[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100378235":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":35,"locations":44,"responsibleParty":1351,"collaborators":1353,"id":1359,"slug":1360,"hasResults":1361,"nctId":1362,"briefTitle":1363,"officialTitle":1364,"acronym":1365,"eligibilityCriteria":1366,"healthyVolunteers":1361,"sex":1367,"minAge":1368,"maxAge":18,"enrollmentInfo":1369,"targetDuration":18,"studyType":1372,"phases":1373,"briefSummary":1375,"conditions":1376,"keywords":1378,"overallStatus":47,"whyStopped":18,"lastUpdateSubmitDate":1384,"lastUpdatePostDateStruct":1385,"startDateStruct":1388,"completionDateStruct":1390,"leadSponsor":1392,"locationsCount":1393},{"fullName":5,"class":6},"University of Leicester","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Aortic valve replacement","ACTIVE_COMPARATOR","Participants randomised to AVR will be investigated and managed according to local protocols and standard practice. Participants will be placed on the waiting list with the aim that surgery will be performed within 3 months, dependent on local hospitals' waiting lists.",[13],"Procedure: Aortic valve replacement",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B: Expectant management","NO_INTERVENTION","Participants randomised to expectant management will continue to have regular monitoring of their condition in line with the procedures and standard practices of their hospital.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Aortic valve replacement","Participants will be assessed by a member of the surgical team performing aortic valve replacement (AVR), and by any other relevant medical professionals identified by the doctors overseeing their care in hospital. When deemed ready for AVR, a member of the surgical team will ask for consent to proceed with the AVR. They will discuss the surgical procedure, covering information on the basic technical procedure, risks and expected recovery time.",[9],[26,29,32],{"name":27,"affiliation":5,"role":28},"Gerry McCann, Prof","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":31,"role":28},"Graham Hillis, Prof","The University of Western Australia",{"name":33,"affiliation":34,"role":28},"Ralph Stewart, Prof","University of Aukland",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Carla Richardson","CONTACT","+44 0116-229-7936","7936","easyas@leicester.ac.uk",{"name":43,"role":38,"phone":18,"phoneExt":18,"email":41},"Michael Walters",[45,62,75,87,99,111,124,136,148,161,170,183,195,208,217,229,241,253,265,277,289,303,315,327,340,351,365,377,389,403,416,427,442,455,466,479,492,504,517,530,543,556,569,582,595,608,620,632,644,657,671,683,695,706,718,730,742,754,766,778,792,804,816,827,841,853,865,877,885,893,904,916,928,940,952,964,976,985,995,1007,1016,1025,1033,1042,1051,1059,1071,1083,1093,1105,1117,1129,1138,1150,1164,1176,1188,1200,1214,1226,1238,1250,1261,1273,1285,1297,1308,1320,1331,1342],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Canberra Hospital","RECRUITING","Garran","Australian Capital Territory","2605","Australia","AU",{"type":54,"coordinates":55},"Point",[56,57],149.10846,-35.34206,{"lat":57,"lon":56},[60],{"name":61,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Walter Abhayaratna",{"facility":63,"status":47,"city":64,"state":65,"zip":66,"country":51,"countryCode":52,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Liverpool Hospital","Liverpool","New South Wales","2170",{"type":54,"coordinates":68},[69,70],150.92588,-33.91938,{"lat":70,"lon":69},[73],{"name":74,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Dominic Leung",{"facility":76,"status":47,"city":77,"state":65,"zip":78,"country":51,"countryCode":52,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Royal North Shore Hospital","St Leonards","2065",{"type":54,"coordinates":80},[81,82],151.19836,-33.82344,{"lat":82,"lon":81},[85],{"name":86,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Ravinay Bhindi",{"facility":88,"status":47,"city":89,"state":65,"zip":90,"country":51,"countryCode":52,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Westmead Hospital","Westmead","2145",{"type":54,"coordinates":92},[93,94],150.98768,-33.80383,{"lat":94,"lon":93},[97],{"name":98,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Dylan Wynne",{"facility":100,"status":47,"city":101,"state":65,"zip":102,"country":51,"countryCode":52,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Wollongong Hospital","Wollongong","2500",{"type":54,"coordinates":104},[105,106],150.89345,-34.424,{"lat":106,"lon":105},[109],{"name":110,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Edward Danson",{"facility":112,"status":47,"city":113,"state":114,"zip":115,"country":51,"countryCode":52,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Prince Charles Hospital","Chermside","Queensland","4032",{"type":54,"coordinates":117},[118,119],153.03062,-27.38472,{"lat":119,"lon":118},[122],{"name":123,"role":38,"phone":18,"phoneExt":18,"email":18},"Dale Murdoch",{"facility":125,"status":47,"city":126,"state":114,"zip":127,"country":51,"countryCode":52,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Townsville Hospital","Douglas","4814",{"type":54,"coordinates":129},[130,131],146.75234,-19.32394,{"lat":131,"lon":130},[134],{"name":135,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Lim Eng",{"facility":137,"status":47,"city":138,"state":114,"zip":139,"country":51,"countryCode":52,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"The Gold Coast Hospital","Southport","4215",{"type":54,"coordinates":141},[142,143],153.39796,-27.96724,{"lat":143,"lon":142},[146],{"name":147,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Kuljit Singh",{"facility":149,"status":47,"city":150,"state":151,"zip":152,"country":51,"countryCode":52,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"Royal Adelaide Hospital","Adelaide","South