed to control for nonspecific aspects of intervention, including engagement in a computer program, reading and writing exercises, and vignettes from peers.",[19],"Behavioral: Maintaining a healthy lifestyle single session intervention",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Digitally\u002Fcomputer administered 30-minute self-guided intervention for adults ages 25-60",[9],[26],"Uncertainty-focused SSI",{"type":22,"name":15,"description":23,"armGroupLabels":28,"otherNames":29},[15],[30],"Maintaining a healthy lifestyle SSI",null,[33],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Brent I Rappaport, Ph.D.","CONTACT","(312) 585-6603","decisionmaking@northwestern.edu",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Chicago","Illinois","60611","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-87.65005,41.85003,{"lat":50,"lon":49},[53,55],{"name":34,"role":35,"phone":54,"phoneExt":31,"email":37},"(312) 585-6603‬",{"name":34,"role":56,"phone":31,"phoneExt":31,"email":31},"PRINCIPAL_INVESTIGATOR",{"type":56,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Brent Rappaport","Assistant Professor",[61],{"name":62,"class":63},"National Institute of Mental Health (NIMH)","NIH","100590062","test-of-target-engagement-of-ambiguity-aversion-100590062",false,"NCT06962527","Test of Target Engagement of Ambiguity Aversion","Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target Engagement","Inclusion Criteria:\n\n1. Ages 25 to 60\n2. Right-handed\n3. Ability to read and write English\n4. Capacity to provide informed consent\n5. Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)\n\nExclusion Criteria:\n\n1. Personal history of psychosis, mania, or hypomania\n2. Personal history of autism spectrum disorder\n3. IQ \\\u003C 80 as determined by the Wechsler Test of Adult Reading\n4. Head injury with greater than 120 seconds loss of consciousness\n5. Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)\n6. Currently pregnant\n7. Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).",true,"ALL","25 Years","60 Years",{"count":76,"type":77},140,"ESTIMATED","INTERVENTIONAL",[80],"NA","The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.",[83,84,85,86],"Intolerance of Uncertainty","Anxiety","Intolerance of Uncertainty; Anxiety","Depression, Anxiety",[88,89,90,91],"Ambiguity aversion","Intolerance of uncertainty","Computational modeling","EEG\u002FERP","2026-05-21",{"date":94,"type":95},"2026-05-26","ACTUAL",{"date":97,"type":95},"2025-07-07",{"date":99,"type":77},"2029-12-31",{"name":5,"class":6},1]