[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643114":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":52,"collaborators":25,"id":56,"slug":25,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":25,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":77,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Kasr El Aini Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"dexmedetomidine group","ACTIVE_COMPARATOR","patients receiving peripheral nerve blocks for above-knee amputation with dexmedetomidine added to the local anesthetic solution",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"fentanyl group","patients receiving peripheral nerve blocks for above-knee amputation with fentanyl added to the local anesthetic solution",[18],"Drug: Fentanyl (as Citrate)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Dexmedetomidine","Dexmedetomidine added as an adjuvant to the local anesthetic solution during peripheral nerve block for above-knee amputation surgery.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Fentanyl (as Citrate)","Fentanyl added as an adjuvant to the local anesthetic solution during peripheral nerve block for above-knee amputation surgery.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"paula atef gobran kamil, MBBCH, M.SC","CONTACT","0201276604277","paula.atef.gobran.1995@gmail.com",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"tamer ibrahem rouk, MD","01006216826","tamer_rouk@yahoo.com",[41],{"facility":42,"status":25,"city":43,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"KasrELainiH","Cairo","Egypt","EG",{"type":47,"coordinates":48},"Point",[49,50],31.24967,30.06263,{"lat":50,"lon":49},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","paula atef gobran kamil","professor of anesthesiology","100643114",false,"NCT07640516","The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .","The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation : A Randomized Double Blinded Study","Inclusion Criteria:\n\n* \\- Age ≥18 years\n* Both sexes\n* ASA III-IV\n* Documented cardiac disease (e.g., EF \\\u003C 40%, NYHA II or higher)\n* Documented pulmonary disease (e.g., COPD with FEV1 \\\u003C 60%)\n* Scheduled for above-knee amputations\n\nExclusion Criteria:\n\n* Neurological or intellectual disability\n* Drug abuse\n* Allergy to study drugs\n* Pregnancy\n* Contraindications to regional anesthesia (e.g., coagulopathy, local infection)\n* Significant renal or hepatic impairment( plts \\\u003C75000 or INR \\>1.5)\n* Current anticoagulant therapy\n* severe haemodynamically unstability at the time of block performance, defined as map \\> 65 mmhg but achieved by high-dose vasopressors (e.g., norepinephrine ≥ 0.1 mcg\u002Fkg\u002Fmin) after fluid ressuscitation .","ALL","18 Years",{"count":65,"type":66},64,"ESTIMATED","INTERVENTIONAL",[69],"NA","The aim of this study is to compare the analgesic efficacy and safety of dexmedetomidine versus fentanyl as adjuvants to bupivacaine in ultrasound-guided combined supra-inguinal fascia iliaca and proximal sciatic nerve blocks used as a solo anesthetic technique in high-risk patients undergoing unilateral above knee amputation.",[72,73,74],"Analgesia Assessment","Above Knee Amputation","Fentanyl vs Dexmedetomidine",[76],"dexmedetomidine vs fentanyl PNBs AKA","NOT_YET_RECRUITING","2026-06-06",{"date":80,"type":81},"2026-06-10","ACTUAL",{"date":83,"type":66},"2026-07-01",{"date":85,"type":66},"2027-03-01",{"name":5,"class":6},1]