Australia","5000",{"type":54,"coordinates":154},[155,156],138.59863,-34.92866,{"lat":156,"lon":155},[159],{"name":160,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Jerrett Lau",{"facility":162,"status":47,"city":150,"state":151,"zip":163,"country":51,"countryCode":52,"cosmosGeoPoint":164,"geoPoint":166,"contacts":167},"Flinders Medical Centre","SA 5042",{"type":54,"coordinates":165},[155,156],{"lat":156,"lon":155},[168],{"name":169,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Joseph Selvanayagam",{"facility":171,"status":47,"city":172,"state":173,"zip":174,"country":51,"countryCode":52,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"Monash Health","Clayton","Victoria","3168",{"type":54,"coordinates":176},[177,178],145.11667,-37.91667,{"lat":178,"lon":177},[181],{"name":182,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Julian Smith",{"facility":184,"status":47,"city":185,"state":173,"zip":186,"country":51,"countryCode":52,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"University Hospital Geelong","Geelong","3220",{"type":54,"coordinates":188},[189,190],144.36069,-38.14711,{"lat":190,"lon":189},[193],{"name":194,"role":38,"phone":18,"phoneExt":18,"email":18},"A\u002FProfessor John Amerena",{"facility":196,"status":47,"city":197,"state":198,"zip":199,"country":51,"countryCode":52,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Fiona Stanley Hospital","Perth","Western Australia","6150",{"type":54,"coordinates":201},[202,203],115.8614,-31.95224,{"lat":203,"lon":202},[206],{"name":207,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Gerald Yong",{"facility":209,"status":47,"city":197,"state":198,"zip":210,"country":51,"countryCode":52,"cosmosGeoPoint":211,"geoPoint":213,"contacts":214},"Royal Perth Hospital","WA6000",{"type":54,"coordinates":212},[202,203],{"lat":203,"lon":202},[215],{"name":216,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Graham Hillis",{"facility":218,"status":47,"city":219,"state":18,"zip":220,"country":51,"countryCode":52,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"Lyell McEwin Hospital","Elizabeth Vale","SA 5112",{"type":54,"coordinates":222},[223,224],138.66819,-34.74857,{"lat":224,"lon":223},[227],{"name":228,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Luan Huynh",{"facility":230,"status":47,"city":231,"state":18,"zip":232,"country":51,"countryCode":52,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Northern Hospital","Epping","VIC 3076",{"type":54,"coordinates":234},[235,236],145.03333,-37.65,{"lat":236,"lon":235},[239],{"name":240,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Chiew Wong",{"facility":242,"status":47,"city":243,"state":18,"zip":244,"country":51,"countryCode":52,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Royal Hobart Hospital","Hobart","TAS 7000",{"type":54,"coordinates":246},[247,248],147.32941,-42.87936,{"lat":248,"lon":247},[251],{"name":252,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Ashutosh Hardikar",{"facility":254,"status":47,"city":255,"state":18,"zip":256,"country":51,"countryCode":52,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"Nepean Hospital","Kingswood","NSW 2747",{"type":54,"coordinates":258},[259,260],150.72346,-33.75614,{"lat":260,"lon":259},[263],{"name":264,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Kaz Negishi",{"facility":266,"status":47,"city":267,"state":18,"zip":268,"country":51,"countryCode":52,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"John Hunter Hospital","New Lambton Heights","NSW 2305",{"type":54,"coordinates":270},[271,272],151.69364,-32.92466,{"lat":272,"lon":271},[275],{"name":276,"role":38,"phone":18,"phoneExt":18,"email":18},"A\u002FProfessor Aaron Sverdlov",{"facility":278,"status":47,"city":279,"state":18,"zip":280,"country":51,"countryCode":52,"cosmosGeoPoint":281,"geoPoint":285,"contacts":286},"Royal Darwin Hospital","Tiwi","TIWI NT 0810",{"type":54,"coordinates":282},[283,284],130.878,-12.35876,{"lat":284,"lon":283},[287],{"name":288,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Hussam Tayeb",{"facility":290,"status":47,"city":291,"state":18,"zip":292,"country":293,"countryCode":294,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"Sint-Jan Hospital","Bruges","8000","Belgium","BE",{"type":54,"coordinates":296},[297,298],3.22424,51.20892,{"lat":298,"lon":297},[301],{"name":302,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Philippe Debonnaire",{"facility":304,"status":47,"city":305,"state":18,"zip":306,"country":293,"countryCode":294,"cosmosGeoPoint":307,"geoPoint":311,"contacts":312},"Ziekenhuis Oost-Limburg","Genk","3600",{"type":54,"coordinates":308},[309,310],5.50082,50.965,{"lat":310,"lon":309},[313],{"name":314,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Philippe Bertrand",{"facility":316,"status":47,"city":317,"state":18,"zip":318,"country":293,"countryCode":294,"cosmosGeoPoint":319,"geoPoint":323,"contacts":324},"University Hospital of Brussels","Jette","1090",{"type":54,"coordinates":320},[321,322],4.33419,50.87309,{"lat":322,"lon":321},[325],{"name":326,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Xavier Galloo",{"facility":328,"status":47,"city":329,"state":18,"zip":18,"country":330,"countryCode":331,"cosmosGeoPoint":332,"geoPoint":336,"contacts":337},"Frisius Medical Center","Leeuwarden","Netherlands","NL",{"type":54,"coordinates":333},[334,335],5.80973,53.20271,{"lat":335,"lon":334},[338],{"name":339,"role":38,"phone":18,"phoneExt":18,"email":18},"Olga Bondarenko",{"facility":341,"status":47,"city":342,"state":18,"zip":18,"country":330,"countryCode":331,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"Radboud University Medical Center","Nijmegen",{"type":54,"coordinates":344},[345,346],5.85278,51.8425,{"lat":346,"lon":345},[349],{"name":350,"role":38,"phone":18,"phoneExt":18,"email":18},"Saloua ElMessaoudi",{"facility":352,"status":47,"city":353,"state":18,"zip":354,"country":355,"countryCode":356,"cosmosGeoPoint":357,"geoPoint":361,"contacts":362},"Auckland