[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626948":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":45,"collaborators":47,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":20,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":20,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Brown University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Memory Retrieval Task","EXPERIMENTAL","All participants will complete a visual memory encoding and retrieval task during fMRI scanning. The study uses a within-subject design in which each participant completes both a repeated retrieval condition and a time-matched control retrieval condition. This design allows comparison of neural representational changes associated with repeated retrieval while controlling for elapsed time.",[13],"Behavioral: Visual Memory Encoding and Retrieval Task During fMRI",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Visual Memory Encoding and Retrieval Task During fMRI","Participants will study cue-stimulus associations and subsequently retrieve the associated stimuli while undergoing fMRI scanning. Retrieval will occur under two conditions: (1) repeated retrieval, in which stimuli are recalled five times, and (2) control retrieval, in which stimuli are recalled twice with timing matched to the repeated condition. Neural activity patterns during study and recall will be measured using BOLD fMRI.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Serra E Favila, PhD","CONTACT","(401) 863-3486","serra_favila@brown.edu",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Brown University Magnetic MRI Research Facility","RECRUITING","Providence","Rhode Island","02906","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-71.41283,41.82399,{"lat":40,"lon":39},[43],{"name":23,"role":44,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[48],{"name":49,"class":50},"National Institute of General Medical Sciences (NIGMS)","NIH","100626948","the-dynamics-of-representational-change-underlying-recall-100626948",false,"NCT07442266","The Dynamics of Representational Change Underlying Recall","Exclusion Criteria:\n\n* Under the age of 18 or over the age of 40\n* Does not live in the United States or is not a native speaker of English\n* Diagnosis of a neurological disorders, a history of head trauma, or diagnosis of psychiatric disorder\n* Imperfect and uncorrected visual acuity, color blindness, or imperfect hearing\n* Magnetically or mechanically activated implants or other untested metal implants\n* Claustrophobia",true,"ALL","18 Years","40 Years",{"count":62,"type":63},30,"ESTIMATED","INTERVENTIONAL",[66],"NA","The goal of this clinical trial is to examine how repeated memory retrieval changes visual representations in the brain in healthy adult participants. Specifically, the study aims to determine whether repeated recall strengthens or transforms neural representations in visual cortex compared to a time-matched control condition. The main questions it aims to answer are: 1) Does repeated retrieval produce cumulative changes in visual cortical representations compared to a control condition matched for elapsed time? 2) Do these representational changes differ for simple spatial stimuli and complex natural images?\n\nResearchers will compare neural activity patterns during repeated retrieval to those during a control retrieval condition to determine whether repeated recall leads to systematic changes in representational structure beyond those attributable to the passage of time. Participants will: 1) complete two fMRI sessions. 2) Undergo a localizer session including anatomical imaging, population receptive field (pRF) mapping, and a visual category localizer task. 3) Study cue-stimulus pairs consisting of either simple spatial patterns or natural images. 4) Recall previously studied stimuli multiple times during repeated and control retrieval conditions while undergoing fMRI scanning. Brain activity patterns during study and recall will be compared to assess how repeated retrieval influences the structure and tuning of visual representations.",[69],"Episodic Memory","2026-02-27",{"date":72,"type":73},"2026-03-02","ACTUAL",{"date":75,"type":73},"2026-02-03",{"date":77,"type":63},"2026-08",{"name":5,"class":6},1]