[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487584":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":35,"centralContacts":40,"locations":47,"responsibleParty":87,"collaborators":90,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":10,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":10,"studyType":107,"phases":10,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":77,"whyStopped":10,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Zhujiang Hospital","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Azoospermia",null,"After an abstinence period of 2-7 days, two basic semen analysis, the absence of spermatozoa",[13],"Other: no intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Oligozoospermia","After an abstinence period of 2-7 days, the total sperm number \\\u003C39\\*10\\^6 per ejaculate or the sperm concentration \\\u003C 15 \\* 10\\^6 per ml",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Asthenozoospermia","After an abstinence period of 2-7 days, the progressive motility (PR) \\\u003C 32%",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Teratozoospermia","After an abstinence period of 2-7 days, the percentage of morphologically normal spermatozoa \\\u003C4%",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Control","After an abstinence period of 2-7 days, the basic semen analysis is normal.",[13],[31],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"no intervention","Observational studies, no intervention",[19,9,27,15,23],[36],{"name":37,"affiliation":38,"role":39},"Hongwei Zhou","Southern Medical University, China","STUDY_CHAIR",[41],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Shuo Wang","CONTACT","13265068619","+86","mywanuo@163.com",[48,66,75],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Guangdong Provincial Fertility Hospital","NOT_YET_RECRUITING","Guangzhou","Guangdong","510000","China","CN",{"type":57,"coordinates":58},"Point",[59,60],113.25,23.11667,{"lat":60,"lon":59},[63],{"name":64,"role":43,"phone":10,"phoneExt":10,"email":65},"Xinzong Zhang","zhangxz0123@163.com",{"facility":67,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":68,"geoPoint":70,"contacts":71},"Guangdong Second Provincial General Hospital",{"type":57,"coordinates":69},[59,60],{"lat":60,"lon":59},[72],{"name":73,"role":43,"phone":74,"phoneExt":45,"email":10},"Tao Jing","13570464923",{"facility":76,"status":77,"city":78,"state":52,"zip":79,"country":54,"countryCode":55,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Zhujiang Hospital of Southern Medical University","RECRUITING","Guanzhou","510280",{"type":57,"coordinates":81},[82,83],113.37117,23.06828,{"lat":83,"lon":82},[86],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},{"type":88,"investigatorFullName":37,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Professor",[91],{"name":92,"class":93},"National Natural Science Foundation of China","OTHER_GOV","100487584","the-association-of-gut-microbiota-and-spermatogenic-dysfunction-100487584",false,"NCT05628987","The Association of Gut Microbiota and Spermatogenic Dysfunction","Inclusion Criteria:\n\n* Aged 18 to 45 years, males\n* Body Mass Index (BMI):18.5-29.9 kg\u002Fm\\^2\n* After an abstinence period of 2-7 days, two abnormal semen analysis, the absence of spermatozoa from both replicates will be included in the azoospermia group, the total sperm number (\\\u003C39\\*10\\^6 per ejaculate) or the sperm concentration ( \\\u003C 15 \\* 10\\^6 per ml) will be oligozoospermia group, the progressive motility (PR) (\\\u003C 32%) will be asthenozoospermia group; the percentage of morphologically normal spermatozoa (\\\u003C4%) will be teratozoospermia group\n* Willing to provide feces, urine, blood samples, able to complete study questionnaires aimed at lifestyle factors (cigarette smoking, high temperature environment and others ) and other data collection instruments (e.g. physical activity, food frequency questionnaire, stress and others)\n\nExclusion Criteria:\n\n* Age \\\u003C 18 or \\> 45 years\n* History of Zocanidin, Vitamin E, antibiotics, clyster, gastrointestinal endoscope in the past 30 days, or other drugs known to interact with semen quality or gut microbiota, history of high alcohol consumption (liquor over 200 ml, beer over 1000 ml) in the past 7 days or drinking every week in the past month\n* A known genetic cause of male factor spermatogenesis dysfunction, including chromosomal or gene disorders (e.g. Y chromosome deletions, CFTR mutation)\n* History of male reproductive system (e.g. testis, epididymis, seminiferous duct and others) damage, surgery, tumor or infection\n* History of Crohn's disease, ulcerative colitis, acute gastrointestinal disease, renal failure, liver cirrhosis, hypoplasia, X-rays exposure and other diseases related to spermatogenic dysfunction, history of intestinal gastrointestinal surgery (exclude appendix surgery)\n* History of psychoses or other mental conditions that would result in cognitive impairment and inability to participate in any part of this study including the informed consent process",true,"MALE","18 Years","45 Years",{"count":105,"type":106},306,"ESTIMATED","OBSERVATIONAL","This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata. The results of the spermatogenic dysfunction, including aspermia, oligozoospermia, asthenozoospermia, and teratozoospermia, will be compared to normal basic semen analysis utilizing the World Health Organization (WHO) semen analysis procedure 5th edition.",[110,9,15,19,23],"Infertility, Male",[112,110,113],"Microbiota","Sperm","2024-07-22",{"date":116,"type":117},"2024-07-24","ACTUAL",{"date":119,"type":117},"2023-02-20",{"date":121,"type":106},"2025-06-30",{"name":5,"class":6},3]