[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603061":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":22,"locations":11,"responsibleParty":28,"collaborators":11,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":36,"acronym":37,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":11,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":51,"overallStatus":54,"whyStopped":11,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":11},{"fullName":5,"class":6},"Mersin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"intervention","EXPERIMENTAL",null,[13],"Other: cryocompression",{"label":15,"type":16,"description":11,"interventionNames":11},"control","NO_INTERVENTION",[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"cryocompression","Cryocompression induces vasoconstriction in the applied area, thereby reducing blood flow. As a result, the delivery of the chemotherapeutic agent to peripheral nerves is limited, and it is aimed to protect nerve tissue from toxic effects. At the same time, low temperature slows down nerve conduction and cellular metabolism, helping to prevent damage to nerve cells.\n\n30 minutes after the start of the paclitaxel infusion, cryocompression will be applied using ice gel gloves for the hands and socks for the feet, lasting 30 minutes. After paclitaxel ends, carboplatin will be infused intravenously in 250 cc isotonic solution over 1 hour. Cryocompression will again be applied 30 minutes after the start of the carboplatin infusion using the same method, for 30 minutes. This intervention will be performed weekly during each cycle of the 6-week carboplatin\u002Fpaclitaxel protocol, for a total of 60 minutes per session.",[9],[23],{"name":24,"role":25,"phone":26,"phoneExt":11,"email":27},"burcu okayer özer, MSc, PhD(c)","CONTACT","+905530520077","okayerb@gmail.com",{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","burcu okayer özer","MSc, PhD(c), Registered Nurse","100603061","the-effect-of-cryocompression-on-peripheral-neuropathy-in-patients-receiving-chemotherapy-for-gynecological-cancer-100603061",false,"NCT07131618","The Effect of Cryocompression on Peripheral Neuropathy in Patients Receiving Chemotherapy for Gynecological Cancer","CryoPN","Inclusion Criteria:\n\n* Applying to Mersin University Hospital Oncology Outpatient Clinic\n* Willing to participate and providing signed informed consent\n* Able to read and write in Turkish\n* Accessible and able to communicate\n* Citizen of the Republic of Türkiye\n* Diagnosed with gynecologic cancer (ovarian, endometrial, or cervical) and aged ≥18 years\n* Receiving weekly carboplatin + paclitaxel chemotherapy protocol\n* No subjective peripheral neuropathy symptoms before starting chemotherapy\n* No history of peripheral neuropathy related to previous taxane\u002Fplatinum-based chemotherapy protocols\n* No psychiatric disorders\n* No diseases that may cause peripheral neuropathy such as diabetes, rheumatoid arthritis, or fibromyalgia\n\nExclusion Criteria:\n\n* Not applying to the specified outpatient clinic\n* No gynecologic cancer diagnosis or younger than 18 years old\n* Not providing informed consent\n* Not receiving weekly carboplatin + paclitaxel chemotherapy protocol\n* Presence of subjective peripheral neuropathy symptoms before starting chemotherapy\n* History of peripheral neuropathy related to previous taxane\u002Fplatinum-based chemotherapy protocols\n* Presence of psychiatric disorders\n* Having diseases that may cause peripheral neuropathy such as diabetes, rheumatoid arthritis, or fibromyalgia","FEMALE","18 Years",{"count":42,"type":43},78,"ESTIMATED","INTERVENTIONAL",[46],"NA","Study Design:\n\nThis study is designed as a prospective, randomized controlled experimental study aiming to determine the effect of cryocompression therapy, applied during chemotherapy, on peripheral neuropathy symptoms in women with gynecologic cancers.\n\nResearch Hypotheses:\n\n* H₀: Cryocompression therapy has no effect on peripheral neuropathy.\n* H₁: Cryocompression therapy has an effect on peripheral neuropathy.\n\nStudy Population:\n\nThe study population will consist of women over the age of 18 living in Mersin, Türkiye, who are diagnosed with gynecologic cancer and undergoing chemotherapy between August 10 and December 31, 2025.",[49,50],"Gynecological Cancers","Peripheral Neuropathy Due to Chemotherapy",[52,19,53],"Gynecological cancer","peripheral neuropathy","NOT_YET_RECRUITING","2025-08-12",{"date":57,"type":58},"2025-08-20","ACTUAL",{"date":60,"type":43},"2025-08-10",{"date":62,"type":43},"2025-12-31",{"name":5,"class":6}]