[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472196":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":469,"collaborators":24,"id":471,"slug":472,"hasResults":473,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":473,"sex":479,"minAge":480,"maxAge":24,"enrollmentInfo":481,"targetDuration":24,"studyType":484,"phases":485,"briefSummary":487,"conditions":488,"keywords":24,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":499,"locationsCount":500},{"fullName":5,"class":6},"Maastricht University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Portal Vein Embolization (PVE) alone - (control arm)","ACTIVE_COMPARATOR","Portal Vein Embolization (PVE) alone",[13],"Procedure: Embolization",{"label":15,"type":16,"description":15,"interventionNames":17},"Combined Portal and Hepatic Vein Embolization (PVE\u002FHVE) - (interventional arm)","EXPERIMENTAL",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Embolization","Portal Vein embolization with Glue by a transhepatic approach vs. PVE and Hepatic Vein Occlusion with Vascular plugs via a transjugular or transfemoral approach in the same session as the PVE procedure",[15,9],null,[26],{"name":27,"affiliation":28,"role":29},"Ronald M. van Dam, PhD","Maastricht Universitair Medisch Centrum","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Sinéad James, MD, PhD-candidate","CONTACT","+31 638463945","sinead.james@mumc.nl",{"name":37,"role":33,"phone":38,"phoneExt":24,"email":39},"Jens Smits","+31640725518","jens.smits@mumc.nl",[41,60,75,99,118,136,155,172,189,202,218,230,245,270,298,313,334,351,364,379,396,416,430,453],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Yale New Haven Hospital","RECRUITING","New Haven","Connecticut","06510","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-72.92816,41.30815,{"lat":53,"lon":52},[56,58],{"name":57,"role":33,"phone":24,"phoneExt":24,"email":24},"Kevin Billingsley",{"name":59,"role":33,"phone":24,"phoneExt":24,"email":24},"David Madoff",{"facility":61,"status":43,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Monash Medical Centre","Clayton","Victoria","3168","Australia","AU",{"type":50,"coordinates":68},[69,70],145.11667,-37.91667,{"lat":70,"lon":69},[73],{"name":74,"role":33,"phone":24,"phoneExt":24,"email":24},"Diederick De Boo, PhD",{"facility":76,"status":77,"city":78,"state":79,"zip":80,"country":81,"countryCode":82,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Social Medical Center, South","NOT_YET_RECRUITING","Vienna","State of Vienna","1100","Austria","AT",{"type":50,"coordinates":84},[85,86],16.37208,48.20849,{"lat":86,"lon":85},[89,91,93,95,97],{"name":90,"role":33,"phone":24,"phoneExt":24,"email":24},"Thomas Gruenberger, MD",{"name":92,"role":33,"phone":24,"phoneExt":24,"email":24},"Tanja Friz, BSc",{"name":94,"role":33,"phone":24,"phoneExt":24,"email":24},"Tony Padickakudy",{"name":96,"role":33,"phone":24,"phoneExt":24,"email":24},"Tanja Fritz",{"name":98,"role":33,"phone":24,"phoneExt":24,"email":24},"Ivan Baclija",{"facility":100,"status":43,"city":101,"state":102,"zip":103,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Hôpital Erasme","Brussels","Brussels Capital","1070","Belgium","BE",{"type":50,"coordinates":107},[108,109],4.34878,50.85045,{"lat":109,"lon":108},[112,114,116],{"name":113,"role":33,"phone":24,"phoneExt":24,"email":24},"Valerio Lucidi, MD PhD",{"name":115,"role":33,"phone":24,"phoneExt":24,"email":24},"Viviane van