City Hospital","Auckland","1023","New Zealand","NZ",{"type":54,"coordinates":358},[359,360],174.76349,-36.84853,{"lat":360,"lon":359},[363],{"name":364,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Ralph Stewart",{"facility":366,"status":47,"city":367,"state":18,"zip":368,"country":355,"countryCode":356,"cosmosGeoPoint":369,"geoPoint":373,"contacts":374},"Christchurch Hospital","Christchurch","8011",{"type":54,"coordinates":370},[371,372],172.63333,-43.53333,{"lat":372,"lon":371},[375],{"name":376,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Philip Adamson",{"facility":378,"status":47,"city":379,"state":18,"zip":380,"country":355,"countryCode":356,"cosmosGeoPoint":381,"geoPoint":385,"contacts":386},"Dunedin Hospital","Dunedin","9016",{"type":54,"coordinates":382},[383,384],170.50361,-45.87416,{"lat":384,"lon":383},[387],{"name":388,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Sean Coffey",{"facility":390,"status":47,"city":391,"state":18,"zip":392,"country":393,"countryCode":394,"cosmosGeoPoint":395,"geoPoint":399,"contacts":400},"Institute of Cardiovascular Diseases","Kamenitz","21204","Serbia","RS",{"type":54,"coordinates":396},[397,398],19.84263,45.22334,{"lat":398,"lon":397},[401],{"name":402,"role":38,"phone":18,"phoneExt":18,"email":18},"Lazar Velicki",{"facility":404,"status":47,"city":405,"state":18,"zip":18,"country":406,"countryCode":407,"cosmosGeoPoint":408,"geoPoint":412,"contacts":413},"Hospital Germans Trias","Barcelona","Spain","ES",{"type":54,"coordinates":409},[410,411],2.15899,41.38879,{"lat":411,"lon":410},[414],{"name":415,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Victoria Delgado",{"facility":417,"status":47,"city":418,"state":18,"zip":18,"country":406,"countryCode":407,"cosmosGeoPoint":419,"geoPoint":423,"contacts":424},"University Hospital of Navarra","Pamplona",{"type":54,"coordinates":420},[421,422],-1.64323,42.81687,{"lat":422,"lon":421},[425],{"name":426,"role":38,"phone":18,"phoneExt":18,"email":18},"Rafael Sadaba",{"facility":428,"status":47,"city":429,"state":430,"zip":431,"country":432,"countryCode":433,"cosmosGeoPoint":434,"geoPoint":438,"contacts":439},"University Hospital of North Durham","Durham","County Durham","DH1 5TW","United Kingdom","UK",{"type":54,"coordinates":435},[436,437],-1.57566,54.77676,{"lat":437,"lon":436},[440],{"name":441,"role":38,"phone":18,"phoneExt":18,"email":18},"Darragh Twomey",{"facility":443,"status":47,"city":444,"state":445,"zip":446,"country":432,"countryCode":433,"cosmosGeoPoint":447,"geoPoint":451,"contacts":452},"Glan Clwyd Hospital","Bodelwyddan","Denbighshire","LL18 5UJ",{"type":54,"coordinates":448},[449,450],-3.50078,53.26827,{"lat":450,"lon":449},[453],{"name":454,"role":38,"phone":18,"phoneExt":18,"email":18},"Satheesh Nair",{"facility":456,"status":457,"city":458,"state":459,"zip":460,"country":432,"countryCode":433,"cosmosGeoPoint":461,"geoPoint":465,"contacts":18},"Dorset County Hospital","WITHDRAWN","Dorchester","Dorset","DT1 2JY",{"type":54,"coordinates":462},[463,464],-2.43333,50.71667,{"lat":464,"lon":463},{"facility":467,"status":47,"city":468,"state":469,"zip":470,"country":432,"countryCode":433,"cosmosGeoPoint":471,"geoPoint":475,"contacts":476},"Basingstoke and North Hampshire Hospital","Basingstoke","Hampshire","RG24 9NA",{"type":54,"coordinates":472},[473,474],-1.08708,51.26249,{"lat":474,"lon":473},[477],{"name":478,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Jason Glover",{"facility":480,"status":47,"city":481,"state":482,"zip":483,"country":432,"countryCode":433,"cosmosGeoPoint":484,"geoPoint":488,"contacts":489},"University Hospitals Leicester, Glenfield","Leicester","Leicestershire","LE3 9QP",{"type":54,"coordinates":485},[486,487],-1.13169,52.6386,{"lat":487,"lon":486},[490],{"name":491,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Anvesha Singh",{"facility":493,"status":47,"city":64,"state":494,"zip":495,"country":432,"countryCode":433,"cosmosGeoPoint":496,"geoPoint":500,"contacts":501},"Royal Liverpool Hospital","Merseyside","L7 8YE",{"type":54,"coordinates":497},[498,499],-2.97794,53.41058,{"lat":499,"lon":498},[502],{"name":503,"role":38,"phone":18,"phoneExt":18,"email":18},"Prathap Kanagala",{"facility":505,"status":47,"city":506,"state":507,"zip":508,"country":432,"countryCode":433,"cosmosGeoPoint":509,"geoPoint":513,"contacts":514},"Norfolk and Norwich University Hospital","Norwich","Norfolk","NR4 7UY",{"type":54,"coordinates":510},[511,512],1.29834,52.62783,{"lat":512,"lon":511},[515],{"name":516,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Vassilios Vassiliou",{"facility":518,"status":47,"city":519,"state":520,"zip":521,"country":432,"countryCode":433,"cosmosGeoPoint":522,"geoPoint":526,"contacts":527},"Scunthorpe General Hospital","Scunthorpe","North Lincolnshire","DN15 7BH",{"type":54,"coordinates":523},[524,525],-0.65437,53.57905,{"lat":525,"lon":524},[528],{"name":529,"role":38,"phone":18,"phoneExt":18,"email":18},"Rashed Hossain",{"facility":531,"status":47,"city":532,"state":533,"zip":534,"country":432,"countryCode":433,"cosmosGeoPoint":535,"geoPoint":539,"contacts":540},"Kettering General Hospital","Kettering","Northamptonshire","NN16 8UZ",{"type":54,"coordinates":536},[537,538],-0.72571,52.39836,{"lat":538,"lon":537},[541],{"name":542,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Kai Hogrefe",{"facility":544,"status":47,"city":545,"state":546,"zip":547,"country":432,"countryCode":433,"cosmosGeoPoint":548,"geoPoint":552,"contacts":553},"Wansbeck General Hospital","Ashington","Northumberland","NE63 9JJ",{"type":54,"coordinates":549},[550,551],-1.56412,55.17719,{"lat":551,"lon":550},[554],{"name":555,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr David Ripley",{"facility":557,"status":47,"city":558,"state":559,"zip":560,"country":432,"countryCode":433,"cosmosGeoPoint":561,"geoPoint":565,"contacts":566},"Raigmore