[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590306":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":39,"responsibleParty":58,"collaborators":11,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":9,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":11,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":41,"whyStopped":11,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Exeter","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ProSauce","EXPERIMENTAL",null,[13],"Dietary Supplement: ProSauce",{"label":15,"type":16,"description":11,"interventionNames":17},"standard sauce","PLACEBO_COMPARATOR",[18],"Dietary Supplement: low-protein sauce",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"DIETARY_SUPPLEMENT","10g additional protein from ProSauce",[9],{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"low-protein sauce","Commercially available standard low-protein sauce",[15],[29],{"name":30,"affiliation":5,"role":31},"Joanna Bowtell, Prof","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},"Zhuoxiu Jin, Dr","CONTACT","+447529283410","z.jin3@exeter.ac.uk",{"name":30,"role":35,"phone":11,"phoneExt":11,"email":11},[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Exeter","Devon","EX44DZ","United Kingdom","UK",{"type":48,"coordinates":49},"Point",[50,51],-3.52751,50.7236,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":56,"phoneExt":11,"email":57},"Zhuoxiu Jin","07529283410","z.jin@lboro.ac.uk",{"type":59,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100590306","the-effect-of-a-plant-based-protein-dense-sauce-on-essential-amino-acid-concentrations-and-gut-fullness-in-older-adults-100590306",false,"NCT06965699","The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults","Testing the Effect of a Plant-based, Protein-dense Sauce (ProSauce) on Metabolic Availability of Essential Amino Acids and Gut Fullness and Satiety in Older Adults","Inclusion Criteria:\n\n* Aged 60 and over\n* Living independently in the community\n* Capacity to provide informed consent\n* Non-smoking (vaping is considered smoking)\n* No known medical conditions that might influence the study outcomes, e.g., heart disease, diabetes mellitus, obesity, disthyroidism and other endocrinopathies and renal failure\n* Not taking any medications that might influence the study outcomes e.g., taking anabolic steroids or corticosteroids long term\n* No clinically diagnosed eating disorders\n* No severe dislike or allergy to any of the study food\n* No hospitalisations in the last 6 months\n* Not dieting and weight stable for 3 months before the study (\\\u003C 3 kg change in weight)\n\nExclusion Criteria:\n\n* Age \\\u003C 60y\n* Smoking\n* Food allergies\n* Cognitive and mobility issues\n* Hospitalisation in the last 6 months\n* Known medical conditions that might influence the study outcomes\n* Taking medications that influence the study outcomes",true,"ALL","60 Years",{"count":71,"type":72},20,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (ProSauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein sauce without resulting in excessive gut fullness and satiety. The main questions it aims to answer are:\n\nDoes meals with high-protein sauce deliver better metabolic availability of amino acid profile? Does this high-protein sauce also not lead to excessive appetite suppression due to its liquid form? Researchers will compare high protein sauce to a commercially available standard low protein sauce.\n\nParticipants will consume two meals, either protein-fortified or standard low-protein sauce, in a randomised order with at least a one-week washout period between each meal. The investigators will collect venous blood samples over a 6-hour postprandial period to measure plasma essential (and non-essential) amino acid and insulin concentrations. The investigators will also measure appetite-related hormones from venous plasma and assess subjective appetite using a visual analogue scale, taken in parallel with the blood sample time points.",[78,79],"Malnutrition Elderly","Protein Malnutrition",[81,82,83,84],"plant-based protein sauce","older adults","amino acid metabolic availability","appetite regulation","2025-09-17",{"date":87,"type":88},"2025-09-23","ACTUAL",{"date":90,"type":88},"2025-07-10",{"date":92,"type":72},"2026-04-30",{"name":5,"class":6},1]