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Hospital","Zigong",{"type":34,"coordinates":630},[631,632],104.77689,29.34162,{"lat":632,"lon":631},[635],{"name":636,"role":22,"phone":10,"phoneExt":10,"email":637},"Xiaoya Xu, Doctor","502687651@qq.com",{"facility":639,"status":28,"city":640,"state":641,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":642,"geoPoint":646,"contacts":647},"Tianjin Huanhu Hospital","Xianshuigu","Tianjin Municipality",{"type":34,"coordinates":643},[644,645],117.38278,38.985,{"lat":645,"lon":644},[648],{"name":649,"role":22,"phone":10,"phoneExt":10,"email":650},"Yuying Zhou, Doctor","Qiying789@sina.cn",{"facility":652,"status":28,"city":653,"state":641,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":654,"geoPoint":658,"contacts":659},"Tianjin Medical University General Hospital","Xiaobailou",{"type":34,"coordinates":655},[656,657],117.20565,39.11766,{"lat":657,"lon":656},[660],{"name":661,"role":22,"phone":10,"phoneExt":10,"email":662},"Nan Zhang, Doctor","nkzhangnan@163.com",{"facility":664,"status":28,"city":665,"state":666,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":667,"geoPoint":671,"contacts":672},"Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region","Ürümqi","Xinjiang",{"type":34,"coordinates":668},[669,670],87.60046,43.80096,{"lat":670,"lon":669},[673],{"name":674,"role":22,"phone":10,"phoneExt":10,"email":675},"Xinling Meng","altmxl@126.com",{"facility":677,"status":28,"city":678,"state":679,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":680,"geoPoint":684,"contacts":685},"First Affiliated Hospital of Zhejiang University","Hangzhou","Zhejiang",{"type":34,"coordinates":681},[682,683],120.16142,30.29365,{"lat":683,"lon":682},[686],{"name":687,"role":22,"phone":10,"phoneExt":10,"email":688},"Benyan Luo, Doctor","luobenyan@zju.edu.cn",{"facility":690,"status":28,"city":678,"state":679,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":691,"geoPoint":693,"contacts":694},"Shao Yifu Hospital of Zhejiang Medical University",{"type":34,"coordinates":692},[682,683],{"lat":683,"lon":682},[695],{"name":696,"role":22,"phone":10,"phoneExt":10,"email":697},"Peilin Lu, Doctor","lplzxa@163.com",{"facility":699,"status":28,"city":678,"state":679,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":700,"geoPoint":702,"contacts":703},"Zhejiang Provincial People's Hospital",{"type":34,"coordinates":701},[682,683],{"lat":683,"lon":682},[704],{"name":705,"role":22,"phone":10,"phoneExt":10,"email":706},"Enyan Yu","yuenyan@aliyun.com",{"facility":708,"status":28,"city":709,"state":679,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":710,"geoPoint":714,"contacts":715},"Ningbo City Medical Treatment Center Lihuili Hospital","Ningbo",{"type":34,"coordinates":711},[712,713],121.54945,29.87819,{"lat":713,"lon":712},[716],{"name":717,"role":22,"phone":10,"phoneExt":10,"email":718},"Guomin Xie, Doctor","drxie01@qq.com",{"facility":720,"status":28,"city":721,"state":679,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":722,"geoPoint":726,"contacts":727},"First Affiliated Hospital of Wenzhou Medical Univeristy","Wenzhou",{"type":34,"coordinates":723},[724,725],120.66682,27.99942,{"lat":725,"lon":724},[728],{"name":729,"role":22,"phone":10,"phoneExt":10,"email":730},"Zhen Wang","Jane.wz@163.com",{"type":732,"investigatorFullName":733,"investigatorTitle":734,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jianping Jia","Chief Director",[736,738,739,740,741,742,743,744,745,746,747,748,750,751,752,753,754,755,756,757,758,759,761,762,763,765,767,768,769,770,772,773,774,775,777,779,781,782,783,784,785,786,788,789,790,791,793,794,795,796,797,798,799,800,801,802,803,805,807,808,809,810,811,812,813,815,817],{"name":737,"class":6},"Beijing Tiantan Hospital",{"name":57,"class":6},{"name":94,"class":6},{"name":112,"class":6},{"name":119,"class":6},{"name":103,"class":6},{"name":82,"class":6},{"name":64,"class":6},{"name":44,"class":6},{"name":425,"class":6},{"name":141,"class":6},{"name":149,"class":749},"OTHER_GOV",{"name":161,"class":6},{"name":173,"class":6},{"name":186,"class":6},{"name":199,"class":6},{"name":236,"class":6},{"name":212,"class":6},{"name":224,"class":6},{"name":269,"class":6},{"name":256,"class":6},{"name":760,"class":6},"People's Hospital of Zhengzhou University",{"name":248,"class":6},{"name":305,"class":6},{"name":292,"class":764},"UNKNOWN",{"name":766,"class":6},"Zhongnan Hospital",{"name":314,"class":6},{"name":327,"class":6},{"name":391,"class":6},{"name":771,"class":6},"China-Japan Union Hospital, Jilin University",{"name":346,"class":764},{"name":333,"class":764},{"name":353,"class":764},{"name":776,"class":6},"Jiangxi Provincial People's Hopital",{"name":778,"class":6},"Anshan Central Hospital",{"name":780,"class":6},"Affiliated Zhongshan Hospital of Dalian University",{"name":434,"class":6},{"name":446,"class":6},{"name":459,"class":6},{"name":472,"class":6},{"name":527,"class":6},{"name":787,"class":764},"The 960th Hospital of PLA",{"name":481,"class":6},{"name":506,"class":6},{"name":494,"class":749},{"name":792,"class":6},"Qingdao Municipal Hospital",{"name":580,"class":6},{"name":605,"class":6},{"name":593,"class":6},{"name":561,"class":6},{"name":573,"class":6},{"name":548,"class":6},{"name":614,"class":6},{"name":639,"class":6},{"name":652,"class":6},{"name":664,"class":764},{"name":804,"class":749},"Ningbo Medical Center Lihuili Hospital",{"name":806,"class":6},"First