[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606264":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":40,"responsibleParty":54,"collaborators":56,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"King Abdullah University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Opalescence","EXPERIMENTAL","Group 1: Opalescence XTra Boost 40% HP (OB) \\[Ultradent, Salt Lake, UT, USA\\] which will be used in a split-mouth design for a single application for 40 minutes and 2 applications for 20 minutes each.",[13],"Other: Opalescence XTra Boost 40% HP",{"label":15,"type":10,"description":16,"interventionNames":17},"PolaOffice","Group 2: Pola Office Plus 37.5% HP (PO) \\[SDI, Bayswater, Australia\\] which will be applied in a split-mouth design for a single 32 minutes and 4 applications of 8 min each",[18],"Other: Pola Office Plus 37.5% HP",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Opalescence XTra Boost 40% HP","In-office tooth bleaching material",[9],null,{"type":6,"name":26,"description":22,"armGroupLabels":27,"otherNames":24},"Pola Office Plus 37.5% HP",[15],[29],{"name":30,"affiliation":31,"role":32},"Ghada A Maghaireh","Jordan University of Science and Technology","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","0798809296","gmaghair@just.edu.jo",{"name":39,"role":35,"phone":24,"phoneExt":24,"email":24},"Ghada Maghaireh",[41],{"facility":31,"status":42,"city":43,"state":24,"zip":24,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Irbid","Jordan","JO",{"type":47,"coordinates":48},"Point",[49,50],35.85,32.55556,{"lat":50,"lon":49},[53],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},{"type":32,"investigatorFullName":39,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Principal Investigator",[57],{"name":31,"class":6},"100606264","the-effect-of-bleaching-application-mode-on-bleaching-induced-tooth-sensitivity-100606264",false,"NCT07173296","The Effect of Bleaching Application Mode on Bleaching-induced Tooth Sensitivity.","The Effect of Single and Multiple Application of In-office Dental Bleaching on Tooth Sensitivity and Bleaching Efficacy: a Single-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* At least eight maxillary anterior teeth present.\n* Age over 18\n* The selected teeth have a mean shade of C2 or darker.\n* Good general and oral health. (no visible plaque or gingivitis)\n* No restorations or carious lesions on the buccal surfaces of the anterior teeth to be whitened\n* No history of tooth sensitivity\n* No use of a desensitizing agent or desensitizing toothpaste in the past six months\n* No use of pain killer for the last 48 hours\n\nExclusion Criteria:\n\n* Active caries and\u002For periodontal diseases (gingivitis and recession) or wasting diseases\n* Smokers\n* Pregnant\u002Flactating women.\n* Patients who have bleached their teeth previously.\n* No schedule availability",true,"ALL","18 Years","35 Years",{"count":70,"type":71},60,"ESTIMATED","INTERVENTIONAL",[74],"NA","The aim of this study is to evaluate the effect of single versus multiple application protocols for in-office dental bleaching using two different bleaching gels (Pola Office Plus, SDI, 37.5% HP and Opalescence Boost, Ultradent, 40% HP) on the risk and intensity of tooth sensitivity, as well as the effect of the application protocol on the bleaching efficacy.\n\nNull hypothesis: There is no difference in intensity and risk of tooth sensitivity between single and multiple application of each gel and the application protocol dose not present significant effect on the bleaching efficacy.",[77],"Tooth Sensitivity",[79,80,81],"Sensitivity","Application mode","in-office bleaching","2025-09-07",{"date":84,"type":85},"2025-09-15","ACTUAL",{"date":87,"type":85},"2025-01-01",{"date":89,"type":71},"2026-09-30",{"name":5,"class":6},1]