Hospital","Inverness","Scotland","IV2 3UJ",{"type":54,"coordinates":562},[563,564],-4.22398,57.47908,{"lat":564,"lon":563},[567],{"name":568,"role":38,"phone":18,"phoneExt":18,"email":18},"Stephen Leslie",{"facility":570,"status":47,"city":571,"state":572,"zip":573,"country":432,"countryCode":433,"cosmosGeoPoint":574,"geoPoint":578,"contacts":579},"Musgrove Park Hospital","Taunton","Somerset","TA1 5DA",{"type":54,"coordinates":575},[576,577],-3.10293,51.01494,{"lat":577,"lon":576},[580],{"name":581,"role":38,"phone":18,"phoneExt":18,"email":18},"Thomas Rees",{"facility":583,"status":47,"city":584,"state":585,"zip":586,"country":432,"countryCode":433,"cosmosGeoPoint":587,"geoPoint":591,"contacts":592},"Morriston Hospital","Swansea","Wales","SA6 6NL",{"type":54,"coordinates":588},[589,590],-3.94323,51.62079,{"lat":590,"lon":589},[593],{"name":594,"role":38,"phone":18,"phoneExt":18,"email":18},"Alexander Chase",{"facility":596,"status":47,"city":597,"state":598,"zip":599,"country":432,"countryCode":433,"cosmosGeoPoint":600,"geoPoint":604,"contacts":605},"Russells Hall Hospital","Dudley","West Midlands","DY1 2HQ",{"type":54,"coordinates":601},[602,603],-2.08333,52.5,{"lat":603,"lon":602},[606],{"name":607,"role":38,"phone":18,"phoneExt":18,"email":18},"Craig Barr",{"facility":609,"status":47,"city":610,"state":598,"zip":611,"country":432,"countryCode":433,"cosmosGeoPoint":612,"geoPoint":616,"contacts":617},"George Eliot Hospital","Nuneaton","CV10 7DJ",{"type":54,"coordinates":613},[614,615],-1.46523,52.52323,{"lat":615,"lon":614},[618],{"name":619,"role":38,"phone":18,"phoneExt":18,"email":18},"Suresh Krishnamoorthy",{"facility":621,"status":47,"city":622,"state":598,"zip":623,"country":432,"countryCode":433,"cosmosGeoPoint":624,"geoPoint":628,"contacts":629},"Walsall Manor Hospital","Walsall","WS2 9PS",{"type":54,"coordinates":625},[626,627],-1.98396,52.58528,{"lat":627,"lon":626},[630],{"name":631,"role":38,"phone":18,"phoneExt":18,"email":18},"Rumi Jaumdally",{"facility":633,"status":47,"city":634,"state":598,"zip":635,"country":432,"countryCode":433,"cosmosGeoPoint":636,"geoPoint":640,"contacts":641},"Sandwell General Hospital","West Bromwich","B71 4HJ",{"type":54,"coordinates":637},[638,639],-1.9945,52.51868,{"lat":639,"lon":638},[642],{"name":643,"role":38,"phone":18,"phoneExt":18,"email":18},"Abdul Maher",{"facility":645,"status":47,"city":646,"state":647,"zip":648,"country":432,"countryCode":433,"cosmosGeoPoint":649,"geoPoint":653,"contacts":654},"Wycombe Hospital","High Wycombe","Wycombe","HP11 2TT",{"type":54,"coordinates":650},[651,652],-0.74934,51.62907,{"lat":652,"lon":651},[655],{"name":656,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Piers Clifford",{"facility":658,"status":47,"city":659,"state":18,"zip":660,"country":432,"countryCode":433,"cosmosGeoPoint":661,"geoPoint":665,"contacts":666},"Aberdeen Royal Infirmary","Aberdeen","AB25 2ZN",{"type":54,"coordinates":662},[663,664],-2.09814,57.14369,{"lat":664,"lon":663},[667,669],{"name":668,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Ciprian Dospinescu",{"name":670,"role":38,"phone":18,"phoneExt":18,"email":18},"Mr Hussein El-Shafei",{"facility":672,"status":47,"city":673,"state":18,"zip":674,"country":432,"countryCode":433,"cosmosGeoPoint":675,"geoPoint":679,"contacts":680},"Aintree University Hospital","Aintree","L9 7AL",{"type":54,"coordinates":676},[677,678],-2.95202,53.47538,{"lat":678,"lon":677},[681],{"name":682,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Prathap Kanagala",{"facility":684,"status":47,"city":685,"state":18,"zip":686,"country":432,"countryCode":433,"cosmosGeoPoint":687,"geoPoint":691,"contacts":692},"University Hospital Ayr","Ayr","KA6 6DX",{"type":54,"coordinates":688},[689,690],-4.63393,55.46273,{"lat":690,"lon":689},[693],{"name":694,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Jim McGowan",{"facility":696,"status":47,"city":697,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":698,"geoPoint":702,"contacts":703},"Barnsley Hospital NHS Foundation Trust","Barnsley",{"type":54,"coordinates":699},[700,701],-1.48333,53.55,{"lat":701,"lon":700},[704],{"name":705,"role":38,"phone":18,"phoneExt":18,"email":18},"Deoraj Zamfar",{"facility":707,"status":47,"city":708,"state":18,"zip":709,"country":432,"countryCode":433,"cosmosGeoPoint":710,"geoPoint":714,"contacts":715},"Basildon University Hospital","Basildon","SS16 5NL",{"type":54,"coordinates":711},[712,713],0.45782,51.56844,{"lat":713,"lon":712},[716],{"name":717,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Jason Dungu",{"facility":719,"status":47,"city":720,"state":18,"zip":721,"country":432,"countryCode":433,"cosmosGeoPoint":722,"geoPoint":726,"contacts":727},"Queen Elizabeth Hospital","Birmingham","B15 2GW",{"type":54,"coordinates":723},[724,725],-1.89983,52.48142,{"lat":725,"lon":724},[728],{"name":729,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Rick Steeds",{"facility":731,"status":47,"city":732,"state":18,"zip":733,"country":432,"countryCode":433,"cosmosGeoPoint":734,"geoPoint":738,"contacts":739},"Blackpool Victoria Hospital","Blackpool","FY3 8NR",{"type":54,"coordinates":735},[736,737],-3.05,53.81667,{"lat":737,"lon":736},[740],{"name":741,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Nidal Bittar",{"facility":743,"status":47,"city":744,"state":18,"zip":745,"country":432,"countryCode":433,"cosmosGeoPoint":746,"geoPoint":750,"contacts":751},"Royal Sussex County Hospital","Brighton","BN2 5BE",{"type":54,"coordinates":747},[748,749],-0.13947,50.82838,{"lat":749,"lon":748},[752],{"name":753,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr David Hildick-Smith",{"facility":755,"status":47,"city":756,"state":18,"zip":757,"country":432,"countryCode":433,"cosmosGeoPoint":758,"geoPoint":762,"contacts":763},"North Cumbria Integrated Care","Carlisle","CA2 