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We will be enrolling e-cigarette-only users, non-e-cigarette and non-combustible cigarette users, combustible cigarette-only users, and dual combustible cigarette-e-cigarette users.",{"label":13,"type":10,"description":14,"interventionNames":10},"Adolescents","Canadian adolescents aged between 12 and \\\u003C19 years, inclusive. We will be enrolling e-cigarette-only users, as well as non-e-cigarette and non-combustible cigarette users.",[16],{"name":17,"affiliation":5,"role":18},"Janice Leung, MD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","604-836-0423","janice.leung@hli.ubc.ca",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Paloma Burns, MSc","604-442-7021","pburns@providencehealth.bc.ca",[29,55,74,90,108,130,149,171],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University of Alberta (Clinical Sciences Building)","RECRUITING","Edmonton","Alberta","T6G 2B7","Canada","CA",{"type":38,"coordinates":39},"Point",[40,41],-113.46871,53.55014,{"lat":41,"lon":40},[44,48,51,53],{"name":45,"role":21,"phone":46,"phoneExt":10,"email":47},"Michael Stickland","(780) 492-1657","mks2@ualberta.ca",{"name":49,"role":21,"phone":10,"phoneExt":10,"email":50},"Desi 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Counil",{"type":18,"investigatorFullName":98,"investigatorTitle":192,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Assistant Professor, Department of Medicine, University of British Columbia, Principal Investigator, Centre for Heart Lung Innovation, St. Paul's Hospital, Respirologist, St. Paul's Hospital",[194,195,197,199,201,203,205,206],{"name":75,"class":6},{"name":196,"class":6},"Providence Healthcare",{"name":198,"class":6},"British Columbia Cancer Agency",{"name":200,"class":6},"University of Alberta",{"name":202,"class":6},"McMaster University",{"name":204,"class":6},"University of Ottawa",{"name":172,"class":6},{"name":207,"class":6},"University of Toronto","100579105","the-canadian-lung-outcomes-in-users-of-vaping-devices-study-100579105",false,"NCT06819969","The Canadian Lung Outcomes in Users of Vaping Devices Study","The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study","CLOUD","Inclusion Criteria:\n\nAdolescent arm:\n\n* Aged ≥12 and \\\u003C19 years old\n* Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively\n\nAdult arm:\n\n* Aged ≥19 years old\n* Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently\n\nExclusion Criteria:\n\nAdolescent arm:\n\n* Contraindication to pulmonary function testing and cardiopulmonary exercise testing\n* Have smoked combustible cannabis within the last month and\u002For have a combustible cannabis smoking history of \\>1 joint-year\n* Have smoked combustible cigarettes within the last 6 months\n* Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia)\n* Inability to provide written informed consent\n\nAdult arm:\n\n* Contraindication to pulmonary function testing and cardiopulmonary exercise testing\n* Have smoked combustible cannabis within the last month and\u002For have a combustible cannabis smoking history of \\>1 joint-year\n* Currently undergoing treatment for lung cancer\n* Inability to provide written informed consent\n\nNo limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.",true,"ALL","12 Years",{"count":220,"type":221},500,"ESTIMATED","OBSERVATIONAL","Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient and propose new ways to find lung injuries that may impact them over the course of their lives. These include exercise testing, new imaging techniques, and new breathing tests that will demonstrate how vaping may harm their lungs. We will use these tools in both adolescent and adult Canadians to give Canadians who vape important information on the consequences of vaping.",[225,226,227,228,229],"Small Airways Diseases","Vaping","Vaping Related Disorder","Vaping Teens","Vaping Behavior",[214,231,232,233,234,235,236,237,238,239,240,241,242,243,244],"small airway injury","vaping","vape","e-cigarette","oscillometry","multiple breath washout","chest computed tomography","chest CT","hyperpolarized 129-xenon","MRI","CPET","bronchoscopy","transcriptomics","epigenetics","2026-03-24",{"date":247,"type":248},"2026-03-30","ACTUAL",{"date":250,"type":248},"2025-07-25",{"date":252,"type":221},"2029-12-31",{"name":5,"class":6},8]