[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586938":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":138,"collaborators":10,"id":140,"slug":141,"hasResults":142,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":10,"eligibilityCriteria":146,"healthyVolunteers":142,"sex":147,"minAge":148,"maxAge":10,"enrollmentInfo":149,"targetDuration":10,"studyType":152,"phases":10,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":66,"whyStopped":10,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":172},{"fullName":5,"class":6},"University of Manchester","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Participant",null,"All participants of this study will be undergoing an autologous chondrocyte implantation of the knee for a chondral defect.",[13],"Procedure: Autologous Chondrocyte Implantation (ACI)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Autologous Chondrocyte Implantation (ACI)","ACI is a two-stage process that utilises the patient's own chondrocytes to repair damaged chondral tissue. After a harvesting procedure to obtain the cells, the chondrocytes are cultured and expanded in a specialised laboratory. A second procedure is then performed to implant the cells into the defect to replace and regenerate the injured cartilage. ACI allows the knee to generate durable and hyaline-like repair tissue.",[9],[21],{"name":22,"affiliation":5,"role":23},"Gwenllian F Tawy, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","01617462371","gwenllian.tawy@manchester.ac.uk",[30,50,64,79,96,110,124],{"facility":31,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Royal Orthopaedic Hospital","NOT_YET_RECRUITING","Birmingham","B31 2AP","United Kingdom","UK",{"type":38,"coordinates":39},"Point",[40,41],-1.89983,52.48142,{"lat":41,"lon":40},[44,46,47],{"name":45,"role":26,"phone":10,"phoneExt":10,"email":10},"Martyn Snow, FRCS",{"name":45,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Gwenllian Tawy, PhD","SUB_INVESTIGATOR",{"facility":51,"status":32,"city":52,"state":10,"zip":53,"country":35,"countryCode":36,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Addenbrooke's Hospital","Cambridge","CB2 0QQ",{"type":38,"coordinates":55},[56,57],0.11667,52.2,{"lat":57,"lon":56},[60,62,63],{"name":61,"role":26,"phone":10,"phoneExt":10,"email":10},"Wasim Khan, FRCS",{"name":61,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},{"facility":65,"status":66,"city":67,"state":10,"zip":68,"country":35,"countryCode":36,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Chapel Allerton Orthopaedic Centre","RECRUITING","Leeds","LS7 4SA",{"type":38,"coordinates":70},[71,72],-1.54785,53.79648,{"lat":72,"lon":71},[75,77,78],{"name":76,"role":26,"phone":10,"phoneExt":10,"email":10},"Ram Venkatesh, FRCS",{"name":76,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},{"facility":80,"status":66,"city":81,"state":10,"zip":82,"country":35,"countryCode":36,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Trafford General Hospital","Manchester","M415SL",{"type":38,"coordinates":84},[85,86],-2.23743,53.48095,{"lat":86,"lon":85},[89,90,92,94],{"name":22,"role":26,"phone":10,"phoneExt":10,"email":10},{"name":91,"role":49,"phone":10,"phoneExt":10,"email":10},"Leela Biant",{"name":93,"role":23,"phone":10,"phoneExt":10,"email":10},"Gwenllian Tawy",{"name":95,"role":49,"phone":10,"phoneExt":10,"email":10},"Michael McNicholas",{"facility":97,"status":32,"city":98,"state":10,"zip":99,"country":35,"countryCode":36,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Southampton General Hospital","Southampton","SO16 6YD",{"type":38,"coordinates":101},[102,103],-1.40428,50.90395,{"lat":103,"lon":102},[106,108,109],{"name":107,"role":26,"phone":10,"phoneExt":10,"email":10},"Gorav Datta, FRCS",{"name":107,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},{"facility":111,"status":66,"city":112,"state":10,"zip":113,"country":35,"countryCode":36,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Royal National Orthopaedic Hospital","Stanmore","HA7 4LP",{"type":38,"coordinates":115},[116,117],-0.31667,51.61667,{"lat":117,"lon":116},[120,122,123],{"name":121,"role":26,"phone":10,"phoneExt":10,"email":10},"Chethan Jayadev, FRCS",{"name":121,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},{"facility":125,"status":66,"city":126,"state":10,"zip":127,"country":35,"countryCode":36,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"New Cross Hospital","Wolverhampton","WV10 0QP",{"type":38,"coordinates":129},[130,131],-2.12296,52.58547,{"lat":131,"lon":130},[134,136,137],{"name":135,"role":26,"phone":10,"phoneExt":10,"email":10},"Varun Dewan, FRCS",{"name":135,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},{"type":23,"investigatorFullName":93,"investigatorTitle":139,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dr","100586938","the-biomechanical-outcomes-of-autologous-chondrocyte-implantation-100586938",false,"NCT06921889","The Biomechanical Outcomes of Autologous Chondrocyte Implantation","Investigating the Biomechanical and Functional Outcomes of Autologous Chondrocyte Implantation: A Multi-centre Study","Inclusion Criteria:\n\n* Diagnosis of a chondral injury to the knee by a consultant orthopaedic surgeon Participants must have this diagnosis, else they are not eligible for ACI surgery.\n* Listed for ACI for a chondral injury by a consultant orthopaedic surgeon Participants must be listed for ACI, as this is the treatment of interest in this research study\n* Over 18 years old Participants must be legally capable of providing informed consent for the study.\n\nExclusion Criteria:\n\n* Listed for any treatment other than ACI Participants must be listed for ACI, as this is the treatment of interest in this research study\n* Under 18 years old. Participants must be legally capable of providing informed consent for the study.","ALL","18 Years",{"count":150,"type":151},47,"ESTIMATED","OBSERVATIONAL","Injury to the knee can damage the lining of the knee's bones, called cartilage. Cartilage injuries cause pain and limit movement, making activities like walking, playing sports, and working difficult.\n\nCartilage cannot repair itself well, so surgery is often needed to repair it. People who have cartilage repair surgery want to return to normal activities after their operation. Doctors and scientists know the operation can reduce pain, but do not fully understand how it affects movement.\n\nThis research will help us see if knee function gets better after cartilage repair surgery. The results will help doctors and patients understand what to expect from the surgery. It could also uncover common problems after surgery that could be fixed with physiotherapy.\n\nThis research is important because untreated cartilage injuries can develop into arthritis later in life. Arthritis is a painful lifelong condition that could be prevented by effectively treating the cartilage injury.\n\nIn this study, adult patients who are waiting to have a type of cartilage repair surgery called 'autologous chondrocyte implantation' (ACI) at one of 7 hospitals will be invited to take part in the study by their surgeon. Patients who decide to take part will be invited to two appointments at their own hospital, where assessments of their knee function will be performed. The tests will assess the knee's movement, and the patient's balance and walking abilities. The first research appointment will take place before the operation, and the second and final appointment will take place 6-months after surgery. The results of this study will help us understand how knee function changes after cartilage repair surgery.\n\nThe study will take place across 7 ACI centres in England, and is funded by Orthopaedic Research UK and the British Association for Surgery of the Knee.",[155],"Chondral Defect",[157,158,159,160,161,162],"Chondral defect","Cartilage repair","Knee","Autologous chondrocyte implantation","Biomechanical outcome","Gait","2026-05-01",{"date":165,"type":166},"2026-05-07","ACTUAL",{"date":168,"type":166},"2024-04-22",{"date":170,"type":151},"2026-07-13",{"name":5,"class":6},7]