[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100438495":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":64,"collaborators":24,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":24,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":24,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":24,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"American University of Beirut Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mediterranean Diet","EXPERIMENTAL","30 participants will be randomized to this arm. The intervention consists of 8 visits, over a period of 24 weeks, including 6 individual educational sessions on Mediterranean diet in patients on Semaglutide and 2 reinforcement educational sessions towards the end of the trial. Dietary assessments and adherence questionnaires will be conducted on several visits to assess adherence.",[13],"Other: Dietary Intervention Med Diet",{"label":15,"type":10,"description":16,"interventionNames":17},"High Protein\u002FLow Carbohydrate Diet","30 participants will be randomized to this arm. The intervention consists of 8 visits, over a period of 24 weeks, including 6 individual educational sessions on High Protein\u002FLow Carbohydrate diet in patients on Semaglutide and 2 reinforcement educational sessions towards the end of the trial. Dietary assessments and adherence questionnaires will be conducted on several visits to assess adherence.",[18],"Other: Dietary Intervention HP\u002FLC Diet",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Dietary Intervention Med Diet","The diet will consist of a calorie-restricted Med diet, with 500 Kcal\u002Fd energy restriction. The intervention consists of individual and reinforcement sessions on Med diet. During these sessions, the RA will go over the benefits of Med diet, what composition it should have, and how to make appropriate choices for meal planning, in addition to providing food lists, by season. The individual sessions with subjects will also allow to individualize the diet plan.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Dietary Intervention HP\u002FLC Diet","This is a non-ketogenic diet consisting of ad libitum intake of proteins, fat, and vegetables, with restriction of daily carbohydrates to \\\u003C130 g\u002Fd. The intervention consists of individual and reinforcement educational sessions on HP\u002FLC, same as with Med diet (above). The individual sessions with subjects will also allow to individualize the diet plan.",[15],[30],{"name":31,"affiliation":5,"role":32},"Marlene Chakhtoura, MD, MSc","PRINCIPAL_INVESTIGATOR",[34,39],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","+9611350000","7411","mc39@aub.edu.lb",{"name":40,"role":35,"phone":36,"phoneExt":41,"email":42},"Rachelle El Haber, BSc","8314","re136@aub.edu.lb",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"American University of Beirut - Medical Center","RECRUITING","Beirut","Riad El Solh","1107 2020","Lebanon","LB",{"type":53,"coordinates":54},"Point",[55,56],35.50157,33.89332,{"lat":56,"lon":55},[59,63],{"name":60,"role":35,"phone":61,"phoneExt":24,"email":62},"AUBMC","+961350000","aubmc@aub.edu.lb",{"name":31,"role":32,"phone":24,"phoneExt":24,"email":24},{"type":32,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Marlene Chakhtoura","Assistant Professor of Medicine","100438495","the-effect-of-different-diets-on-arterial-stiffness-in-obese-patients-on-semaglutide-100438495",false,"NCT04990024","The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide","The Effect of Mediterranean or High Protein\u002FLow Carbohydrate Diet on Arterial Stiffness in Non-diabetic, Obese Patients on Semaglutide: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Men and premenopausal women, 18-49 years, with obesity defined as BMI ≥ 30 kg\u002Fm2\n* Upon the initiation of Semaglutide (within the first 1-4 weeks) for medical weight management, for clinical purposes, as advised by the primary physician\n* Able to commit for a 6-month trial visits\n\nExclusion Criteria:\n\n* Pregnant women\n* Patients who are taking or have taken other weight reducing drug therapies in the previous 6 months\n* Patients who have undergone metabolic weight loss surgery\n* Patients known to have diabetes (HbA1c ≥6.5% at screening)\n* Patients with uncontrolled hypertension\n* Patients with uncontrolled cardiac disease, pulmonary, renal or liver diseases, active cancer or psychiatric diseases\n* Patients with excessive alcohol intake, defined as ≥ 2 glasses per day\n* Patients known to have uncontrolled\u002F untreated thyroid disorders.\n* Patients with cushing disease or polycystic ovaries, and those with neuro-endocrine or drug induced obesity (such as anti-psychotic, steroids, hormonal therapy): Such patients are resistant to weight loss, and they need treatment of their primary disease and\u002For cessation of the culprit medication to lose weight\n* Patients with untreated gout\n* Patients who have undergone bariatric surgery",true,"ALL","18 Years","49 Years",{"count":79,"type":80},60,"ESTIMATED","INTERVENTIONAL",[83],"NA","In patients initiating Semaglutide for weight management, the objective is to compare the effect of the Mediterranean diet and the high protein\u002Flow carbohydrate (HP\u002FLC) diet CV parameters, namely arterial stiffness, measured by carotid-femoral pulse wave velocity (cfPWV), and visceral adipose tissue, in addition to other metabolic indicators.",[86,87],"Obesity","Weight Loss","2024-08-03",{"date":90,"type":91},"2024-08-06","ACTUAL",{"date":93,"type":91},"2021-07-01",{"date":95,"type":80},"2025-09-15",{"name":5,"class":6},1]