7AF",{"type":54,"coordinates":759},[760,761],-2.9382,54.8951,{"lat":761,"lon":760},[764],{"name":765,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Rhidian Shelton",{"facility":767,"status":47,"city":768,"state":18,"zip":769,"country":432,"countryCode":433,"cosmosGeoPoint":770,"geoPoint":774,"contacts":775},"Chesterfield Royal Hospital","Chesterfield","S44 5BL",{"type":54,"coordinates":771},[772,773],-1.41667,53.25,{"lat":773,"lon":772},[776],{"name":777,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Justin Cooke",{"facility":779,"status":47,"city":780,"state":18,"zip":781,"country":432,"countryCode":433,"cosmosGeoPoint":782,"geoPoint":786,"contacts":787},"University Hospital Coventry & Warwickshire","Coventry","CV2 2DX",{"type":54,"coordinates":783},[784,785],-1.51217,52.40656,{"lat":785,"lon":784},[788,790],{"name":789,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Luke Tapp",{"name":791,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Jamal Khan",{"facility":793,"status":47,"city":794,"state":18,"zip":795,"country":432,"countryCode":433,"cosmosGeoPoint":796,"geoPoint":800,"contacts":801},"County Durham and Darlington NHS Foundation Trust","Darlington","DL3 6HX",{"type":54,"coordinates":797},[798,799],-1.55039,54.52429,{"lat":799,"lon":798},[802],{"name":803,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Darragh Twomey",{"facility":805,"status":47,"city":806,"state":18,"zip":807,"country":432,"countryCode":433,"cosmosGeoPoint":808,"geoPoint":812,"contacts":813},"Doncaster Royal Infirmary","Doncaster","DN2 5LT",{"type":54,"coordinates":809},[810,811],-1.13116,53.52285,{"lat":811,"lon":810},[814],{"name":815,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Gillian Payne",{"facility":817,"status":47,"city":818,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":819,"geoPoint":823,"contacts":824},"Ninewells Hospital","Dundee",{"type":54,"coordinates":820},[821,822],-2.97489,56.46913,{"lat":822,"lon":821},[825],{"name":826,"role":38,"phone":18,"phoneExt":18,"email":18},"Chim Lang",{"facility":828,"status":47,"city":829,"state":18,"zip":830,"country":432,"countryCode":433,"cosmosGeoPoint":831,"geoPoint":835,"contacts":836},"The Royal Infirmary of Edinburgh","Edinburgh","EH16 4SA",{"type":54,"coordinates":832},[833,834],-3.19648,55.95206,{"lat":834,"lon":833},[837,839],{"name":838,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Marc Dweck",{"name":840,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor David Newby",{"facility":842,"status":47,"city":843,"state":18,"zip":844,"country":432,"countryCode":433,"cosmosGeoPoint":845,"geoPoint":849,"contacts":850},"Royal Devon & Exeter Hospital","Exeter","EX2 5DW",{"type":54,"coordinates":846},[847,848],-3.52751,50.7236,{"lat":848,"lon":847},[851],{"name":852,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Andrew Ludman",{"facility":854,"status":47,"city":855,"state":18,"zip":856,"country":432,"countryCode":433,"cosmosGeoPoint":857,"geoPoint":861,"contacts":862},"Gateshead Health NHS Foundation Trust","Gateshead","NE9 6SX",{"type":54,"coordinates":858},[859,860],-1.60168,54.96209,{"lat":860,"lon":859},[863],{"name":864,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Ashfaq Mohammed",{"facility":866,"status":47,"city":867,"state":18,"zip":868,"country":432,"countryCode":433,"cosmosGeoPoint":869,"geoPoint":873,"contacts":874},"Golden Jubilee National Hospital","Glasgow","G81 4DY",{"type":54,"coordinates":870},[871,872],-4.25763,55.86515,{"lat":872,"lon":871},[875],{"name":876,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Nawwar Al-Attar",{"facility":878,"status":47,"city":867,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":879,"geoPoint":881,"contacts":882},"Glasgow Royal Infirmary",{"type":54,"coordinates":880},[871,872],{"lat":872,"lon":871},[883],{"name":884,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Stuart Watkins",{"facility":886,"status":47,"city":867,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":887,"geoPoint":889,"contacts":890},"Queen Elizabeth University Hospital",{"type":54,"coordinates":888},[871,872],{"lat":872,"lon":871},[891],{"name":892,"role":38,"phone":18,"phoneExt":18,"email":18},"Fraser Graham",{"facility":894,"status":47,"city":895,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":896,"geoPoint":900,"contacts":901},"Gloucestershire Hospitals NHS Foundation","Gloucester",{"type":54,"coordinates":897},[898,899],-2.2431,51.86568,{"lat":899,"lon":898},[902],{"name":903,"role":38,"phone":18,"phoneExt":18,"email":18},"Val Nikolaidou",{"facility":905,"status":47,"city":906,"state":18,"zip":907,"country":432,"countryCode":433,"cosmosGeoPoint":908,"geoPoint":912,"contacts":913},"Huddersfield Royal Infirmary","Huddersfield","HD3 3EA",{"type":54,"coordinates":909},[910,911],-1.78416,53.64904,{"lat":911,"lon":910},[914],{"name":915,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Hossam El Mahy",{"facility":917,"status":47,"city":918,"state":18,"zip":919,"country":432,"countryCode":433,"cosmosGeoPoint":920,"geoPoint":924,"contacts":925},"West Middlesex University Hospital","Isleworth","TW7 6AF",{"type":54,"coordinates":921},[922,923],-0.34246,51.47518,{"lat":923,"lon":922},[926],{"name":927,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Gajen Sunthar Kanaganayagam",{"facility":929,"status":47,"city":930,"state":18,"zip":931,"country":432,"countryCode":433,"cosmosGeoPoint":932,"geoPoint":936,"contacts":937},"Airedale General Hospital","Keighley","BD20 6TD",{"type":54,"coordinates":933},[934,935],-1.90664,53.86791,{"lat":935,"lon":934},[938],{"name":939,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Haqeel Jamil",{"facility":941,"status":47,"city":942,"state":18,"zip":943,"country":432,"countryCode":433,"cosmosGeoPoint":944,"geoPoint":948,"contacts":949},"University Hospital Crosshouse","Kilmarnock","KA2 0BE",{"type":54,"coordinates":945},[946,947],-4.49581,55.61171,{"lat":947,"lon":946},[950],{"name":951,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Angie