[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607651":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":53,"responsibleParty":72,"collaborators":30,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":30,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":55,"whyStopped":30,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Real stimulation - Randomized","EXPERIMENTAL","Four consecutive days (2 sessions for 20 minutes each day for a total of 8 sessions) of this blinded stimulation.",[13],"Device: HD-tDCS sessions",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham stimulation - Randomized","SHAM_COMPARATOR",[18],"Device: Sham HD-tDCS sessions",{"label":20,"type":10,"description":21,"interventionNames":22},"Real stimulation - post randomized treatment","Participants that agree to this will have up to 26 weeks of additional HD-tDCS sessions at home or in-person.",[23],"Device: HD-tDCS sessions - Open-label (after randomized treatment)",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","HD-tDCS sessions","This project translates decades of observational neuroimaging research into a biologically plausible stimulation target (i.e., DAN) and uses functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) to plan personalized brain stimulation and to ensure target engagement. When available; those not MRI compatible will receive a standard montage with per channel amplitudes of up to 5 milliamperes (mA) or a montage derived from other imaging methods. Participants will receive 4 days of HD-tDCS sessions in person. During these sessions participants will have electrodes placed on different areas of the head and held in place with headgear. Participants may also have memory and thinking tests during and after the sessions as well as questionnaires about the experience. Additionally, on the fourth day participants may have repeat immersive virtual reality (iVR) as well as other study activities.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Sham HD-tDCS sessions","Participants will receive 4 days of sham HD-tDCS sessions in person. During these sessions participants will have electrodes placed on different areas of the head and held in place with headgear. Participants may also have memory and thinking tests during and after the sessions as well as questionnaires about the experience. Additionally, on the fourth day participants may have repeat immersive virtual reality (iVR) as well as other study activities.",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"HD-tDCS sessions - Open-label (after randomized treatment)","Optional 26 weeks of additional HD-tDCS sessions. Participants can complete up to 5 days per week, but most people will complete about 3 days per week. The study team may also collect audio recordings of these sessions. Participants can complete this in person or at-home via using a secure, HIPAA-compliant videoconferencing with the supervision of a research staff member. Participant's that decide to complete the additional sessions at home, a research staff member will train a study partner during the first 4 HD-tDCS sessions in the office. This option may not be available or appropriate for all participants and the study team member will discuss this with participant's and study partners.",[20],[40],{"name":41,"affiliation":5,"role":42},"Benjamin Hamstead, PhD","PRINCIPAL_INVESTIGATOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Stephen Schlaefflin, BS","CONTACT","734-936-7360","schlst@umich.edu",{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},"Eileen Robinson, RN-BC","734-763-1356","robinsoe@umich.edu",[54],{"facility":5,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-83.74088,42.27756,{"lat":65,"lon":64},[68,69,70],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},{"name":71,"role":42,"phone":30,"phoneExt":30,"email":30},"Benjamin Hampstead, PhD",{"type":42,"investigatorFullName":71,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Professor","100607651","testing-personalized-high-definition-transcranial-direct-current-stimulation-hd-tdcs-as-a-treatment-of-posterior-cortical-atrophy-100607651",false,"NCT07191327","Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy","Testing Personalized High Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy","PCA","Inclusion Criteria:\n\n* Diagnosis or symptoms consistent with PCA\n* Fluent in English\n* HD-tDCS compatible\n* Stable on relevant medications for at least approximately 4 weeks prior to study enrollment\n* If completing any additional, optional, long-term study visits in a remote location (i.e., not our office), a study partner is required in order to administer HD-tDCS. Those choosing to return to our office may have, but are not required to have, a study partner.\n\nExclusion Criteria:\n\n* Other relevant neurological disease (e.g., epilepsy) or injuries (e.g., large vessel stroke, moderate-severe traumatic brain injury) viewed as primary to deficits since these could interfere with etiologic considerations and confound study results\n* Active, relevant psychiatric conditions (e.g., bipolar disorder, schizophrenia) since the symptoms of these conditions may confound study participation.\n* A recent (e.g., within the past 2 years) significant history of, or current, alcohol or drug abuse\u002Fdependence. Remote history of abuse\u002Fdependence is not exclusionary as long as it is not considered to be the primary etiology for visuospatial deficits.\n* Women that are lactating\u002Fbreastfeeding, pregnant, or may potentially be pregnant will be excluded from the study.","ALL","50 Years",{"count":85,"type":86},50,"ESTIMATED","INTERVENTIONAL",[89],"NA","This study is being completed to learn if high-definition transcranial direct current stimulation (HD-tDCS) has an effect on visual and thinking abilities in persons with posterior cortical atrophy (PCA). Participants will be randomized to receive real or sham HD-tDCS (8 sessions over 4 days).\n\nFollowing the randomized treatment, participants will have optional open-label phase with real HD-tDCS up to 26 weeks and other possible testing.",[92],"Posterior Cortical Atrophy",[94,95,96,97,98,99,100,101,102],"HD-tDCS","Functional Magnetic resonance imaging (fMRI)","Positron emission tomography\u002Fcomputerized tomography","Memory and thinking testing","Computerized tests","Questionnaires","Blood draws","Eye tracking and vision tests","Functional Near Infrared Spectroscopy","2026-06-29",{"date":105,"type":106},"2026-06-30","ACTUAL",{"date":108,"type":106},"2026-01-28",{"date":110,"type":86},"2029-07-31",{"name":5,"class":6},1]