[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608950":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":24,"locations":23,"responsibleParty":30,"collaborators":23,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":38,"eligibilityCriteria":39,"healthyVolunteers":34,"sex":40,"minAge":41,"maxAge":23,"enrollmentInfo":42,"targetDuration":23,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":23,"overallStatus":51,"whyStopped":23,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":23},{"fullName":5,"class":6},"London North West Healthcare NHS Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TXI","ACTIVE_COMPARATOR","Participants allocated to the \"TXI\" group undergo withdrawal using Texture and Colour Enhancement Imaging",[13],"Diagnostic Test: TXI",{"label":15,"type":6,"description":16,"interventionNames":17},"Dye","Participants allocated in the \"Dye\" group receive withdrawal with Dye chromoendoscopy.",[13],[19],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"DIAGNOSTIC_TEST","Participants allocated to the \"TXI\" group undergo withdrawal using Texture and Colour Enhancement Imaging, while those in the \"Dye\" group receive withdrawal with Dye chromoendoscopy. Both procedures follow standardized protocols outlined in the study design.",[15,9],null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Jonathan Landy, Consultant Gastroenterologist","CONTACT","020 8869 544","Jonathan.Landy@nhs.net",{"type":31,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100608950","texture-and-colour-enhancement-imaging-txi-versus-dye-chromoendoscopy-for-dysplasia-detection-in-ibd-surveillance-100608950",false,"NCT07208214","Texture and Colour Enhancement Imaging (TXI) Versus Dye Chromoendoscopy for Dysplasia Detection in IBD Surveillance.","A Randomised Parallel-group Study of Texture and Colour Enhancement Imaging (TXI) Versus Dye Chromoendoscopy for Dysplasia Detection in IBD Surveillance.","TXIorDyE","Inclusion Criteria:\n\n* Patients \\>16 with inflammatory bowel disease undergoing surveillance colonoscopy.\n\n  * Patients with Crohn's (L2\u002FL3 Montreal classification) with \\>50% colonic involvement\n  * Patients with ulcerative colitis with Extensive or left sided disease (E3 or E2 Montreal classification) for at least 8 years or a diagnosis of Primary sclerosing cholangitis concomitant with IBD.\n\nExclusion Criteria:\n\n* The participant may not enter the study if ANY of the following apply:\n\n  * Disease duration \\\u003C8 years unless a diagnosis of PSC\n  * Incomplete colonoscopy\n  * BBPS \\\u003C6 or \\\u003C2 in any segment\n  * MES ≥2 or any variable of the SES-CD is ≥2 or any stenosis for \\>10cm segment (above the rectum)\n  * Previous colorectal resection\n  * Thrombocytopaenia (platelet count \\\u003C50) or Coagulopathy precluding biopsy\n  * Anticoagulation that has not been held appropriately prior to the procedure (must be held at least the morning of the procedure).\n  * Allergy to Indigo Carmine\n  * Pregnancy\n  * Unable or unwilling to consent to study participation","ALL","18 Years",{"count":43,"type":44},242,"ESTIMATED","INTERVENTIONAL",[47],"NA","In individuals with inflammatory bowel disease (IBD), bowel cancer can develop from abnormal cell changes (dysplasia). Regular colonoscopies are recommended to identify these early changes, which can be difficult to detect because they are often small and subtle. Dye-based imaging has been used to improve detection, but it requires additional preparation and time. Texture and Colour Enhancement Imaging (TXI) is a newer method available in clinical practice that adjusts brightness, colour, and texture on high-definition cameras. This study will compare TXI with dye-based imaging to assess which approach detects precancerous changes more effectively in patients with IBD.",[50],"IBD","NOT_YET_RECRUITING","2025-09-26",{"date":54,"type":55},"2025-10-06","ACTUAL",{"date":57,"type":44},"2025-10-01",{"date":59,"type":44},"2027-07-01",{"name":5,"class":6}]