Laethem",{"name":117,"role":33,"phone":24,"phoneExt":24,"email":24},"Illario Tancredi, MD PhD",{"facility":119,"status":43,"city":120,"state":120,"zip":121,"country":104,"countryCode":105,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"CHU de Liège","Liège","4000",{"type":50,"coordinates":123},[124,125],5.56749,50.63373,{"lat":125,"lon":124},[128,130,132,134],{"name":129,"role":33,"phone":24,"phoneExt":24,"email":24},"Celine Lambrecht",{"name":131,"role":33,"phone":24,"phoneExt":24,"email":24},"Olivier Detry",{"name":133,"role":33,"phone":24,"phoneExt":24,"email":24},"Olivier Detry, MD PhD",{"name":135,"role":33,"phone":24,"phoneExt":24,"email":24},"Laurent Gérard, MD PhD",{"facility":137,"status":43,"city":138,"state":139,"zip":140,"country":104,"countryCode":105,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"CHU-UCL Namur site Godinne","Yvoir","Namen","5530",{"type":50,"coordinates":142},[143,144],4.88059,50.3279,{"lat":144,"lon":143},[147,149,151,153],{"name":148,"role":33,"phone":24,"phoneExt":24,"email":24},"Aelxandra Dili, MD PhD",{"name":150,"role":33,"phone":24,"phoneExt":24,"email":24},"Claude Bertrand, MD PhD",{"name":152,"role":33,"phone":24,"phoneExt":24,"email":24},"Alexandra Dili, MD PhD",{"name":154,"role":33,"phone":24,"phoneExt":24,"email":24},"Jean- François De Wispelaere, MD PhD",{"facility":156,"status":43,"city":157,"state":158,"zip":159,"country":104,"countryCode":105,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"UZ Gent","Ghent","Oost-Vlaanderen","Gent (9000)",{"type":50,"coordinates":161},[162,163],3.71667,51.05,{"lat":163,"lon":162},[166,168,170],{"name":167,"role":33,"phone":24,"phoneExt":24,"email":24},"Luis Luis Abreu de Carvalho",{"name":169,"role":33,"phone":24,"phoneExt":24,"email":24},"Luis Abreu de Carvalho",{"name":171,"role":33,"phone":24,"phoneExt":24,"email":24},"Laurens Hermie",{"facility":173,"status":43,"city":174,"state":175,"zip":176,"country":177,"countryCode":178,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"Vancouver Coastal Health","Vancouver","British Columbia","V5Z 4H5","Canada","CA",{"type":50,"coordinates":180},[181,182],-123.11934,49.24966,{"lat":182,"lon":181},[185,187],{"name":186,"role":33,"phone":24,"phoneExt":24,"email":24},"Maja Segedi",{"name":188,"role":33,"phone":24,"phoneExt":24,"email":24},"Maya Segedi",{"facility":190,"status":43,"city":191,"state":192,"zip":193,"country":177,"countryCode":178,"cosmosGeoPoint":194,"geoPoint":198,"contacts":199},"Juravinski Hospital and Cancer Centre","Hamilton","Ontario","ON L8V 5C2",{"type":50,"coordinates":195},[196,197],-79.84963,43.25011,{"lat":197,"lon":196},[200],{"name":201,"role":33,"phone":24,"phoneExt":24,"email":24},"Leyo Ruo",{"facility":203,"status":43,"city":204,"state":192,"zip":205,"country":177,"countryCode":178,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"The Ottawa Hospital","Ottawa","k1H 8L6",{"type":50,"coordinates":207},[208,209],-75.69812,45.41117,{"lat":209,"lon":208},[212,214,216],{"name":213,"role":33,"phone":24,"phoneExt":24,"email":24},"Guillaume Martel, MD",{"name":215,"role":33,"phone":24,"phoneExt":24,"email":24},"Stephen Ryan, MD, PhD",{"name":217,"role":33,"phone":24,"phoneExt":24,"email":24},"Aklile Workneh",{"facility":219,"status":43,"city":220,"state":192,"zip":221,"country":177,"countryCode":178,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Sunnybrook Hospital","Toronto","M4N 3M5",{"type":50,"coordinates":223},[224,225],-79.39864,43.70643,{"lat":225,"lon":224},[228],{"name":229,"role":33,"phone":24,"phoneExt":24,"email":24},"Paul