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Erbahceci Salik, Dr.",{"facility":643,"status":44,"city":644,"state":26,"zip":26,"country":630,"countryCode":631,"cosmosGeoPoint":645,"geoPoint":649,"contacts":650},"Karolinska University Hospital Stockholm","Stockholm",{"type":51,"coordinates":646},[647,648],18.06871,59.32938,{"lat":648,"lon":647},[651,653],{"name":652,"role":59,"phone":26,"phoneExt":26,"email":26},"E. Sparrelid, Dr.",{"name":654,"role":59,"phone":26,"phoneExt":26,"email":26},"M. Delle, Dr.",{"facility":656,"status":44,"city":657,"state":658,"zip":26,"country":659,"countryCode":660,"cosmosGeoPoint":661,"geoPoint":665,"contacts":666},"Cantonal Hospital Winterthur","Winterthur","Canton of Zurich","Switzerland","CH",{"type":51,"coordinates":662},[663,664],8.72413,47.50564,{"lat":664,"lon":663},[667,669],{"name":668,"role":59,"phone":26,"phoneExt":26,"email":26},"L.F. Grochola, Dr.",{"name":670,"role":59,"phone":26,"phoneExt":26,"email":26},"C.A. 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Hoffmann, Prof.",{"facility":685,"status":44,"city":673,"state":26,"zip":26,"country":659,"countryCode":660,"cosmosGeoPoint":686,"geoPoint":688,"contacts":689},"Universitätsspital Basel",{"type":51,"coordinates":687},[676,677],{"lat":677,"lon":676},[690,691],{"name":681,"role":59,"phone":26,"phoneExt":26,"email":26},{"name":683,"role":59,"phone":26,"phoneExt":26,"email":26},{"facility":693,"status":44,"city":694,"state":26,"zip":26,"country":659,"countryCode":660,"cosmosGeoPoint":695,"geoPoint":699,"contacts":700},"CHUV - Lausanne University Hospital","Lausanne",{"type":51,"coordinates":696},[697,698],6.63282,46.516,{"lat":698,"lon":697},[701,703],{"name":702,"role":59,"phone":26,"phoneExt":26,"email":26},"E. Melloul, Dr.",{"name":704,"role":59,"phone":26,"phoneExt":26,"email":26},"A. Denys, Prof.",{"facility":706,"status":44,"city":707,"state":26,"zip":26,"country":659,"countryCode":660,"cosmosGeoPoint":708,"geoPoint":712,"contacts":713},"Hirslanden Klinik St. Anna","Lucerne",{"type":51,"coordinates":709},[710,711],8.30635,47.05048,{"lat":711,"lon":710},[714],{"name":715,"role":59,"phone":26,"phoneExt":26,"email":26},"E. Schadde, Prof.",{"facility":717,"status":44,"city":718,"state":26,"zip":26,"country":659,"countryCode":660,"cosmosGeoPoint":719,"geoPoint":723,"contacts":724},"Hirslanden Klinik","Zurich",{"type":51,"coordinates":720},[721,722],8.55,47.36667,{"lat":722,"lon":721},[725],{"name":726,"role":59,"phone":26,"phoneExt":26,"email":26},"M. Schiesser, Prof.",{"facility":728,"status":44,"city":729,"state":26,"zip":26,"country":730,"countryCode":731,"cosmosGeoPoint":732,"geoPoint":736,"contacts":737},"Belfast Health and Social Care Trust","Belfast","United Kingdom","UK",{"type":51,"coordinates":733},[734,735],-5.92541,54.59682,{"lat":735,"lon":734},[738],{"name":739,"role":59,"phone":26,"phoneExt":26,"email":26},"D.G. Vass, Dr.",{"facility":741,"status":44,"city":742,"state":26,"zip":26,"country":730,"countryCode":731,"cosmosGeoPoint":743,"geoPoint":747,"contacts":748},"Queen Elizabeth Hospital","Birmingham",{"type":51,"coordinates":744},[745,746],-1.89983,52.48142,{"lat":746,"lon":745},[749,751],{"name":750,"role":59,"phone":26,"phoneExt":26,"email":26},"R. Sutcliffe, Dr.",{"name":752,"role":59,"phone":26,"phoneExt":26,"email":26},"H. Mehrzad, Dr.",{"facility":754,"status":44,"city":755,"state":26,"zip":26,"country":730,"countryCode":731,"cosmosGeoPoint":756,"geoPoint":760,"contacts":761},"Aintree University Hospital","Liverpool",{"type":51,"coordinates":757},[758,759],-2.97794,53.41058,{"lat":759,"lon":758},[762,764],{"name":763,"role":59,"phone":26,"phoneExt":26,"email":26},"R. Díaz-Nieto, Dr.",{"name":765,"role":59,"phone":26,"phoneExt":26,"email":26},"R. Davis",{"facility":767,"status":44,"city":374,"state":26,"zip":26,"country":730,"countryCode":731,"cosmosGeoPoint":768,"geoPoint":772,"contacts":773},"Kings college