[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593630":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":24,"responsibleParty":28,"collaborators":24,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":21,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":24,"enrollmentInfo":41,"targetDuration":24,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":24,"overallStatus":50,"whyStopped":24,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":24},{"fullName":5,"class":6},"Ahi Evran University Education and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Balneotherapy group (group 1)","EXPERIMENTAL","Group 1 -Patients in the research group will receive geothermal treatment (spa therapy) for 20 minutes daily for 15 days.",[13],"Other: Balneotherapy",{"label":15,"type":6,"description":16,"interventionNames":17},"Control Group (group 2)","Group 2- Patients in the control group will be followed up with only a home exercise program",[18],"Other: home exercise program",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Balneotherapy","For balneotherapy, patients will be treated in a thermal pool for 15-20 minutes daily, with full-body immersion, for a total of 15 days.\n\nFor control, Volunteers in the control group will only receive a home exercise program. They will be called in for a check-up every five days to confirm that the home program is being followed correctly. In this way, the volunteers in the control group will not be left completely without treatment.",[9],null,{"type":6,"name":26,"description":26,"armGroupLabels":27,"otherNames":24},"home exercise program",[15],{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Figen Tuncay","Clinical Professor, Head of Physical Medicine and Rehabilitation","100593630","the-effect-of-balneotherapy-on-knee-osteoarthritis-100593630",false,"NCT07008937","The Effect of Balneotherapy on Knee Osteoarthritis","The Effect of Balneotherapy on the Inflammatory Process and Quality of Life in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Being over 50 years old\n* Patients diagnosed with knee OA\n* At stages 2-to-4 according to the Kellgren- Lawrence classification\n* Patients who agree to receive balneotherapy treatment\n\nExclusion Criteria:\n\n* Neoplasia\n* Infections\n* Uncompensated cardiac or pulmonary problems\n* Total knee arthroplasty\n* Inflammatory joint diseases (e.g., RA, AS)\n* Intra-articular injections in the past 6 months\n* Corticosteroids or anti-cytokine therapy\n* Patients with a BMI over 30 kg\u002Fm2","ALL","50 Years",{"count":42,"type":43},50,"ESTIMATED","INTERVENTIONAL",[46],"NA","Osteoarthritis (OA) is a chronic degenerative disease characterized by the breakdown and repair processes of the cartilage structure in synovial joints. Balneotherapy is one of the most commonly applied treatment methods in patients with OA. It is used to reduce pain and stiffness, improve joint mobility and quality of life, and prevent disease progression. Hyperthermia caused by balneotherapy activates the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis. After heat stress, HSp levels in the blood increase, triggering the HSp-cytokine-HPA-cortisol anti-inflammatory feedback mechanism, resulting in an anti-inflammatory effect and neuroendocrine immune regulation.\n\nIn various pathologies associated with low-grade inflammation-especially rheumatic diseases-balneotherapy and mud therapy have been reported to decrease serum concentrations of pro-inflammatory cytokines such as TNF-α and IL-1β. Serum COMP levels are elevated in OA patients. There is evidence that measuring COMP levels could serve as a prognostic marker for the development of OA in patients with chronic knee pain. It is evaluated not only as a cartilage marker but also as an indicator of synovial inflammation.\n\nThe aim of this study is to evaluate the response to inflammation and stress in patients with knee OA by examining the levels of CRP, IL-1 beta, COMP, and HSp following balneotherapy treatment. Additionally, changes in patients' quality of life and functional status after balneotherapy will also be evaluated.Fifty patients with primary osteoarthritis who meet the inclusion criteria and are receiving inpatient or outpatient treatment in the Physical Medicine and Rehabilitation clinic will be included in the study. It is planned to include 30 patients in the treatment group and 20 patients in the control group. Pain will be assessed using VAS, physical function and stiffness using WOMAC, and quality of life using the SF-36 scale. To determine the serum levels of COMP, IL-1 beta, CRP, and HSp70, blood samples will be collected under standard conditions from patients in a fasting state between 8:00-9:00 AM. Biochemical markers will be evaluated using ELISA kits.\n\nFor balneotherapy, patients will be treated in a thermal pool for 15-20 minutes daily, with full-body immersion, for a total of 15 days.",[49],"Osteoarthritis of Knee","NOT_YET_RECRUITING","2025-06-05",{"date":53,"type":54},"2025-06-06","ACTUAL",{"date":56,"type":43},"2025-07",{"date":58,"type":43},"2025-12",{"name":5,"class":6}]