[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534105":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":46,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":41,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":41,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":48,"whyStopped":41,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Reading","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin-B6","EXPERIMENTAL","Participants will consume one high-dose Vitamin B6 100 mg tablet orally once daily for one month. Vitamin B6 will be provided as Pyridoxal-5'-Phosphate (PLP)",[13],"Dietary Supplement: Pyridoxal 5'-Phosphate (100 mg)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Participants will consume a Placebo tablet matching the appearance of the Vitamin B6 tablets in the Experimental arm orally once daily for one month.",[19],"Other: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Pyridoxal 5'-Phosphate (100 mg)","100 mg Pyridoxal 5'-Phosphate tablet once daily with food",[9],[27],"Vitamin B6",{"type":6,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Placebo tablet once daily",[15],[32],"Control group",[34],{"name":35,"affiliation":5,"role":36},"Dr David T Field, PhD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","+441183785004",null,"d.t.field@reading.ac.uk",{"name":44,"role":39,"phone":41,"phoneExt":41,"email":45},"Alex Cameron, MSc","a.cameron@pgr.reading.ac.uk",[47],{"facility":5,"status":48,"city":49,"state":41,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Reading","RG6 6AL","United Kingdom","UK",{"type":54,"coordinates":55},"Point",[56,57],-0.97113,51.45625,{"lat":57,"lon":56},[60],{"name":61,"role":39,"phone":62,"phoneExt":41,"email":42},"David Field","0118 378 8523",{"type":36,"investigatorFullName":61,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Associate professor",[66],{"name":67,"class":68},"INNOPURE","UNKNOWN","100534105","testing-the-efficacy-of-100mg-vitamin-b6-daily-for-sensory-reactivity-in-autism-100534105",false,"NCT06234501","Testing the Efficacy of 100mg Vitamin-B6 Daily for Sensory Reactivity in Autism","Testing the Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism","Inclusion Criteria:\n\n* Between the ages of 18 to 60\n* With a diagnosis of autism\n\nExclusion Criteria:\n\n* Taking any supplement that contains more than 2mg of Vitamin B6 or taking GABA agonist drugs\n* Have a medical history of peripheral neuropathy\n* lactose intolerance (placebo tablet is lactose based)","ALL","18 Years","60 Years",{"count":80,"type":81},40,"ESTIMATED","INTERVENTIONAL",[84],"NA","This clinical trial aims to explore the effect of Vitamin B6 supplementation on anxiety sensory hyperreactivity in autistic adults. Researchers will compare a placebo group to high-dose Vitamin-B6 to see if vitamin B6 reduce anxiety and sensory reactivity differences in autism.",[87],"Autism",[27,89,90,91,87],"Sensory Hyperreactivity","GABA","Excitation-Inhibition Balance","2026-03-09",{"date":94,"type":95},"2026-03-11","ACTUAL",{"date":97,"type":95},"2024-11-08",{"date":99,"type":81},"2026-07",{"name":5,"class":6},1]