[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580987":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":37,"centralContacts":42,"locations":49,"responsibleParty":69,"collaborators":10,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":10,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":10,"enrollmentInfo":81,"targetDuration":84,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":10,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Semmelweis University","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"direct pulp capping",null,"After local anaesthesia the tooth is absolutely isolated. The coronal part of the tooth is then disinfected with a cotton pellet soaked in 5% sodium hypochlorite. Under an operating microscope, the caries is removed non-selectively towards the pulpal wall. The absence of caries on non-pulpal walls is confirmed by caries indicator. The pulp chamber is opened with a sterile diamond bur in a turbine with copious water cooling. After opening the pulp gentle pressure of a sterile cotton pellet soaked in 2.5% NaOCl is applied to the exposed pulp to achieve hemostasis.",[13,14],"Procedure: with Biodentine","Procedure: with MTA",{"label":16,"type":10,"description":17,"interventionNames":18},"partial pulpotomy","After local anaesthesia the tooth is absolutely isolated. The coronal part of the tooth is then disinfected with a cotton pellet soaked in 5% sodium hypochlorite. Under an operating microscope, the caries is removed non-selectively towards the pulpal wall. The absence of caries on non-pulpal walls is confirmed by caries indicator. The pulp chamber is opened with a sterile diamond bur in a turbine with copious water cooling. After opening of the pulp with a sterile diamond bur, an additional 2-3 mm of coronal pulp tissue is removed with copious water cooling. Subsequently, light pressure is applied to the pulp for 5 minutes with a cotton pellet dipped in 2.5% NaOCl to control bleeding.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"complete pulpotomy","After local anaesthesia the tooth is absolutely isolated. The coronal part of the tooth is then disinfected with a cotton pellet soaked in 5% sodium hypochlorite. Under an operating microscope, the caries is removed non-selectively towards the pulpal wall. The absence of caries on non-pulpal walls is confirmed by caries indicator. After the coronal pulp tissue is removed down to the level of the orifices using a sterile diamond bur with copious water cooling. Bleeding is controlled by gentle pressure with a cotton pellet soaked in 2.5% NaOCl.",[13,14],[24,31],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","with Biodentine","After the bleeding has stopped, the cavity is flushed with sterile saline and Biodentine (Septodont, Saint-Maur-des-Fossés, France) is mixed according to the manufacturer's instructions. First it is applied directly to the pulp wound using light pressure, and then the entire cavity is filled with it. One week later the superficial 2-3 mm is removed and replaced it with permanent restoration.",[20,9,16],[30],"Biodentine, Septodont",{"type":25,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"with MTA","After the bleeding has stopped, the cavity is flushed with sterile saline and MTA+ (Cercamed, Stalowa Wola, Poland) is mixed according to the manufacturer's instructions. First it is applied directly to the pulp wound using light pressure, and after its initial setting the cavity is filled with glass ionomer cement. One week later the glass ionomer cement is removed and replaced it with permanent restoration.",[20,9,16],[36],"MTA +, Cercamed",[38],{"name":39,"affiliation":40,"role":41},"János Vág, DMD, PhD","Semmewleis University, Department of Restorative Dentistry and Endodontics","STUDY_CHAIR",[43],{"name":44,"role":45,"phone":46,"phoneExt":47,"email":48},"Melinda Zs Polyák, DMD","CONTACT","+36 1 459 1500","59371","polyak.melinda@semmelweis.hu",[50],{"facility":51,"status":52,"city":53,"state":10,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Department for Restorative Dentistry and Endodontics, Semmelweis University","RECRUITING","Budapest","1088","Hungary","HU",{"type":58,"coordinates":59},"Point",[60,61],19.04045,47.49835,{"lat":61,"lon":60},[64,67],{"name":39,"role":45,"phone":65,"phoneExt":10,"email":66},"+36209577245","vag.janos@semmelweis.hu",{"name":44,"role":68,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":68,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dr. Vag Janos","Professor","100580987","the-effect-of-different-risk-factors-on-the-success-rate-of-vpt-100580987",false,"NCT06844448","The Effect of Different Risk Factors on the Success Rate of VPT","The Effect of Different Risk Factors on the Success Rate of VPT: an Observational Prospective Cohort Study","Inclusion Criteria:\n\n* Patients over 18 years of age who have at least one tooth with a pulp chamber that has been opened during a dental procedure or is likely to be opened during restoration of the tooth\n* The tooth is responsive to a sensitivity test with cold spray\n* The coronal part must be restorable\n* The periodontal depth around the tooth should be 0 according to the Dental Practicality Index Periodontal Treatment Need, i.e. the probing depth around the tooth should not be greater than 3.5 mm\n\nExclusion Criteria:\n\n* Internal\u002Fexternal resorption in the tooth\n* If the root development of the tooth is not yet complete or if it is a deciduous tooth\n* Absolute isolation cannot be performed during the procedure\n* If pulp exposure does not occur even after complete removal of caries\n* The crown of the tooth cannot be restored\n* Periodontium surrounding tooth affected by moderate\u002Fsevere marginal periodontitis (probing depth deeper than 3.5 mm)\n* Pulp exposure due to traumatic injury\n* Baseline radiograph shows signs of severe pulp palcification\n* Periapical lesion is around the root (Periapical index of the tooth \\>2)","ALL","18 Years",{"count":82,"type":83},400,"ESTIMATED","4 Years","OBSERVATIONAL","This study aims to evaluate the effectiveness of various vital pulp therapy (VPT) methods, such as direct pulp capping, partial pulpotomy, and total pulpotomy, in maintaining pulp vitality following pulp exposure. It explores the success rates of these treatments compared and investigates co-factors influencing these rates, including age. This prospective cohort study involves patients over 18 with restorable teeth and exposed pulp chambers. Success is measured through clinical and radiological criteria over a follow-up period of up to four years. The study also aims to identify if there's an age threshold affecting the preference for VPT over root canal therapy.",[88,89,90,91,92],"Dental Caries Extending to Pulp","Pulp Disease, Dental","Irreversible Pulpitis","Reversible Pulpitis","Pulpitis","2025-03-03",{"date":95,"type":96},"2025-03-06","ACTUAL",{"date":98,"type":96},"2024-06-01",{"date":100,"type":83},"2030-06-01",{"name":5,"class":6},1]