Karanicolas",{"facility":231,"status":77,"city":232,"state":24,"zip":24,"country":177,"countryCode":178,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"McGill University Health Center","Montreal",{"type":50,"coordinates":234},[235,236],-73.58781,45.50884,{"lat":236,"lon":235},[239,241,243],{"name":240,"role":33,"phone":24,"phoneExt":24,"email":24},"Jeniffer Kalil",{"name":242,"role":33,"phone":24,"phoneExt":24,"email":24},"Peter Metrakos, Prof",{"name":244,"role":33,"phone":24,"phoneExt":24,"email":24},"David Valenti, Md PhD",{"facility":246,"status":43,"city":247,"state":24,"zip":24,"country":248,"countryCode":249,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"IRCCS San Raffaele Hospital","Milan","Italy","IT",{"type":50,"coordinates":251},[252,253],9.18951,45.46427,{"lat":253,"lon":252},[256,258,260,262,264,266,268],{"name":257,"role":33,"phone":24,"phoneExt":24,"email":24},"Luca Aldrighetti, Prof",{"name":259,"role":33,"phone":24,"phoneExt":24,"email":24},"Stephanie Steidler",{"name":261,"role":33,"phone":24,"phoneExt":24,"email":24},"Luca Aldrighetti, Prof.",{"name":263,"role":33,"phone":24,"phoneExt":24,"email":24},"Francesco De Cobelli, Prof.",{"name":265,"role":33,"phone":24,"phoneExt":24,"email":24},"Francesca Ratti, Dr.",{"name":267,"role":33,"phone":24,"phoneExt":24,"email":24},"Simone Gusmini, Dr.",{"name":269,"role":33,"phone":24,"phoneExt":24,"email":24},"Salvatore Lamarca, Dr.",{"facility":271,"status":43,"city":272,"state":273,"zip":274,"country":275,"countryCode":276,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Maastricht University Medical Center+","Maastricht","Limburg","6229 HX","Netherlands","NL",{"type":50,"coordinates":278},[279,280],5.68889,50.84833,{"lat":280,"lon":279},[283,287,290,291,293,295,296],{"name":284,"role":33,"phone":285,"phoneExt":24,"email":286},"Remon Korenblik, MD","+31637297507","remon.korenblik@mumc.nl",{"name":288,"role":33,"phone":24,"phoneExt":24,"email":289},"Ronald M van Dam, MD, PhD","r.van.dam@mumc.nl",{"name":288,"role":33,"phone":24,"phoneExt":24,"email":24},{"name":292,"role":33,"phone":24,"phoneExt":24,"email":24},"Marc HA Bemelmans, MD, PhD",{"name":294,"role":33,"phone":24,"phoneExt":24,"email":24},"Christiaan van der Leij, MD, PhD",{"name":284,"role":33,"phone":24,"phoneExt":24,"email":24},{"name":297,"role":33,"phone":24,"phoneExt":24,"email":24},"Bram Olij, BCs",{"facility":299,"status":43,"city":300,"state":301,"zip":302,"country":275,"countryCode":276,"cosmosGeoPoint":303,"geoPoint":307,"contacts":308},"Amsterdam UMC, location AMC","Amsterdam","North Holland","1105 AZ",{"type":50,"coordinates":304},[305,306],4.88969,52.37403,{"lat":306,"lon":305},[309,311],{"name":310,"role":33,"phone":24,"phoneExt":24,"email":24},"Joris I Erdmann, MD PhD",{"name":312,"role":33,"phone":24,"phoneExt":24,"email":24},"Otto M van Delden, MD PhD",{"facility":314,"status":43,"city":315,"state":316,"zip":317,"country":275,"countryCode":276,"cosmosGeoPoint":318,"geoPoint":322,"contacts":323},"University Medical Center Groningen","Groningen","Provincie Groningen","9713 GZ",{"type":50,"coordinates":319},[320,321],6.56667,53.21917,{"lat":321,"lon":320},[324,326,328,330,332],{"name":325,"role":33,"phone":24,"phoneExt":24,"email":24},"Marieke T de Boer, MD PhD",{"name":327,"role":33,"phone":24,"phoneExt":24,"email":24},"Jan T Bottema",{"name":329,"role":33,"phone":24,"phoneExt":24,"email":24},"Koert P de