[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100341051":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":47,"centralContacts":52,"locations":61,"responsibleParty":80,"collaborators":10,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":10,"studyType":95,"phases":10,"briefSummary":96,"conditions":97,"keywords":10,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,16,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: Patients suffering from acute myocardial infarction",null,"Patients with positive gadolinium late enhancement and positive intramyocardial oedema in the short CMR have an acute myocardial infarction and will be allocated to group 1.",[13,14,15],"Procedure: Short cardiovascular MRI (CMR)","Procedure: Blood draw","Procedure: Urine (collection over 24h)",{"label":17,"type":10,"description":18,"interventionNames":19},"Group 2: Patients suffering from chronic myocardial infarction","Patients with elevated (≥ 0.015 mg\u002FL) high sensitive troponin T (hsTnT) levels, positive gadolinium late enhancement and\u002For positive myocardial infarction suffer from chronic myocardial infarction or significant coronary stenosis. They will be allocated to group 2 and receive coronary angiography in a timely manner according to clinical routine and current guidelines.",[13,20,14,15],"Procedure: Adenosine-perfusion cardiovascular MRI (CMR)",{"label":22,"type":10,"description":23,"interventionNames":24},"Group 3: Patients suffering from stunned neurogenic myocardium","Patients with elevated (≥ 0.015 mg\u002FL) high sensitive troponin T (hsTnT) levels and presence of wall motion abnormalities (WMA) have potential WMA due to neurogenic myocardial stunning. They will be allocated to group 3.\n\nThese patients will undergo a follow-up CMR without adenosine-perfusion after 3 months to confirm improvement\u002Fnormalization of WMA.\n\nPatients with normal (\\\u003C 0.015mg\u002FL) hsTnT levels and presence of WMA will also be allocated to group 3.",[13,20,14,15],{"label":26,"type":10,"description":27,"interventionNames":28},"Group 4: Control","Patients with normal (\\\u003C 0.015mg\u002FL) high sensitive troponin T (hsTnT) levels without late enhancement, without myocardial infarction and without wall motion abnormalities will serve as control group and will be classified to group 4.",[13,20,14,15],[30,35,39,43],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"PROCEDURE","Short cardiovascular MRI (CMR)","A short CMR without additional contrast administration will be performed immediately after the routine brain MRI (at admission or after 24h).",[9,17,22,26],{"type":31,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Adenosine-perfusion cardiovascular MRI (CMR)","An adenosine-perfusion CMR using contrast medium (gadolinium) will be performed in all patients (except group 1) between 48h and 6 days after admission.",[17,22,26],{"type":31,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"Blood draw","The following study-specific parameters will be tested: neuropeptide Y 1-36, neuropeptide Y 3-36, total plasma metanephrines, metabolomics analysis\n\nTime points for blood draw: at admission (routine), 3h (routine), 24h (routine), 48h, 72h and 3 months.",[9,17,22,26],{"type":31,"name":44,"description":45,"armGroupLabels":46,"otherNames":10},"Urine (collection over 24h)","The following study-specific parameters will be tested: catecholamines.\n\nTime points for collection: at 24h, 72h, and 3 months",[9,17,22,26],[48],{"name":49,"affiliation":50,"role":51},"Simon Jung, PD Dr. med.","Dep. of Neurology, Inselspital Bern","STUDY_DIRECTOR",[53,57],{"name":49,"role":54,"phone":55,"phoneExt":10,"email":56},"CONTACT","+41 31 632 79 56","simon.jung@insel.ch",{"name":58,"role":54,"phone":59,"phoneExt":10,"email":60},"Marianne Kormann","+41 31 632 06 48","marianne.kormann@insel.ch",[62],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Bern University Hospital - Inselspital","RECRUITING","Bern","Canton of Bern","3010","Switzerland","CH",{"type":71,"coordinates":72},"Point",[73,74],7.44744,46.94809,{"lat":74,"lon":73},[77,78],{"name":49,"role":54,"phone":10,"phoneExt":10,"email":56},{"name":49,"role":79,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":81,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100341051","the-bern-heart-and-brain-interaction-study---interaction-between-brain-and-heart-in-acute-ischemic-stroke-100341051",false,"NCT03720522","The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke","BEHABIS","Inclusion Criteria:\n\n* Informed consent as documented by signature.\n* Age: ≥ 18 and \\\u003C 86 years.\n* Acute ischemic stroke with symptom onset within 12 hours before admission to hospital.\n* Diagnosis of acute ischemic stroke with MRI with diffusion restriction as seen on diffusion weighted imaging.\n\nExclusion Criteria:\n\n* Pregnancy. A negative pregnancy test upon admission is required for all women with child-bearing potential.\n* Standard contraindication for performing MRI.\n* Severe renal failure (GFR \\\u003C40).","ALL","18 Years","86 Years",{"count":93,"type":94},220,"ESTIMATED","OBSERVATIONAL","Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.",[98],"Acute Stroke","2024-11-19",{"date":101,"type":102},"2024-11-22","ACTUAL",{"date":104,"type":102},"2018-12-01",{"date":106,"type":94},"2026-12-31",{"name":5,"class":6},1]