[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592028":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":52,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":24,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":24,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Tokat Gaziosmanpasa University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sodium Hypochlorite, Wizard","ACTIVE_COMPARATOR","There are many studies in the literature showing that the use of 5.25% NaOCl as an enamel deproteinization agent is successful in positively affecting adhesion by removing organic elements from both the enamel structure and the pellicle on the enamel surface before acid application. However, sodium hypochlorite is a strong oxidizing agent and has disadvantages such as the risk of reaction in the soft tissues of the mouth, bad odor and bad taste, especially if not used carefully in pediatric dentistry, which has led to the search for an alternative material.",[13],"Other: application of deproteinization agents",{"label":15,"type":16,"description":17,"interventionNames":18},"Hypochlorous Acid, Superox","EXPERIMENTAL","Hypochlorous acid is produced by the body's immune system cells, neutrophilic polymorphonuclear leukocytes, as a result of oxidative reactions to overcome pathogenic microorganisms and fight infection. Recently, slightly acidic HOCl solutions, developed by electrolysis of NaOCl, have been widely used as disinfectants. Hypochlorous acid has been shown to significantly reduce the lipopolysaccharide concentration of Porphyromonas gingivalis compared to NaOCl and chlorhexidine and to be an agent tolerated by oral tissues. It has also been reported that HOCl used as a mouthwash does not produce any systemic side effects. In clinical dentistry, HOCl has been shown to be highly effective as a result of its antimicrobial and deproteinizing properties. HOCl, with its low acidity, is an antiseptic irrigant with extraordinary properties, not only exhibiting biocompatibility and low cytotoxicity, but also having rapid and highly effective antimicrobial activity in physiological concentration rang",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"application of deproteinization agents","Since there is no in vivo study in the literature evaluating the clinical success of the use of hypochlorous acid for deproteinization in fissure sealants, our planned study is the first in this regard.",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Alem Coşgun","CONTACT","+905524133222","alemcosgun@hotmail.com",[32],{"facility":33,"status":34,"city":35,"state":24,"zip":36,"country":37,"countryCode":24,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Tokat Gaziosmanpaşa University","RECRUITING","Tokat Province","60030","Turkey (Türkiye)",{"type":39,"coordinates":40},"Point",[41,42],36.55444,40.31389,{"lat":42,"lon":41},[45,47,49],{"name":27,"role":28,"phone":46,"phoneExt":24,"email":30},"05524133222",{"name":27,"role":48,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"name":50,"role":51,"phone":24,"phoneExt":24,"email":24},"Merve Tatar","SUB_INVESTIGATOR",{"type":48,"investigatorFullName":27,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Asistant proffessor","100592028","the-effect-of-different-deproteinising-agents-on-the-clinical-success-of-fissure-sealants-in-permanent-teeth-100592028",false,"NCT06988098","The Effect of Different Deproteinising Agents on the Clinical Success of Fissure Sealants in Permanent Teeth","Evaluation of the Effect of Different Deproteinizing Agents on the Clinical Success of Fissure Sealants in Permanent Teeth: Splint Mouth Clinical Study","Inclusion Criteria:\n\n* Patients between the ages of 6-9 who do not have any systemic problems\n* Have a score of 3 and 4 on the Frankl Behavior Scale\n* Do not have a habit of clenching and\u002For grinding their teeth\n* Have newly erupted permanent lower first molars without caries\n* Have an indication for fissure sealant application\n\nExclusion Criteria:\n\n* Teeth with fissure sealants\n* Teeth with developmental defects such as hypoplasia\n* Teeth with approximal or incipient caries lesions on one or both mandibular first permanent molars\n* Children who are not systemically healthy\n* Uncooperative children with scores of 1 and 2 on the Frankl Behavior Scale\n* Children and parents who refuse to attend follow-up appointments\n* Children with parafunctional habits such as teeth grinding",true,"ALL","6 Years","9 Years",{"count":66,"type":67},60,"ESTIMATED","INTERVENTIONAL",[70],"NA","Investigation of the effect of deproteinization agents on the clinical success of non-invasive fissure sealant application, which is a non-invasive method used to prevent caries formation or to stop the progression of initial caries lesions limited to enamel on tooth surfaces thought to be at high risk of caries.",[73],"Fissure Sealant",[75,76,77,78],"Deproteinization Agents","Sodium Hypochlorite","Hypochlorous Acid","fissure sealent","2025-05-16",{"date":81,"type":82},"2025-05-23","ACTUAL",{"date":84,"type":82},"2024-08-01",{"date":86,"type":67},"2027-08-01",{"name":5,"class":6},1]