Hospital",{"type":51,"coordinates":769},[770,771],-0.12574,51.50853,{"lat":771,"lon":770},[774,776],{"name":775,"role":59,"phone":26,"phoneExt":26,"email":26},"K. Menon, Dr.",{"name":777,"role":59,"phone":26,"phoneExt":26,"email":26},"P. Peddu, Dr.",{"facility":779,"status":44,"city":780,"state":26,"zip":26,"country":730,"countryCode":731,"cosmosGeoPoint":781,"geoPoint":785,"contacts":786},"Oxford University Hospitals NHS Foundation Trust","Oxford",{"type":51,"coordinates":782},[783,784],-1.25596,51.75222,{"lat":784,"lon":783},[787,789],{"name":788,"role":59,"phone":26,"phoneExt":26,"email":26},"K.V. Udupa",{"name":790,"role":59,"phone":26,"phoneExt":26,"email":26},"A. MacDonald, Dr.",{"facility":792,"status":44,"city":793,"state":26,"zip":26,"country":730,"countryCode":731,"cosmosGeoPoint":794,"geoPoint":798,"contacts":799},"University Hospital Southampton","Southampton",{"type":51,"coordinates":795},[796,797],-1.40428,50.90395,{"lat":797,"lon":796},[800,802],{"name":801,"role":59,"phone":26,"phoneExt":26,"email":26},"J.N. Primrose, Prof.",{"name":803,"role":59,"phone":26,"phoneExt":26,"email":26},"D. Breen",{"type":805,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100586382","the-dragon-plc-trial-dragon-plc-100586382",false,"NCT06914648","The Dragon PLC Trial (DRAGON-PLC)","The DRAGON PLC Trial - An International Multicenter Randomized Controlled Trial to Compare Combined Portal and Hepatic Vein Embolization (PVE\u002FHVE) With PVE Alone in Primary Liver Cancers.","Inclusion Criteria:\n\n* PLC diagnosis, specifically iCCC, pCCC, and HCC;\n* Requiring PVE due to an FLR volume is \\\u003C30% in normally functioning livers, \\\u003C40% in livers with potentially impaired function e.g. resulting from prior systemic therapy induction or bile duct colonization \u002F transpapillary biliary drainage, or \\\u003C50% in livers with severely impaired function resulting from liver cirrhosis (max. Child Pugh A5) OR function on hepatobiliary scintigraphy (HEBIS) is \\\u003C 2.7 %\u002Fmin\u002Fm2;\n* Age ≥ 18 years;\n* Able to understand the trial and provide informed consent.\n\nExclusion Criteria:\n\n* Liver cirrhosis with a Child-Pugh score of B or C;\n* Presence of portal hypertension;\n* Presence of cholangitis;\n* Pregnant women;\n* Premenopausal females not able\u002Fwilling to commit to contraception (specifically long-acting reversible contraception or hormonal contraception);\n* Patients unresectable due to prohibitive comorbidities (decision made by local multidisciplinary team);\n* Patients with hepatic malignancies other than iCCC, pCCC or HCC;\n* PVE\u002FHVE anatomically not feasible;\n* Any patient with non-resectable or non-ablatable extrahepatic metastatic disease.\n* Unable to understand the study information, study instructions and give informed consent","ALL","18 Years",{"count":816,"type":817},358,"ESTIMATED","INTERVENTIONAL",[820],"NA","The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifically focuses on patients with hepatocellular carcinoma and cholangiocarcinoma.\n\nThe main questions this trial aims to answer are whether combined PVE and HVE increases the proportion of patients who become resectable within 3 weeks and improves 5-year overall survival compared to PVE alone by enhancing liver hypertrophy.\n\nParticipants will:\n\n* Undergo either standard PVE or combined PVE and HVE.\n* Have regular imaging to assess liver resectability.\n* Be monitored for survival outcomes up to 5 years after intervention.",[823,824,825],"Primary Liver Cancer","Hepatocellular Carcinoma (HCC)","Cholangiocarcinoma",[827,828,829,830,831],"Primary liver cancer","Future Liver Remnant","Liver regeneration","Portal Vein Embolization (PVE)","Hepatic Vein Embolization (HVE)","2025-05-12",{"date":834,"type":835},"2025-05-15","ACTUAL",{"date":837,"type":835},"2025-04-01",{"date":839,"type":817},"2032-11-15",{"name":5,"class":6},55]