Affiliated Hospital of Wenzhou Medical University",{"name":677,"class":6},{"name":690,"class":764},{"name":699,"class":6},{"name":125,"class":6},{"name":135,"class":6},{"name":27,"class":6},{"name":814,"class":6},"People's Hospital of Chongqing",{"name":816,"class":6},"Dongfang Hospital Beijing University of Chinese Medicine",{"name":818,"class":6},"Zigong No.1 Peoples Hospital","100336231","the-chinese-familial-alzheimers-network-100336231",false,"NCT03657732","The Chinese Familial Alzheimer's Network","A Multi-center Longitudinal Cohort Study of Familial Alzheimer's Disease in China","CFAN","Familial Alzheimer's disease group\n\nInclusion criteria:\n\n1. Written informed consent obtained from the participant or a legal guardian prior to any study-related procedures;\n2. At least two first-degree relatives in a family have AD (clinically or by testing)，and at least 3 out of 2 generations are patients;\n3. At least one family member with normal cognitive function (the age should be greater than the average age of onset of the family);\n4. Pedigrees carrying FAD pathogenic genes (APP\u002FPSEN1\u002FPSEN2);\n5. People in this family \\>18 years old can be recruited;\n6. Participant is cognitively normal or demented but not reaching bedridden level;\n7. Participants are able to provide two reliable informants who can provide clinical information;\n8. Dementia is diagnosed according to the criteria described by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-R );\n9. The diagnosis of AD is made using the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA ) or National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria ;\n10. The diagnosis of MCI is made according to Petersen criteria and the classification is according to the method of Lopez et al.\n\nExclusion criteria:\n\n1. Dementia caused by other factors such as depression, other psychiatric illnesses, thyroid dysfunction, encephalitis, multiple sclerosis, brain trauma, brain tumor, syphilis, acquired immunodeficiency syndrome (AIDS), Creutzfeldt-Jakob disease and other types of dementias such as vascular dementia (VaD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson's dementia (PDD)；\n2. MRI and laboratory tests do not support or rule out a diagnosis of AD；\n3. Severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina, uncontrollable asthma, active gastric bleeding) and cancer；\n4. Participant has severe psychiatric illness or severe dementia that would interfere in completing initial and follow-up clinical assessments；\n5. Participant has a history of alcoholism or drug abuse；\n6. Pregnant or lactating women；\n7. No reliable informant；\n8. Lumbar puncture exclusion criteria：coagulation disorders or platelet counts \\\u003C 100,000 cells\u002FμL, lumbar surgery within the last 6 months prior to lumbar puncture that interferes with anatomy of the inter-vertebral spaces, History of chronic or repeated CSF leakage following previous LP(s);\n9. MRI Exclusion Criteria: electronic and magnetic metal implants such as pacemakers, artificial heart valve, metal prosthesis, metal joint, etc.; metallic foreign body in the eye; aneurysm clips in the brain.\n\nNormal control group\n\nInclusion criteria:\n\n1. Aged 18 (inclusive) or above;\n2. Normal MMSE and MoCA evaluations. MMSE\\>19 points for illiteracy, \\>24 points for those educated less than 7 years, \\>27 points for those educated equal to or more than 7 years. MoCA\\>13 points for illiteracy, \\>19 points for those educated less than 7 years, \\>24 points for those educated equal to or more than 7 years.\n\nExclusion criteria:\n\n1. Subjects with abnormal MMSE or MoCA scores;\n2. Subjects with a history of cerebral infarction, traumatic brain injury or related manifestations in MRI;\n3. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);\n4. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);\n5. Mental and neurodevelopmental retardation;\n6. Suffering from a disease that cannot be combined with a cognitive examination;\n7. Contraindications to MRI;\n8. Refuse to draw blood;\n9. Refuse to sign the informed consent at baseline.",true,"ALL","18 Years",{"count":831,"type":832},40000,"ESTIMATED","30 Years","OBSERVATIONAL","This research will establish and continuously improve the FAD research network in conjunction with multi-center institutions nationwide. By collecting information on the family's demography, genetics, neuropsychology, neuroimaging, biomarkers and other information, we can understand the current FAD population in China, clarify the genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of AD in China; which will lay the foundation for ameliorating clinical diagnosis and treatment, establishing a Chinese FAD clinical database and an international cooperative research platform.\n\n1. To set up a multi-center, nationwide FAD research network and database platform in China\n2. To clarify the epidemiological characteristics of FAD in China.\n3. To clarify the genetic characteristics of FAD in China.\n4. To clarify the clinical characteristics and disease development laws of FAD.\n5. To discover and verify the early diagnosis biomarkers of AD.\n6. To establish a genetic counseling model.",[837,838],"Alzheimer Disease","Familial Alzheimer Disease (FAD)",[840],"Alzheimer's Disease","2026-03-19",{"date":843,"type":844},"2026-03-23","ACTUAL",{"date":846,"type":844},"2005-01-10",{"date":848,"type":832},"2038-01-01",{"name":5,"class":6},65]