[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533105":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":52,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Health workers",null,"Health workers with baseline negative interferon gamma release assays",[13],"Diagnostic Test: TB infection testing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","TB infection testing","Diagnostic testing with existing and novel tests to evaluate for TB infection and disease",[9],[21],{"name":22,"affiliation":5,"role":23},"Ruvandhi Nathavitharana, MBBS MPH","PRINCIPAL_INVESTIGATOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+16467152601","rnathavi@bidmc.harvard.edu",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"Grant Theron, PhD","+27 21 9389693","gtheron@sun.ac.za",[34],{"facility":35,"status":36,"city":37,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Stellenbosch University","RECRUITING","Cape Town","South Africa","ZA",{"type":41,"coordinates":42},"Point",[43,44],18.42322,-33.92584,{"lat":44,"lon":43},[47,48],{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},{"name":49,"role":26,"phone":50,"phoneExt":10,"email":51},"Ananja Van der Westhuizen","+27 76 173 7478","ananjavdw@gmail.com",{"type":23,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ruvandhi Nathavitharana","Assistant Professor of Medicine",[56],{"name":57,"class":6},"University of Stellenbosch","100533105","testing-health-workers-at-risk-to-advance-our-understanding-of-tb-infection-100533105",false,"NCT06221488","Testing Health Workers At Risk to Advance Our Understanding of TB Infection","THWART-TB: Testing Health Workers At Risk to Advance Our Understanding of TB Infection","THWART-TB","Inclusion Criteria:\n\n* ≥18 years old\n* Health worker\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Prior history of TB or known prior positive IGRA\n* Current or prior history of taking anti-TB treatment","ALL","18 Years","100 Years",{"count":70,"type":71},300,"ESTIMATED","OBSERVATIONAL","It has been estimated that 1.7 billion people have tuberculosis (TB) infection; yet current tests are unable to predict which people are at highest risk of developing TB disease, which can be life-threatening. THWART-TB is a prospective longitudinal cohort study of health workers (HWs) in Cape Town, South Africa, where our preliminary data reveals HWs have a high annual TB infection risk (34%). This cohort, who will undergo frequent serial evaluation (every 3 months) with a combination of novel assays never previously evaluated together, presents a unique opportunity to evaluate immune responses at the time of initial infection and to characterize the dynamic profile of these immune responses over time in a high-risk population. The knowledge generated will improve our understanding of TB infection and help to identify which people exposed to TB may remain at risk, enabling us to better target preventive strategies.",[75,76],"Tuberculosis","Tuberculosis Infection",[75,78,79,80],"TB","TB infection","Health worker","2025-05-20",{"date":83,"type":84},"2025-05-23","ACTUAL",{"date":86,"type":84},"2024-01-15",{"date":88,"type":71},"2029-12-31",{"name":5,"class":6},1]