[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631072":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":26,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":26,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":26,"overallStatus":60,"whyStopped":26,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":26},{"fullName":5,"class":6},"Shaanxi Normal University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Unconscious Reactivation","EXPERIMENTAL","Participants in this experimental arm will undergo subliminal (unconscious) reactivation of trauma-related memories. Trauma cues are presented strictly below the threshold of conscious awareness to minimize psychological distress, while theoretically aiming to trigger the destabilization of the target memory.",[13],"Behavioral: Subliminal Reactivation",{"label":15,"type":16,"description":17,"interventionNames":18},"No Reactivation Control","SHAM_COMPARATOR","Participants in this control arm will not undergo trauma memory reactivation. This condition is designed as a sham comparator to match the overall timing and structure of the experimental arms, isolating the specific effect of memory reactivation and controlling for the nonspecific effects of task engagement.",[19],"Behavioral: Computer-based Visuospatial Task (Tetris)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Subliminal Reactivation","In each intervention session, participants are exposed subliminally to trauma-related cues and then complete a computerized visuospatial task (Tetris) with mental rotation instructions.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Computer-based Visuospatial Task (Tetris)","A computerized visuospatial task (Tetris) with mental rotation instructions.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Zhu Zijian","CONTACT","+86 13572494696","zhuzijian0203@snnu.edu.cn",{"type":38,"investigatorFullName":33,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Associate Professor","100631072","tetris-intervention-following-subliminal-reactivation-for-intrusive-memories-100631072",false,"NCT07495917","Tetris Intervention Following Subliminal Reactivation for Intrusive Memories","A Tetris Intervention Following Subliminal Reactivation for Reducing Intrusive Memories in Trauma-exposed Individuals: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Meet DSM-5 PTSD Criterion A (eg, exposure to actual or threatened death). Have experienced one or more traumatic events.\n2. Experienced five or more intrusive memories during the baseline week.\n3. Have internet access and have access to a personal computer.\n4. Be willing to provide consent and able to complete study procedures and be contacted by the study team.\n\nExclusion Criteria:\n\n1. Have fewer than five intrusive memories during the baseline week.\n2. A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.\n3. Have severe substance dependence.","ALL","18 Years","50 Years",{"count":51,"type":52},106,"ESTIMATED","INTERVENTIONAL",[55],"NA","Post-Traumatic Stress Disorder (PTSD) is characterized by recurrent, intrusive memories of traumatic events that cause significant distress and functional impairment. Although trauma-focused treatments are effective, they typically require deliberate recollection of traumatic experiences, which can be distressing and may contribute to treatment avoidance or dropout.\n\nIn previous experimental studies conducted with healthy participants, we demonstrated that unconscious reactivation of trauma-related cues, followed-after a brief delay corresponding to the memory reconsolidation window-by a visuospatial interference task (Tetris gameplay), reduced the frequency and emotional intensity of intrusive memories. These findings suggest that memory representations may be modifiable during reconsolidation without requiring conscious recall.\n\nBuilding on this work, the present randomized controlled trial (RCT) aims to evaluate the clinical efficacy and tolerability of this reconsolidation-based intervention in trauma-exposed individuals experiencing five or more intrusive memories per week.",[58,59],"Post-traumatic Stress Disorder (PTSD)","Intrusive Memories of Traumatic Event(s)","NOT_YET_RECRUITING","2026-03-31",{"date":63,"type":64},"2026-04-06","ACTUAL",{"date":66,"type":52},"2026-04-10",{"date":68,"type":52},"2027-07-30",{"name":5,"class":6}]