Jong",{"name":331,"role":33,"phone":24,"phoneExt":24,"email":24},"Reinhoud PH Bokkers",{"name":333,"role":33,"phone":24,"phoneExt":24,"email":24},"Leanne van der Plas - Kemper",{"facility":335,"status":77,"city":336,"state":337,"zip":338,"country":275,"countryCode":276,"cosmosGeoPoint":339,"geoPoint":343,"contacts":344},"Erasmus Medical Center","Rotterdam","South Holland","3015",{"type":50,"coordinates":340},[341,342],4.47917,51.9225,{"lat":342,"lon":341},[345,347,349],{"name":346,"role":33,"phone":24,"phoneExt":24,"email":24},"Dirk J. Grünhagen, MD PhD",{"name":348,"role":33,"phone":24,"phoneExt":24,"email":24},"Adriaan Moelker, MD PhD",{"name":350,"role":33,"phone":24,"phoneExt":24,"email":24},"Drik J Grünhagen, MD PhD",{"facility":352,"status":77,"city":353,"state":24,"zip":24,"country":275,"countryCode":276,"cosmosGeoPoint":354,"geoPoint":358,"contacts":359},"Amphia","Breda",{"type":50,"coordinates":355},[356,357],4.77596,51.58656,{"lat":357,"lon":356},[360,362],{"name":361,"role":33,"phone":24,"phoneExt":24,"email":24},"Farshad Imani, MD PhD",{"name":363,"role":33,"phone":24,"phoneExt":24,"email":24},"Paul Gobardhan, MD PhD",{"facility":365,"status":43,"city":366,"state":24,"zip":24,"country":275,"countryCode":276,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"Maxima Medisch Centrum","Eindhoven",{"type":50,"coordinates":368},[369,370],5.47778,51.44083,{"lat":370,"lon":369},[373,375,377],{"name":374,"role":33,"phone":24,"phoneExt":24,"email":24},"Wouter Leclercq, MD PhD",{"name":376,"role":33,"phone":24,"phoneExt":24,"email":24},"Wouter KG Leqlercq, MD PhD",{"name":378,"role":33,"phone":24,"phoneExt":24,"email":24},"Laurens van Baardewijk, MD PhD",{"facility":380,"status":43,"city":381,"state":24,"zip":24,"country":275,"countryCode":276,"cosmosGeoPoint":382,"geoPoint":386,"contacts":387},"Universitair Medisch Centrum Utrecht","Utrecht",{"type":50,"coordinates":383},[384,385],5.12222,52.09083,{"lat":385,"lon":384},[388,390,392,394],{"name":389,"role":33,"phone":24,"phoneExt":24,"email":24},"Maarten LJ Smits, MD PhD",{"name":391,"role":33,"phone":24,"phoneExt":24,"email":24},"Jeroen Hagendoorn, MD PhD",{"name":393,"role":33,"phone":24,"phoneExt":24,"email":24},"Inne HM Borel Rinkes, Prof.",{"name":395,"role":33,"phone":24,"phoneExt":24,"email":24},"Rutger CG Bruijnen, MD PhD",{"facility":397,"status":43,"city":398,"state":24,"zip":399,"country":400,"countryCode":401,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"Linköping University Hospital","Linköping","581 85","Sweden","SE",{"type":50,"coordinates":403},[404,405],15.62157,58.41086,{"lat":405,"lon":404},[408,410,412,414],{"name":409,"role":33,"phone":24,"phoneExt":24,"email":24},"Per Sandström, Prof.",{"name":411,"role":33,"phone":24,"phoneExt":24,"email":24},"Bergthor Bjornsson, MD",{"name":413,"role":33,"phone":24,"phoneExt":24,"email":24},"Margareta Ahle, MD",{"name":415,"role":33,"phone":24,"phoneExt":24,"email":24},"Anna Lindhoff Larsson",{"facility":417,"status":43,"city":418,"state":24,"zip":419,"country":400,"countryCode":401,"cosmosGeoPoint":420,"geoPoint":424,"contacts":425},"Karolinska University Hospital","Stockholm","14186",{"type":50,"coordinates":421},[422,423],18.06871,59.32938,{"lat":423,"lon":422},[426,428],{"name":427,"role":33,"phone":24,"phoneExt":24,"email":24},"Ernesto Sparrelid, MD",{"name":429,"role":33,"phone":24,"phoneExt":24,"email":24},"Martin