[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100441776":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Severe radiation dermatitis",null,"RTOG\u002FEORTC grade 2 and above",[13],"Radiation: post-operative radiotherapy",{"label":15,"type":10,"description":16,"interventionNames":17},"No or mild radiation dermatitis","RTOG\u002FEORTC grade 0 or 1",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"RADIATION","post-operative radiotherapy","Breast cancer patients who have received reconstructive surgery will receive post-operative radiotherapy.",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Xiaoli Yu, MD, Ph.D","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Wei Shi, MD, Ph.D","CONTACT","+86 18121299680","wei.shi118@foxmail.com",{"name":35,"role":31,"phone":10,"phoneExt":10,"email":36},"Li Zhang, MD","zhangliaaa111@163.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":10},"Fudan University Shanghai Cancer Center","RECRUITING","Shanghai","Shanghai Municipality","200032","China","CN",{"type":47,"coordinates":48},"Point",[49,50],121.45806,31.22222,{"lat":50,"lon":49},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100441776","the-association-between-radiation-dermatitis-and-skin-microbiome-in-breast-cancer-patients-100441776",false,"NCT05032768","The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients","The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients Receiving Radiation After Mastectomy and Reconstructive Surgery","Inclusion Criteria:\n\n1. Female patients\n2. Invasive breast cancer confirmed by pathology\n3. Underwent mastectomy and breast reconstruction\n4. Radiotherapy after breast reconstruction\n5. ECOG score 0-1\n6. Signed informed consent\n\nExclusion Criteria:\n\n1. Previous breast or chest radiotherapy\n2. Other serious skin diseases (systemic lupus erythematosus, skin sclerosis, et al) and cannot receive radiotherapy\n3. Pregnant women\n4. Patients who are unwilling or unable to receive regular follow-up.","FEMALE","18 Years","70 Years",{"count":65,"type":66},100,"ESTIMATED","OBSERVATIONAL","The breast cancer patients who received radiotherapy after mastectomy and breast reconstruction will be enrolled. The skin microbiome before radiotherapy and its changes after radiotherapy will be analyzed systematically to find out whether the skin microbiome is associated with the severity of radiation dermatitis.",[70,71,72,73],"Radiation Dermatitis","Skin Microbiome","Breast Cancer","Reconstructive Surgery","2021-09-01",{"date":76,"type":77},"2021-09-02","ACTUAL",{"date":79,"type":77},"2021-01-01",{"date":81,"type":66},"2026-12-31",{"name":5,"class":6},1]