[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631119":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":32,"locations":32,"responsibleParty":42,"collaborators":32,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":32,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":74,"whyStopped":32,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":32},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Electroacupuncture (EA) Group","EXPERIMENTAL","Participants receive active electroacupuncture at bilateral acupoints ST36, ST37, SP6, LI4, and PC6. A continuous wave frequency of 5 Hz is applied for 30 minutes. Treatment occurs once daily: one session on preoperative day 1 and three sessions on postoperative days 1 to 3.",[13,14],"Device: Electroacupuncture (EA)","Procedure: Enhanced Recovery After Surgery (ERAS) Protocol",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham Electroacupuncture (SA) Group","SHAM_COMPARATOR","Participants receive superficial needling (2-3 mm depth) at five non-acupoint locations. Electrodes are attached to a disconnected electroacupuncture device (no current delivered). The treatment schedule and duration (30 mins) are identical to the EA group",[20,14],"Device: Sham Electroacupuncture (SA)",{"label":22,"type":23,"description":24,"interventionNames":25},"Standard Care Group","PLACEBO_COMPARATOR","Participants receive perioperative care according to the standard modified Enhanced Recovery After Surgery (ERAS) protocol without any acupuncture intervention.",[14],[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Electroacupuncture (EA)","A licensed practitioner will administer electroacupuncture at five bilateral acupoints: ST36 (Zusanli), ST37 (Shangjuxu), SP6 (Sanyinjiao), LI4 (Hegu), and PC6 (Neiguan). Sterile acupuncture needles will be inserted to a depth of 15-30 mm to elicit the \"deqi\" sensation. An electroacupuncture device will deliver a continuous wave at a frequency of 5 Hz, with intensity adjusted to individual tolerance. Each session lasts 30 minutes. A total of 4 sessions will be performed: one session the day before surgery and three sessions on postoperative days 1, 2, and 3.",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Sham Electroacupuncture (SA)","Participants receive superficial needling (2-3 mm depth) at five non-acupoint locations, anatomically distinct from the true acupoints. To maintain blinding, visually identical needles and a sham electroacupuncture device will be used. While electrodes are attached to the needles, the internal wiring of the stimulator is disconnected, ensuring no electrical current is delivered. The treatment timing (30 minutes per session) and overall schedule (4 sessions total) are identical to the Electroacupuncture group.",[16],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"PROCEDURE","Enhanced Recovery After Surgery (ERAS) Protocol","Standardized perioperative care including patient education, preoperative mechanical bowel preparation with oral antibiotics, minimally invasive surgical approach (laparoscopic or robotic), restrictive fluid management, early removal of nasogastric tube and urinary catheter, multimodal analgesia, and early postoperative mobilization and oral intake.",[9,16,22],{"type":43,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100631119","the-acure-trial-acupuncture-for-colorectal-recovery-100631119",false,"NCT07496528","The ACURE Trial: Acupuncture for Colorectal Recovery","Acupuncture for Colorectal sUrgery Recovery Enhancement: A Randomized Controlled Trial Evaluating Gastrointestinal Functional Recovery After Minimally Invasive Resection","ACURE","Inclusion Criteria:\n\n* Histologically confirmed colorectal cancer requiring scheduled curative-intent resection.\n* Age between 18 and 79 years, inclusive.\n* Ability to understand the study protocol and provide written informed consent.\n* American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* History of major abdominal surgery within the past 4 weeks.\n* Receipt of chemotherapy or radiotherapy within the past 6 months.\n* History of organ transplantation with rejection episodes within the past 30 days.\n* Presence of active infection (e.g., tuberculosis, sepsis, peritonitis).\n* Positive for hepatitis B, hepatitis C, or HIV with an uncontrolled viral load.\n* Severe malnutrition, defined as a Nutritional Risk Screening (NRS 2002) score ≥ 3.\n* History of total colectomy or requirement for ileorectal anastomosis.\n* Requirement for multivisceral resection due to tumor invasion.\n* Scheduled for prophylactic stoma creation.\n* Moderate to severe cognitive impairment, epilepsy, or uncontrolled neurological disorders.\n* Active psychiatric illness (e.g., bipolar disorder, schizophrenia) that may interfere with study compliance.\n* Severe cardiopulmonary insufficiency (e.g., New York Heart Association \\[NYHA\\] class IV heart failure or requirement for long-term oxygen therapy).\n* Presence of open wounds, skin infections, or known allergies at or near the designated acupuncture sites.\n\nHistory of adverse reactions to acupuncture, including syncope (fainting) or needle phobia.\n\nParticipation in another clinical trial within the past 6 months.\n\nAnticipated inability to complete the study protocol due to physical, psychological, or logistical reasons.","ALL","18 Years","80 Years",{"count":56,"type":57},240,"ESTIMATED","INTERVENTIONAL",[60],"NA","Purpose:\n\nThe goal of this clinical trial is to evaluate whether electroacupuncture (EA) can accelerate the recovery of bowel function in patients undergoing minimally invasive surgery for colorectal cancer.\n\nMain Questions to be Answered:\n\nDoes electroacupuncture reduce the time to the first bowel movement after surgery compared to standard care or a \"sham\" (placebo) treatment?\n\nCan electroacupuncture improve overall gastrointestinal tolerance and reduce postoperative discomfort?\n\nStudy Design:\n\nParticipants will be randomly assigned to one of three groups:\n\nElectroacupuncture Group: Receives active electrical stimulation at specific acupuncture points.\n\nSham Acupuncture Group: Receives superficial needling at non-treatment points with no electrical current to serve as a placebo.\n\nStandard Care Group: Receives standard hospital recovery protocols (ERAS) without acupuncture.\n\nAll treatments will consist of four 30-minute sessions: one before surgery and three on the days following the procedure. Researchers will compare the three groups to see if the electroacupuncture group experiences a faster return of digestive function.",[63,64,65,66],"Colorectal Neoplasms","Ileus Postoperative","Postoperative Complication","Gastrointestinal Motility",[68,69,70,71,72,73],"electroacupuncture","acupuncture therapy","colorectal cancer","enhanced recovery after surgery","minimally invasive surgery","postoperative ileus","NOT_YET_RECRUITING","2026-03-31",{"date":77,"type":78},"2026-04-06","ACTUAL",{"date":80,"type":57},"2026-04-01",{"date":82,"type":57},"2029-05-31",{"name":5,"class":6}]