Delle, MD",{"facility":431,"status":43,"city":432,"state":433,"zip":434,"country":435,"countryCode":436,"cosmosGeoPoint":437,"geoPoint":441,"contacts":442},"Claraspital & Clarunis University Hospital Basel","Basel","Canton of Basel-City","CH-4058","Switzerland","CH",{"type":50,"coordinates":438},[439,440],7.57327,47.55839,{"lat":440,"lon":439},[443,445,447,449,451],{"name":444,"role":33,"phone":24,"phoneExt":24,"email":24},"Otto Kollmar, Prof.",{"name":446,"role":33,"phone":24,"phoneExt":24,"email":24},"Bettina Woelnerhanssen",{"name":448,"role":33,"phone":24,"phoneExt":24,"email":24},"Martin Hoffman, Prof.",{"name":450,"role":33,"phone":24,"phoneExt":24,"email":24},"Gabriel Hess, Dr.",{"name":452,"role":33,"phone":24,"phoneExt":24,"email":24},"Bettina Woelnershanssen",{"facility":454,"status":43,"city":455,"state":24,"zip":456,"country":435,"countryCode":436,"cosmosGeoPoint":457,"geoPoint":461,"contacts":462},"Kantonsspital Winterthur (KSW)","Winterthur","8401",{"type":50,"coordinates":458},[459,460],8.72413,47.50564,{"lat":460,"lon":459},[463,465,467],{"name":464,"role":33,"phone":24,"phoneExt":24,"email":24},"Erik Schadde, MD",{"name":466,"role":33,"phone":24,"phoneExt":24,"email":24},"Sabine Kern",{"name":468,"role":33,"phone":24,"phoneExt":24,"email":24},"Chistoph A Binkert, MD",{"type":470,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100472196","the-dragon-2-trial-100472196",false,"NCT05428735","The DRAGON 2 Trial","An International Multicenter Randomized Controlled Trial to Compare Combined Portal and Hepatic Vein Embolization (PVE\u002FHVE) with PVE Alone in Patients with Colorectal Liver Cancer Metastases (CRLM) and a Small Future Liver Remnant (FLR)","DRAGON 2","Inclusion Criteria:\n\n* Patients with primarily unresectable\u002F potentially resectable CRLM with a FLR \\\u003C30% (\\\u003C40% in chemotherapy damaged livers)\n* Patients with non-resected primary CRC may be included if there is an intention to resect the CRC after the liver treatment (liver first approach) or simultaneously during one of the liver procedures.\n* Patients with resectable or ablatable lung or brain metastases can be included (statement about the resectability of these extrahepatic metastases by a tumor board needs to be available)\n* 18 Years and older\n* Men and women\n* Able to understand the trial and provide informed consent.\n\nExclusion Criteria:\n\n* Pregnant or lactating female.\n* Premenopausal females not able or willing to commit to oral contraception\n* Patients with prohibitive comorbidities, decision made by local team\n* Any patient with non-resectable or non-ablatable extrahepatic disease\n* Patients with hepatic malignancies other than CRLM\n* Progression of disease by RECIST criteria after cytoreduction chemotherapy\n* Complete response after conversion chemotherapy\n* Staging CT and (if indicated) CT\u002FMRI brain that demonstrates non-resectable extrahepatic disease\n* The anatomy of the liver or manifestation of tumors in relation to the liver veins prohibits the use of combined PVE\u002FHVE.","ALL","18 Years",{"count":482,"type":483},348,"ESTIMATED","INTERVENTIONAL",[486],"NA","In the randomized controlled DRAGON 2 trial study subjects will be randomized between two arms, PVE alone (control group) and PVE\u002FHVE (interventional group).",[489,490],"Colorectal Cancer Liver Metastases (CRLM)","Small Future Liver Remnant (FLR)","2024-10-29",{"date":493,"type":494},"2024-11-01","ACTUAL",{"date":496,"type":494},"2022-04-01",{"date":498,"type":483},"2029-06-30",{"name":5,"class":6},24]