[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631047":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":41,"centralContacts":46,"locations":54,"responsibleParty":71,"collaborators":32,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":32,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":32,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":107,"whyStopped":32,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Applied Science & Performance Institute","INDUSTRY",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Alpha Brain","EXPERIMENTAL","Alpha Brain investigational dietary supplement administered as two oral capsules with water",[13],"Dietary Supplement: Alpha Brain proprietary cognitive dietary supplement",{"label":15,"type":16,"description":17,"interventionNames":18},"Alpha Brain 2.0","ACTIVE_COMPARATOR","Alpha Brain 2.0 investigational dietary supplement administered as two oral capsules with water",[19],"Dietary Supplement: Alpha Brain 2.0 proprietary cognitive dietary supplement",{"label":21,"type":22,"description":23,"interventionNames":24},"Control Treatment","PLACEBO_COMPARATOR","Inactive\u002Finert placebo capsules administered as two oral capsules with water",[25],"Dietary Supplement: Controlled Placebo",[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DIETARY_SUPPLEMENT","Alpha Brain proprietary cognitive dietary supplement","Alpha Brain is a proprietary investigational dietary supplement. The formulation contains a combination of dietary ingredients commonly used in cognitive supplement mixes.",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Alpha Brain 2.0 proprietary cognitive dietary supplement","Alpha Brain 2.0 is a proprietary investigational dietary supplement. The formulation contains a combination of dietary ingredients commonly used in cognitive supplements and will be evaluated under double-blind conditions in a randomized, placebo-controlled crossover study.",[15],{"type":28,"name":38,"description":39,"armGroupLabels":40,"otherNames":32},"Controlled Placebo","The placebo consists of an inactive placebo mix administered orally as two capsules.",[21],[42],{"name":43,"affiliation":44,"role":45},"Eric Sikorski, PhD","Applied Science and Performance Institute","PRINCIPAL_INVESTIGATOR",[47,51],{"name":43,"role":48,"phone":49,"phoneExt":32,"email":50},"CONTACT","8138678888","esikorski@theaspi.com",{"name":52,"role":48,"phone":49,"phoneExt":32,"email":53},"Gabe Wilson, PhD","gwilson@theaspi.com",[55],{"facility":56,"status":32,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Applied Science Performance Institute","Tampa","Florida","33634","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-82.45843,27.94752,{"lat":66,"lon":65},[69,70],{"name":43,"role":48,"phone":49,"phoneExt":32,"email":50},{"name":52,"role":48,"phone":49,"phoneExt":32,"email":53},{"type":72,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100631047","the-acute-effects-of-onnit-alpha-brain-on-cognition-and-mood-states-100631047",false,"NCT07495592","The Acute Effects of Onnit Alpha Brain on Cognition and Mood States","The Acute Effects of Onnit Alpha Brain on Cognition and Mood States: A Randomized, Crossover, Double Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Healthy males and females aged 20-59\n* Free of chronic diseases.\n* Able to read and write in English\n* Willing to maintain a habitual diet, supplement routine, and avoid other lifestyle changes during the study period\n* Willingness to meet all study requirements and restrictions. Including willing to arrive in lab in a sleep deprived state (\\\u003C or =5 hours), willing to avoid alcohol consumption 72 hours prior to testing days, and willing to avoid caffeine within 12 hours prior to testing days.\n\nExclusion Criteria:\n\n* Habitual high caffeine consumers (\\> 400 mg\u002Fday) assessed through caffeine assessment tool (Caffeine Consumption Questionnaire, CCQ)\n* Unwilling to wear sleep monitor at night\n* Known diagnosis of any cognitive impairment, cardiovascular, metabolic, endocrine, or renal disease\n* Has fever, or cold like symptoms\n* History of anxiety disorders\n* History of sleep disorders (i.e., insomnia), and habitually short sleepers (\\\u003C5 hours of sleep nightly)\n* History or current malignancy\n* Previous gastrointestinal surgery within the past 12 months\n* No alcohol consumption 72 hours prior to the start of the study\u002Fconsumption of the study product and during the testing days\n* No caffeine consumption within 12 hours prior to the start of the study and during the testing days\n* Sleep medicines, melatonin, or marijuana within 1 week of the start of the study\n* Regular smoker\n* Regular drinker (\\>14 drinks per week)\n* Current use (within the past 4 weeks) of dietary supplements or prescription medicines that may enhance cognitive performance (including, but not limited to L-Theanine, Cat's claw bark extract, Alpha GPC, Toothed clubmoss extract (Huperzine A), Bacopa, Phosphatidylserine, Paraxanthine, Pterostilbene, and Sceletium tortuosum).\n* Current use of prescription medications that may influence cognition (hormone therapies, peptides, etc.)\n* Travel involving time zone change, shift work, or other life events that alter sleep schedule \\>3 hours from the norm one week before the start of the study\n* Any subject with a condition deemed by the investigator or sponsor to potentially interfere with study participation\n* Women who have been pregnant within the past 6-months, are breastfeeding, lactating, or presently planning to become pregnant during the duration of the study",true,"ALL","20 Years","59 Years",{"count":85,"type":86},34,"ESTIMATED","INTERVENTIONAL",[89],"NA","The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive performance, vigilance, and subjective mood in healthy adults compared to placebo during a period of acute sleep deprivation under conditions of controlled sleep deprivation.",[92,93,94,95,96],"Cognitive","Mood and Cognitive Performance","Sleep Deprivation","Executive Function (Cognition)","Fatigue",[9,98,99,100,101,102,103,104,105,106],"Dietary Supplement","Reaction Time","Attention","Vigilance","Mood States","Psychomotor Vigilance Test","Stroop Test","alertness","Executive Function","NOT_YET_RECRUITING","2026-03-30",{"date":110,"type":111},"2026-04-03","ACTUAL",{"date":113,"type":86},"2026-04-16",{"date":115,"type":86},"2026-08-15",{"name":5,"class":6},1]