Ghattas",{"facility":953,"status":47,"city":954,"state":18,"zip":955,"country":432,"countryCode":433,"cosmosGeoPoint":956,"geoPoint":960,"contacts":961},"Leeds General Infirmary","Leeds","LS1 3EX",{"type":54,"coordinates":957},[958,959],-1.54785,53.79648,{"lat":959,"lon":958},[962],{"name":963,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor John Greenwood",{"facility":965,"status":47,"city":966,"state":18,"zip":967,"country":432,"countryCode":433,"cosmosGeoPoint":968,"geoPoint":972,"contacts":973},"Lincoln County Hospital","Lincoln","LN2 5QY",{"type":54,"coordinates":969},[970,971],-0.53792,53.22683,{"lat":971,"lon":970},[974],{"name":975,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Kelvin Lee",{"facility":977,"status":47,"city":64,"state":18,"zip":978,"country":432,"countryCode":433,"cosmosGeoPoint":979,"geoPoint":981,"contacts":982},"Liverpool Heart and Chest Hospital","L14 3PE",{"type":54,"coordinates":980},[498,499],{"lat":499,"lon":498},[983],{"name":984,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Timothy Fairbairn",{"facility":493,"status":986,"city":64,"state":18,"zip":987,"country":432,"countryCode":433,"cosmosGeoPoint":988,"geoPoint":990,"contacts":991},"NOT_YET_RECRUITING","L7 8XP",{"type":54,"coordinates":989},[498,499],{"lat":499,"lon":498},[992,993],{"name":682,"role":38,"phone":18,"phoneExt":18,"email":18},{"name":994,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Michael Fisher",{"facility":996,"status":47,"city":997,"state":18,"zip":998,"country":432,"countryCode":433,"cosmosGeoPoint":999,"geoPoint":1003,"contacts":1004},"St Bartholomew's Hospital","London","EC1A 7BE",{"type":54,"coordinates":1000},[1001,1002],-0.12574,51.50853,{"lat":1002,"lon":1001},[1005],{"name":1006,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Thomas Treibel",{"facility":1008,"status":47,"city":997,"state":18,"zip":1009,"country":432,"countryCode":433,"cosmosGeoPoint":1010,"geoPoint":1012,"contacts":1013},"St Thomas' Hospital","SE1 7EH",{"type":54,"coordinates":1011},[1001,1002],{"lat":1002,"lon":1001},[1014],{"name":1015,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Ronak Rajani",{"facility":1017,"status":47,"city":997,"state":18,"zip":1018,"country":432,"countryCode":433,"cosmosGeoPoint":1019,"geoPoint":1021,"contacts":1022},"University Hospital Lewisham","SE13 6LH",{"type":54,"coordinates":1020},[1001,1002],{"lat":1002,"lon":1001},[1023],{"name":1024,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Amar Singh",{"facility":1026,"status":47,"city":997,"state":18,"zip":1027,"country":432,"countryCode":433,"cosmosGeoPoint":1028,"geoPoint":1030,"contacts":1031},"Chelsea and Westminster Hospital","SW10 9NH",{"type":54,"coordinates":1029},[1001,1002],{"lat":1002,"lon":1001},[1032],{"name":927,"role":38,"phone":18,"phoneExt":18,"email":18},{"facility":1034,"status":47,"city":997,"state":18,"zip":1035,"country":432,"countryCode":433,"cosmosGeoPoint":1036,"geoPoint":1038,"contacts":1039},"St George's Hospital","SW17 0QT",{"type":54,"coordinates":1037},[1001,1002],{"lat":1002,"lon":1001},[1040],{"name":1041,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Sami Firoozi",{"facility":1043,"status":47,"city":997,"state":18,"zip":1044,"country":432,"countryCode":433,"cosmosGeoPoint":1045,"geoPoint":1047,"contacts":1048},"Cleveland Clinic London Hospital","SW1X 7HY",{"type":54,"coordinates":1046},[1001,1002],{"lat":1002,"lon":1001},[1049],{"name":1050,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Guy Llyod",{"facility":1052,"status":47,"city":997,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":1053,"geoPoint":1055,"contacts":1056},"Imperial College Healthcare NHS Trust",{"type":54,"coordinates":1054},[1001,1002],{"lat":1002,"lon":1001},[1057],{"name":1058,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Jamil Mayet",{"facility":1060,"status":47,"city":1061,"state":18,"zip":1062,"country":432,"countryCode":433,"cosmosGeoPoint":1063,"geoPoint":1067,"contacts":1068},"Maidstone & Tunbridge Wells Hospital","Maidstone","ME16 9QQ",{"type":54,"coordinates":1064},[1065,1066],0.51667,51.26667,{"lat":1066,"lon":1065},[1069],{"name":1070,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Timothy Williams",{"facility":1072,"status":47,"city":1073,"state":18,"zip":1074,"country":432,"countryCode":433,"cosmosGeoPoint":1075,"geoPoint":1079,"contacts":1080},"Wythenshawe Hospital","Manchester","M23 9LT",{"type":54,"coordinates":1076},[1077,1078],-2.23743,53.48095,{"lat":1078,"lon":1077},[1081],{"name":1082,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Laura Dobson",{"facility":1084,"status":47,"city":1073,"state":18,"zip":1085,"country":432,"countryCode":433,"cosmosGeoPoint":1086,"geoPoint":1088,"contacts":1089},"North Manchester General Hospital","M8 5RB",{"type":54,"coordinates":1087},[1077,1078],{"lat":1078,"lon":1077},[1090,1091],{"name":1082,"role":38,"phone":18,"phoneExt":18,"email":18},{"name":1092,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Ahmed Adlan",{"facility":1094,"status":47,"city":1095,"state":18,"zip":1096,"country":432,"countryCode":433,"cosmosGeoPoint":1097,"geoPoint":1101,"contacts":1102},"The James Cook University Hospital","Middlesbrough","TS4 3BW",{"type":54,"coordinates":1098},[1099,1100],-1.23483,54.57623,{"lat":1100,"lon":1099},[1103],{"name":1104,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Jeet Thambyrajah",{"facility":1106,"status":47,"city":1107,"state":18,"zip":1108,"country":432,"countryCode":433,"cosmosGeoPoint":1109,"geoPoint":1113,"contacts":1114},"Freeman Hospital","Newcastle upon Tyne","NE7 7DN",{"type":54,"coordinates":1110},[1111,1112],-1.61396,54.97328,{"lat":1112,"lon":1111},[1115],{"name":1116,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Vijay Kunadian",{"facility":1118,"status":47,"city":1119,"state":18,"zip":1120,"country":432,"countryCode":433,"cosmosGeoPoint":1121,"geoPoint":1125,"contacts":1126},"Kings Mill