[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585261":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":136,"collaborators":10,"id":139,"slug":140,"hasResults":141,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":10,"eligibilityCriteria":144,"healthyVolunteers":141,"sex":145,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":10,"studyType":151,"phases":10,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":170},{"fullName":5,"class":6},"Shanghai Pulmonary Hospital, Shanghai, China","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with bronchiectasis",null,"Adult patients diagnosed with bronchiectasis who meet the study's inclusion criteria",[13],{"name":14,"affiliation":5,"role":15},"Yong-hua Gao, Ph.D.","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","+86 17321278520","gaoyonghuahust@163.com",[22,40,54,68,83,93,104,113,122],{"facility":23,"status":24,"city":25,"state":26,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Lin Liu","RECRUITING","Guiyang","Guizhou","China","CN",{"type":30,"coordinates":31},"Point",[32,33],106.71667,26.58333,{"lat":33,"lon":32},[36],{"name":37,"role":18,"phone":38,"phoneExt":10,"email":39},"Lin Liu, MD","+8618685109665","liulin0956@163.com",{"facility":41,"status":24,"city":42,"state":43,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":44,"geoPoint":48,"contacts":49},"Lei Song","Changchun","Jilin",{"type":30,"coordinates":45},[46,47],125.32278,43.88,{"lat":47,"lon":46},[50],{"name":51,"role":18,"phone":52,"phoneExt":10,"email":53},"Lei Song, PhD","+8615948025862","lsong@jlu.edu.cn",{"facility":55,"status":24,"city":56,"state":57,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Qian Qi","Jinan","Shangdong",{"type":30,"coordinates":59},[60,61],116.99722,36.66833,{"lat":61,"lon":60},[64],{"name":65,"role":18,"phone":66,"phoneExt":10,"email":67},"Qian Qi, MD","+8613706380314","qiqianqlh@163.com",{"facility":69,"status":24,"city":70,"state":71,"zip":72,"country":27,"countryCode":28,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"He-feng Chen","Shanghai","Shanghai Municipality","200433",{"type":30,"coordinates":74},[75,76],121.45806,31.22222,{"lat":76,"lon":75},[79],{"name":80,"role":18,"phone":81,"phoneExt":10,"email":82},"He-feng Chen, MD","+8613917472201","13917472201@163.com",{"facility":84,"status":24,"city":70,"state":71,"zip":72,"country":27,"countryCode":28,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},"Zhou-fang Mei",{"type":30,"coordinates":86},[75,76],{"lat":76,"lon":75},[89],{"name":90,"role":18,"phone":91,"phoneExt":10,"email":92},"Zhou-fang Mei, MD","13817546940","meizhoufang8@163.com",{"facility":94,"status":24,"city":70,"state":71,"zip":95,"country":27,"countryCode":28,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Jun She","200437",{"type":30,"coordinates":97},[75,76],{"lat":76,"lon":75},[100],{"name":101,"role":18,"phone":102,"phoneExt":10,"email":103},"Jun She, PhD","+8613641093865","she.jun@zs-hospital.sh.cn",{"facility":105,"status":24,"city":70,"state":71,"zip":95,"country":27,"countryCode":28,"cosmosGeoPoint":106,"geoPoint":108,"contacts":109},"Xue-ling Wu",{"type":30,"coordinates":107},[75,76],{"lat":76,"lon":75},[110],{"name":111,"role":18,"phone":112,"phoneExt":10,"email":10},"Xue-ling Wu, MD","+8618321035326",{"facility":114,"status":24,"city":70,"state":71,"zip":95,"country":27,"countryCode":28,"cosmosGeoPoint":115,"geoPoint":117,"contacts":118},"Yong-hua Gao",{"type":30,"coordinates":116},[75,76],{"lat":76,"lon":75},[119],{"name":120,"role":18,"phone":121,"phoneExt":10,"email":20},"Yong-hua Gao, PhD","+8617321278520",{"facility":123,"status":24,"city":124,"state":125,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Xiao-long Ma","Jiaxing","Zhejiang",{"type":30,"coordinates":127},[128,129],120.75,30.7522,{"lat":129,"lon":128},[132],{"name":133,"role":18,"phone":134,"phoneExt":10,"email":135},"Xiao-long Ma, MD","+8618805839188","maxiaolong801005@sina.com",{"type":15,"investigatorFullName":137,"investigatorTitle":138,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Gao Yong-hua","Associate Professor","100585261","the-c-bridge-study-china-bronchiectasis-research-involving-databases-genomics-and-endotyping-100585261",false,"NCT06900062","The C-BRIDGE Study: China Bronchiectasis Research Involving Databases, Genomics, and Endotyping","Inclusion Criteria:\n\n* A prior CT scan confirming bronchiectasis, accompanied by a compatible clinical syndrome including cough, sputum production, and\u002For recurrent respiratory tract infections.\n* At the screening visit, participants must have been clinically stable for 4 weeks, defined as no antibiotic or corticosteroid treatment for a pulmonary exacerbation in the preceding 4 weeks.\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Age under 18 years\n* Patients with active tuberculosis\n* Use of antibiotics or corticosteroids for a pulmonary exacerbation within the past 4 weeks","ALL","18 Years","85 Years",{"count":149,"type":150},1500,"ESTIMATED","OBSERVATIONAL","Bronchiectasis is a heterogeneous airway disease with diverse causes, making precise diagnosis, prognosis, and treatment response prediction challenging. Identifying patient subgroups (phenotypes) and molecular profiles (endotypes) can enhance individualized assessment and management. While prior studies, primarily in European populations, have identified key phenotypes and endotypes, their relevance to Chinese patients remains unclear due to geographic and clinical differences. Specific causes of bronchiectasis, such as allergic bronchopulmonary aspergillosis (ABPA) and primary ciliary dyskinesia (PCD), may also exhibit distinct pathophysiology requiring further exploration. The C-BRIDGE Study seeks to characterize phenotypes and endotypes in Chinese bronchiectasis patients during stable disease and exacerbations, evaluate differences in clinical outcomes across these subgroups, and develop personalized medicine strategies based on these findings, applicable in China and globally.\n\nPrimary Objective: To identify molecular endotypes of bronchiectasis that accurately predict prognosis and guide treatment responses.\n\nSecondary Objectives:\n\nTo characterize molecular endotypes of stable bronchiectasis in Chinese patients.\n\nTo define molecular endotypes of bronchiectasis exacerbations in Chinese patients.\n\nTo investigate molecular endotypes specific to allergic bronchopulmonary aspergillosis (ABPA).\n\nTo explore genotypes and inflammatory endotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) in Chinese patients.\n\nTo validate candidate biomarkers for stable and exacerbation endotypes to support stratified medicine.\n\nTo conduct in vivo or in vitro proof-of-concept studies using phenotypic data to identify patient subgroups likely to benefit from specific pharmacological interventions.\n\nStudy Design: This observational cohort study will link identified patient subgroups with meaningful clinical outcomes to inform prognosis and optimize treatment strategies.",[154],"Bronchiectasis Adult",[156,157,158,159,160],"bronchiectasis","phenotype","endotype","multi-omics","precision medicine","2025-11-19",{"date":163,"type":164},"2025-11-25","ACTUAL",{"date":166,"type":164},"2025-04-06",{"date":168,"type":150},"2029-01-31",{"name":5,"class":6},9]