[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624744":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":30,"locations":39,"responsibleParty":59,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":29,"enrollmentInfo":77,"targetDuration":29,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":94,"whyStopped":29,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"KU Leuven","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Evening Group","EXPERIMENTAL","Thirty participants will complete four single experimental exercise sessions (of which one control session) in the evening (5-8 PM) in random order within a minimum of four weeks and a maximum of eight weeks separated by at least one week between two sessions.",[13],"Behavioral: Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Morning Group","Thirty participants will complete four single experimental exercise sessions (of which one control session) in the morning (8-11 AM) in random order within a minimum of four weeks and a maximum of eight weeks separated by at least one week between two sessions.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Exercise","Participants will complete four single experimental exercise sessions in a randomized order within a maximum of eight weeks, separated by at least 1 week (7 days) between two sessions. Group allocation will be based on personal preference with 30 patients performing all exercise sessions in the morning (8-11 AM) and 30 patients performing all exercise sessions in the evening (5-8 PM). Each individual will perform his\u002Fher session on the same time of day and will be asked to go to bed at a similar time.\n\nThe four bouts of exercise are defined according to the following FITT-parameters:\n\n* MCT: 1 session of indoor cycling at 65% of VO2-reserve, 45 min, aerobic endurance\n* HIIT: 1 session of indoor cycling, 4 min at 85% of VO2-reserve interspersed by 3 min at 60% of the VO2-reserve, 28 min, aerobic exercise\n* IRT: 1 session of wall squatting, 6 x 1 min (with 2 min seated rest between each set), specific knee joint angle corresponding to 95% of HR-reserve\n* CONTROL: Seated rest for 30",[9,15],[25,26,27,28],"Moderate continuous training","High intensity interval training","Wall squatting","Isometric resistance training",null,[31,36],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"Véronique Cornelissen, MSc, PhD, Associate Professor","CONTACT","+32 16 32 91 52","veronique.cornelissen@kuleuven.be",{"name":37,"role":33,"phone":29,"phoneExt":29,"email":38},"Marie Renier, MSc","marie.renier@kuleuven.be",[40],{"facility":41,"status":29,"city":42,"state":29,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"UZ Leuven\u002FKU Leuven","Leuven","3000","Belgium","BE",{"type":47,"coordinates":48},"Point",[49,50],4.70093,50.87959,{"lat":50,"lon":49},[53,55,57],{"name":37,"role":33,"phone":54,"phoneExt":29,"email":38},"+32 16 34 25 48",{"name":32,"role":56,"phone":29,"phoneExt":29,"email":29},"PRINCIPAL_INVESTIGATOR",{"name":37,"role":58,"phone":29,"phoneExt":29,"email":29},"SUB_INVESTIGATOR",{"type":56,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Véronique Cornelissen","Associate Professor, Head of the Research Group for Rehabilitation in Internal Disorders",[63,65],{"name":64,"class":6},"Universitaire Ziekenhuizen KU Leuven",{"name":66,"class":6},"Research Foundation Flanders","100624744","the-acute-effect-of-exercise-type-and-timing-on-ambulatory-blood-pressure-and-intra-ocular-pressure-in-individuals-with-glaucoma-the-achieve-project-100624744",false,"NCT07413614","The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma (The ACHIEVE-project).","The ACHIEVE-project: Advancing Cardiovascular and Ocular Health In Eye Patients. The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma.","ACHIEVE","Inclusion Criteria:\n\n* Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures\n* At least 18 years of age at the time of signing the Informed Consent Form (ICF)\n* Patients with POAG AND \\[elevated BP OR hypertension (Average SBP on office BP and Home BP ≥120 mmHg AND\u002FOR Average DBP on office BP and Home BP ≥70 mmHg 26) with or without the use of anti-hypertensive medication\\]\n* Patients without recent changes in medication and glaucoma care within the past four weeks.\n\nExclusion Criteria:\n\n* Not able to provide informed consent\n* SBP and\u002For DBP are ≥ 150 mmHg and\u002For ≥ 95 mmHg, respectively, on office BP at screening AND on home BP measurement conducted in the week following screening (to identify White Coat Hypertension) to ensure safety. These patients require referral for early treatment.\n* Aberrant cardiopulmonary exercise test (CPET) at screening (Life-threatening arrhythmias, ischemia,…)\n* Unable to perform one or more of the four exercise sessions due to physical and or mental limitations (severe lung disease, musculoskeletal issues, unstable angina,…)\n* Severe osteoarthritis pending knee replacement surgery (these patients may be unable to perform the IRE (i.e. wall squat exercise)\n* Unable to communicate in Dutch\n* Active malignancy\n* Participation in an interventional Trial with an investigational medicinal product (IMP), exercise intervention or device\n* Unwillingness to repeat ABPM\n* Relative contraindications to ABPM: diagnosed atrial fibrillation, nighttime workers, occupational drivers","ALL","18 Years",{"count":78,"type":79},60,"ESTIMATED","INTERVENTIONAL",[82],"NA","ACHIEVE aims to determine whether exercise can be a safe and effective non-drug approach to improve blood pressure control in patients with primary open-angle glaucoma (POAG). Although exercise is a promising and potentially well-accepted therapy, its use in clinical care is limited because the safety and effectiveness of different exercise types (aerobic, isometric, moderate, or high intensity) and timing (morning versus evening) have not been systematically studied in people with POAG and elevated blood pressure.\n\nThis study will evaluate the safety and short-term effects of different exercise modalities and timings on 24-hour ambulatory blood pressure and blood pressure variability in patients with POAG and elevated blood pressure.\n\nIt is hypothesized that:\n\n* Each exercise session will lead to a temporary reduction in blood pressure (post-exercise hypotension).\n* The greatest and longest-lasting reduction will occur after high-intensity aerobic exercise performed in the morning.\n\nIt is also expected that all exercise types and timings will be safe for participants.",[85,86,87],"Glaucoma Open-Angle Primary","Hypertension","Elevated Blood Pressure",[89,26,90,91,25,92,86,93,21],"Ambulatory blood pressure","Isometric Exercise","Intra-ocular pressure","Primary open angle glaucoma","Blood pressure variability","NOT_YET_RECRUITING","2026-02-09",{"date":97,"type":98},"2026-02-17","ACTUAL",{"date":100,"type":79},"2026-04",{"date":102,"type":79},"2027-03",{"name":5,"class":6},1]