[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100357259":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":31,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":10,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Children's Hospital of Fudan University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Sick Neonatal Cohort, Sequencing",null,"Infants and their parents enrolled through Neonatal Intensive Care Unit of member hospitals who are un-randomized to receive genomic sequencing. Results disclosure sessions will include a discussion of: family history report, results from standard newborn screening, any potentially medically relevant findings from the baby's medical history\u002Fphysical exam, and the results of the genomic sequencing report.",[13],"Genetic: Genomic sequencing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"GENETIC","Genomic sequencing","Both sick and high-risk newborn un-randomized to receive genomic sequencing will receive a Genomic Newborn Sequencing Report which will include pathogenic or likely pathogenic variants identified in genes associated with childhood-onset disease.",[9],[21],{"name":22,"affiliation":5,"role":23},"Wenhao Zhou","STUDY_CHAIR",[25,28],{"name":22,"role":26,"phone":10,"phoneExt":10,"email":27},"CONTACT","zwhchfu@126.com",{"name":29,"role":26,"phone":10,"phoneExt":10,"email":30},"Lin Yang","yanglin_fudan@163.com",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Children Hospital of Fudan University","RECRUITING","Shanghai","Shanghai Municipality","201102","China","CN",{"type":41,"coordinates":42},"Point",[43,44],121.45806,31.22222,{"lat":44,"lon":43},[47],{"name":48,"role":26,"phone":49,"phoneExt":10,"email":27},"Wenhao Zhou, Doctor","(+86)021-64931003",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100357259","the-china-neonatal-genomes-project-100357259",false,"NCT03931707","The China Neonatal Genomes Project","CNGP","Inclusion Criteria:\n\n* 1\\. Both parents are of Chinese origin;\n* 2\\. Postnatal age less than 28 days;\n* 3\\. Can be retained to at least 1ml venous blood sample;\n* 4\\. Biological parent or guardian's informed consent.\n\nExclusion Criteria:\n\n* 1\\. the nationality of one of the parents is not the Han nationality or other national minorities;\n* 2\\. reluctance of parents to use genetic sequencing data for subsequent research;\n* 3\\. parents under 18 years of age or incapacitated for decision-making;\n* 4\\. subjects older than 28 days.\n* 5\\. multiple pregnancies;\n* 6\\. lack of access to biological samples from which DNA can be extracted;\n* 7\\. failure to sign informed consent",true,"ALL","28 Days",{"count":63,"type":64},100000,"ESTIMATED","OBSERVATIONAL","The project will carry out the genetic testing of 100000 neonates in the next 5 years. The aim of the project is to construct the Chinese neonatal genome database, establish the genetic testing standard of neonatal genetic diseases, and promote the industrialization of neonatal genetic disease gene testing, improve the training system for genetic counseling.",[68,69,70,71],"Newborn","Hereditary Disease","Genetic Predisposition to Disease","Defect, Congenital",[68,69,70,71,73,74,75,76],"Genome Sequencing","Exome Sequencing","Newborn Screening","Genetic Diseases, Inborn","2026-03-13",{"date":79,"type":80},"2026-03-16","ACTUAL",{"date":82,"type":80},"2016-08-08",{"date":84,"type":64},"2026-12-30",{"name":5,"class":6},1]