Hospital","Nottingham","NG17 4JL",{"type":54,"coordinates":1122},[1123,1124],-1.15047,52.9536,{"lat":1124,"lon":1123},[1127],{"name":1128,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Thandar Aye",{"facility":1130,"status":47,"city":1119,"state":18,"zip":1131,"country":432,"countryCode":433,"cosmosGeoPoint":1132,"geoPoint":1134,"contacts":1135},"Queens Medical Centre","NG7 2UH",{"type":54,"coordinates":1133},[1123,1124],{"lat":1124,"lon":1123},[1136],{"name":1137,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Michael Sosin",{"facility":1139,"status":47,"city":1140,"state":18,"zip":1141,"country":432,"countryCode":433,"cosmosGeoPoint":1142,"geoPoint":1146,"contacts":1147},"Royal Alexandra Hospital","Paisley","PA2 9PN",{"type":54,"coordinates":1143},[1144,1145],-4.43254,55.83173,{"lat":1145,"lon":1144},[1148],{"name":1149,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Stuart Hood",{"facility":1151,"status":47,"city":1152,"state":18,"zip":1153,"country":432,"countryCode":433,"cosmosGeoPoint":1154,"geoPoint":1158,"contacts":1159},"Derriford Hospital","Plymouth","PL6 8DH",{"type":54,"coordinates":1155},[1156,1157],-4.14305,50.37153,{"lat":1157,"lon":1156},[1160,1162],{"name":1161,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Sivasankar Sangaraju",{"name":1163,"role":38,"phone":18,"phoneExt":18,"email":18},"Mr Sanjay Asopa",{"facility":1165,"status":47,"city":1166,"state":18,"zip":1167,"country":432,"countryCode":433,"cosmosGeoPoint":1168,"geoPoint":1172,"contacts":1173},"Poole Hospital","Poole","BH15 2JB",{"type":54,"coordinates":1169},[1170,1171],-1.98458,50.71429,{"lat":1171,"lon":1170},[1174],{"name":1175,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Chris Steadman",{"facility":1177,"status":47,"city":1178,"state":18,"zip":1179,"country":432,"countryCode":433,"cosmosGeoPoint":1180,"geoPoint":1184,"contacts":1185},"Queen Alexandra Hospital","Portsmouth","PO6 3LY",{"type":54,"coordinates":1181},[1182,1183],-1.09125,50.79899,{"lat":1183,"lon":1182},[1186],{"name":1187,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Peter Haworth",{"facility":1189,"status":47,"city":1190,"state":18,"zip":1191,"country":432,"countryCode":433,"cosmosGeoPoint":1192,"geoPoint":1196,"contacts":1197},"Northern General Hospital","Sheffield","S5 7AU",{"type":54,"coordinates":1193},[1194,1195],-1.4659,53.38297,{"lat":1195,"lon":1194},[1198],{"name":1199,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Muhhammad Aetesam-ur-Rahman",{"facility":1201,"status":47,"city":1202,"state":18,"zip":1203,"country":432,"countryCode":433,"cosmosGeoPoint":1204,"geoPoint":1208,"contacts":1209},"Southampton General Hospital","Southampton","SO16 6YD",{"type":54,"coordinates":1205},[1206,1207],-1.40428,50.90395,{"lat":1207,"lon":1206},[1210,1212],{"name":1211,"role":38,"phone":18,"phoneExt":18,"email":18},"Professor Nick Curzen",{"name":1213,"role":38,"phone":18,"phoneExt":18,"email":18},"Mr Sunil Ohri",{"facility":1215,"status":47,"city":1216,"state":18,"zip":1217,"country":432,"countryCode":433,"cosmosGeoPoint":1218,"geoPoint":1222,"contacts":1223},"Forth Valley Royal Hospital","Stirling","FK9 4SW",{"type":54,"coordinates":1219},[1220,1221],-3.93682,56.11903,{"lat":1221,"lon":1220},[1224],{"name":1225,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Christopher Gingles",{"facility":1227,"status":47,"city":1228,"state":18,"zip":1229,"country":432,"countryCode":433,"cosmosGeoPoint":1230,"geoPoint":1234,"contacts":1235},"Stepping Hill Hospital","Stockport","SK2 7JE",{"type":54,"coordinates":1231},[1232,1233],-2.15761,53.40979,{"lat":1233,"lon":1232},[1236],{"name":1237,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Rosica Panayotova",{"facility":1239,"status":47,"city":1240,"state":18,"zip":1241,"country":432,"countryCode":433,"cosmosGeoPoint":1242,"geoPoint":1246,"contacts":1247},"North Tees and Hartlepool NHS Foundation Trust","Stockton-on-Tees","TS19 8PE",{"type":54,"coordinates":1243},[1244,1245],-1.3187,54.56848,{"lat":1245,"lon":1244},[1248],{"name":1249,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Paul Davison",{"facility":1251,"status":47,"city":1252,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":1253,"geoPoint":1257,"contacts":1258},"South Tyneside and Sunderland NHS Foundation Trust","Sunderland",{"type":54,"coordinates":1254},[1255,1256],-1.38222,54.90465,{"lat":1256,"lon":1255},[1259],{"name":1260,"role":38,"phone":18,"phoneExt":18,"email":18},"Samuel McClure",{"facility":1262,"status":47,"city":1263,"state":18,"zip":1264,"country":432,"countryCode":433,"cosmosGeoPoint":1265,"geoPoint":1269,"contacts":1270},"Torbay Hospital","Torquay","TQ2 7AA",{"type":54,"coordinates":1266},[1267,1268],-3.52522,50.46198,{"lat":1268,"lon":1267},[1271],{"name":1272,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Usman Sheikh",{"facility":1274,"status":47,"city":1275,"state":18,"zip":1276,"country":432,"countryCode":433,"cosmosGeoPoint":1277,"geoPoint":1281,"contacts":1282},"Royal Cornwall Hospital","Truro","TR1 3LJ",{"type":54,"coordinates":1278},[1279,1280],-5.05436,50.26526,{"lat":1280,"lon":1279},[1283],{"name":1284,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Mohammed Abubakr",{"facility":1286,"status":47,"city":1287,"state":18,"zip":1288,"country":432,"countryCode":433,"cosmosGeoPoint":1289,"geoPoint":1293,"contacts":1294},"Pinderfields Hospital","Wakefield","WF1 4DG",{"type":54,"coordinates":1290},[1291,1292],-1.49768,53.68331,{"lat":1292,"lon":1291},[1295],{"name":1296,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Thomas Craven",{"facility":1298,"status":47,"city":1299,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":1300,"geoPoint":1304,"contacts":1305},"South Warwickshire University NHS Foundation Trust","Warwick",{"type":54,"coordinates":1301},[1302,1303],-1.58333,52.28333,{"lat":1303,"lon":1302},[1306],{"name":1307,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr John