[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542117":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":130,"collaborators":133,"id":137,"slug":138,"hasResults":139,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":10,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":145,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":10,"studyType":151,"phases":10,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":117,"whyStopped":10,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":168},{"fullName":5,"class":6},"Mahidol University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ATTR Cardiomyopathy",null,"Patients diagnosed with ATTR-CM (Transthyretin cardiomyopathy)",[13],"Other: No intervention",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"No intervention",[9],[19],{"name":20,"affiliation":21,"role":22},"Rungroj Krittayaphong, MD, FESC, FACC","Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Kanchalaporn Jirataiporn, B.N.S.","CONTACT","0635153519","kanchalaporn.jir@mahidol.ac.th",[30,46,55,70,79,91,103,115],{"facility":31,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Faculty of Medicine at Chulalongkorn University","NOT_YET_RECRUITING","Bangkok","Thailand","TH",{"type":37,"coordinates":38},"Point",[39,40],100.50144,13.75398,{"lat":40,"lon":39},[43,45],{"name":44,"role":26,"phone":10,"phoneExt":10,"email":10},"Sarinya Puwanant, MD",{"name":44,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":47,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":48,"geoPoint":50,"contacts":51},"Faculty of Medicine Ramathibodi hospital, Mahidol University",{"type":37,"coordinates":49},[39,40],{"lat":40,"lon":39},[52,54],{"name":53,"role":26,"phone":10,"phoneExt":10,"email":10},"Teerapat Yingchoncharoen, MD",{"name":53,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":56,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"Faculty of Medicine Siriraj Hospital, Mahidol University",{"type":37,"coordinates":58},[39,40],{"lat":40,"lon":39},[61,63,65,68],{"name":62,"role":26,"phone":10,"phoneExt":10,"email":10},"Kanchalaporn Jirataiporn, B.N.S",{"name":64,"role":22,"phone":10,"phoneExt":10,"email":10},"Srisakul Chirakarnjanakorn, MD",{"name":66,"role":67,"phone":10,"phoneExt":10,"email":10},"Adisak Maneesai, MD","SUB_INVESTIGATOR",{"name":69,"role":67,"phone":10,"phoneExt":10,"email":10},"Porntera Sethalao, MD",{"facility":71,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"Phramongkutklao Hospital",{"type":37,"coordinates":73},[39,40],{"lat":40,"lon":39},[76,78],{"name":77,"role":26,"phone":10,"phoneExt":10,"email":10},"Hutsaya Prasitdumrong, MD",{"name":77,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":80,"status":32,"city":81,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Faculty of Medicine Chiang Mai University","Chiang Mai",{"type":37,"coordinates":83},[84,85],98.98468,18.79038,{"lat":85,"lon":84},[88,90],{"name":89,"role":26,"phone":10,"phoneExt":10,"email":10},"Arintaya Phrommintikul, MD",{"name":89,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":92,"status":32,"city":93,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Queen Sirikit Heart Center of The Northeast","Khon Kaen",{"type":37,"coordinates":95},[96,97],102.833,16.44671,{"lat":97,"lon":96},[100,102],{"name":101,"role":26,"phone":10,"phoneExt":10,"email":10},"Vichai Senthong, MD",{"name":101,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":104,"status":32,"city":105,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Faculty of Medicine, Thammasat University","Pathum Thani",{"type":37,"coordinates":107},[108,109],100.53049,14.01346,{"lat":109,"lon":108},[112,114],{"name":113,"role":26,"phone":10,"phoneExt":10,"email":10},"Adisai Buakhamsri, MD",{"name":113,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":116,"status":117,"city":118,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Prince of Songkla University","RECRUITING","Songkhla",{"type":37,"coordinates":120},[121,122],100.5951,7.19882,{"lat":122,"lon":121},[125,127,128],{"name":126,"role":26,"phone":10,"phoneExt":10,"email":10},"Thammarak Songsangjinda, MD",{"name":126,"role":22,"phone":10,"phoneExt":10,"email":10},{"name":129,"role":67,"phone":10,"phoneExt":10,"email":10},"Ply Chichareon, MD, PhD",{"type":22,"investigatorFullName":131,"investigatorTitle":132,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Rungroj Krittayaphong","Professor",[134],{"name":135,"class":136},"Pfizer","INDUSTRY","100542117","thailand-attr-cm-registry-100542117",false,"NCT06338696","Thailand ATTR-CM Registry","Thailand Transthyretin Amyloid Cardiomyopathy Registry","Inclusion Criteria:\n\n* Age \\> 18 years.\n* All patients diagnosed with ATTR-CM (Transthyretin cardiomyopathy) who have either symptomatic or asymptomatic must have evidence of cardiac involvement by echocardiogram as defined by left ventricle wall thickness of ≥ 12 mm and with at least one of the following criteria:\n* Positive scintigraphy by 99mTC-DPD \\[99mTC-3,3-diphosphono-1,2-propano-dicarboxylic acid\\] or 99mTC-PYP \\[Pyrophosphate\\] or 99mTC-HMDP \\[hydroxymethylene diphosphate\\] with Perugini grade ≥ 2 and\u002For H\u002FCL (heart to contralateral lung) ratio \\> 1.5\n* Positive scintigraphy by 99mTC-DPD \\[99mTC-3,3-diphosphono-1,2-propano-dicarboxylic acid\\] or 99mTC-PYP \\[Pyrophosphate\\] or 99mTC-HMDP \\[hydroxymethylene diphosphate\\] with Perugini grade 1 and positive cardiac biopsy tissue confirmed which Congo red stain ≥ 4 sites\n* Positive scintigraphy by 99mTC-DPD \\[99mTC-3,3-diphosphono-1,2-propano-dicarboxylic acid\\] or 99mTC-PYP \\[Pyrophosphate\\] or 99mTC-HMDP \\[hydroxymethylene diphosphate\\] with Perugini grade 1 with positive non-cardiac biopsy tissue confirmed by Congo red stain\n* Abnormalities on CMR (Cardiac MRI) \\[Subendocardium LGE (late gadolinium enhancement) and\u002For elevated native T1 value and\u002For increased extracellular volume (ECV \\> 0.4)\\] with positive non-cardiac and\u002For cardiac tissue biopsy confirmed by Congo red stain\n\nExclusion Criteria:\n\n* Diagnosed with amyloidosis caused by proteins other than transthyretin (light chain Amyloidosis, etc.)\n* Diagnosed with secondary amyloidosis",true,"ALL","18 Years","100 Years",{"count":149,"type":150},105,"ESTIMATED","OBSERVATIONAL","The investigators of this registry aim to study the natural history, clinical presentation, characteristics, and imaging findings of patients diagnosed with ATTR amyloidosis in Thailand longitudinally. This will enable the investigators to study this disease in depth. With a better understanding, the investigators can aim to develop early screening programs for at-risk patients, raising awareness among non-cardiologists. As amyloid-specific therapies have now become available in Thailand, the findings of this registry can be helpful for epidemiological studies in Thailand.",[154],"Transthyretin Amyloid Cardiomyopathy (ATTR-CM)",[156,157,158],"Transthyretin amyloid cardiomyopathy (ATTR-CM)","Heart Failure","Cardiomyopathy","2025-05-05",{"date":161,"type":162},"2025-05-08","ACTUAL",{"date":164,"type":162},"2024-07-30",{"date":166,"type":150},"2030-06-30",{"name":5,"class":6},8]