Fryearson",{"facility":1309,"status":47,"city":1310,"state":18,"zip":1311,"country":432,"countryCode":433,"cosmosGeoPoint":1312,"geoPoint":1316,"contacts":1317},"Watford General Hospital","Watford","WD18 0HB",{"type":54,"coordinates":1313},[1314,1315],-0.39602,51.65531,{"lat":1315,"lon":1314},[1318],{"name":1319,"role":38,"phone":18,"phoneExt":18,"email":18},"Dr Piyush Jain",{"facility":1321,"status":47,"city":1322,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":1323,"geoPoint":1327,"contacts":1328},"New Cross Hospital","Wolverhampton",{"type":54,"coordinates":1324},[1325,1326],-2.12296,52.58547,{"lat":1326,"lon":1325},[1329],{"name":1330,"role":38,"phone":18,"phoneExt":18,"email":18},"Sandeep Hothi",{"facility":1332,"status":47,"city":1333,"state":18,"zip":18,"country":432,"countryCode":433,"cosmosGeoPoint":1334,"geoPoint":1338,"contacts":1339},"Worcester Acute Hospitals NHS FT","Worcester",{"type":54,"coordinates":1335},[1336,1337],-2.22001,52.18935,{"lat":1337,"lon":1336},[1340],{"name":1341,"role":38,"phone":18,"phoneExt":18,"email":18},"Ashiq Saffy",{"facility":1343,"status":457,"city":1344,"state":18,"zip":1345,"country":432,"countryCode":433,"cosmosGeoPoint":1346,"geoPoint":1350,"contacts":18},"Yeovil District Hospital","Yeovil","BA21 4AT",{"type":54,"coordinates":1347},[1348,1349],-2.63211,50.94159,{"lat":1349,"lon":1348},{"type":1352,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[1354,1356,1358],{"name":1355,"class":6},"University of Auckland, New Zealand",{"name":1357,"class":6},"University Hospitals, Leicester",{"name":31,"class":6},"100378235","the-early-valve-replacement-in-severe-asymptomatic-aortic-stenosis-study-100378235",false,"NCT04204915","The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study","A Randomised Controlled Trial of Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis","EASY-AS","Inclusion Criteria:\n\n1. Age \\>18 years\n2. Patient has severe asymptomatic AS, in line with current international guidelines, defined as either:\n\n   1. Peak velocity ≥4m\u002Fs OR mean pressure gradient ≥40mmHg WITH aortic valve area ≤1.0cm2 OR ≤0.6cm2\u002Fm2 body surface area OR\n   2. Peak velocity ≥4m\u002Fs OR mean pressure gradient ≥40mmHg WITH aortic valve area \\>1.0 - ≤1.2cm2 OR \\>0.6 - ≤0.7cm2\u002Fm2 body surface area AND high sex specific calcium score\\* OR\n   3. Peak Velocity ≥3.5m\u002Fs - 3.9m\u002Fs AND mean pressure gradient \\\u003C40 mmHg WITH aortic valve area ≤1.0cm2 OR ≤0.6cm2\u002Fm2 body surface area AND high sex specific calcium score\\* \\*Sex specific high calcium scores (Agatston units): \\>1200 females; \\>2000 males\n3. The responsible clinician feels that either ongoing surveillance or early AVR are appropriate.\n4. Regarded by the treating cardiologist to be suitable for AVR (surgical or TAVI) with an acceptable risk\n5. Willing to provide informed consent and be randomised to early AVR or expectant management\n6. An ability to understand one of the written languages that the study has provided written and visual materials in, or the availability of a translator to explain the study documentation\n\n   Exclusion Criteria:\n7. Symptoms related to AS\n8. Additional severe valvular heart disease\n9. Other cardiac surgery planned pre-randomisation (eg CABG)\n10. Left ventricular systolic dysfunction (LVEF \\\u003C50%)\n11. Pregnancy\n12. Co-morbid condition that, in the opinion of the treating cardiologist, limits life expectancy to \\\u003C2 years\n13. Patient has previously undergone AVR or TAVI with restenosis","ALL","18 Years",{"count":1370,"type":1371},2844,"ESTIMATED","INTERVENTIONAL",[1374],"NA","Aortic stenosis (AS) affects approximately 5% of individuals \\>65 years old, with \\~3% of people \\>75 years having moderate to severe disease. The prevalence of AS is rising rapidly due to an ageing population and is projected to double in the next two decades. Increasingly clinicians face the dilemma of how to best manage this growing population of mainly elderly patients, many of whom are asymptomatic but have been identified as having severe AS, often as an incidental finding. Reduced aortic valve opening progresses over decades without any apparent symptoms because the heart compensates for the AS. Ultimately, compensatory mechanisms fail resulting in angina, syncope or heart failure. If these symptomatic patients with severe AS remain untreated, they have a dire prognosis. In this situation the only effective treatment is AVR, either surgically or using TAVI. Conversely, conventional teaching and clinical practice in cardiology has been that, in the absence of symptoms, the prognosis is usually excellent and, except in a few very specific circumstances, conservative management and regular review (expectant management) is recommended. This advice is reflected in current international guidelines but is based largely on historical precedent. There has never been a randomised controlled trial to address the relative benefits of early AVR versus expectant management in patients with severe asymptomatic AS. The relative benefits of a strategy of early AVR\u002FTAVI versus expectant management in patients with asymptomatic severe AS are unclear. There is clinical equipoise but it remains one of the few areas of cardiovascular medicine where no randomised controlled trials (RCT) have been performed. The EASY-AS study will provide crucial data on the relative merits of these differing approaches to management, in terms of important patient orientated outcomes, conventional cardiovascular end-points and cost effectiveness.",[1377],"Aortic Stenosis",[1379,22,1380,1381,1382,1383],"Asymptomatic aortic stenosis","Randomised controlled trial","Expectant management","Hospitalisation for heart failure","Cardiovascular death","2025-09-24",{"date":1386,"type":1387},"2025-09-25","ACTUAL",{"date":1389,"type":1387},"2020-03-10",{"date":1391,"type":1371},"2031-04-01",{"name":5,"class":6},110]