[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618088":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":58,"collaborators":62,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":30,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":30,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":91,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Kirsehir Ahi Evran Universitesi","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"high-intensity exercise","EXPERIMENTAL","Patients in this group will receive information and education about their condition and will be instructed to continue their current medical treatment and attend follow-up appointments regularly. Additionally, this group will undergo a high-intensity interval training (HIIT) program with a physiotherapist for 40 sessions in total, 5 sessions per week for 8 weeks, each lasting 35 minutes. Patients will work at 80% to 100% of their maximum heart rate. The first 4 weeks will be at 80% of maximum heart rate, followed by 85%, 90%, 95%, and finally 100%. This protocol will consist of 4 active periods of 4 minutes each at 80% to 100% of maximum heart rate (percentage to be determined weekly) and 3 rest periods of 3 minutes each at 60-70% of maximum heart rate (4x4 minutes). Each session will include a 5-minute warm-up before HIIT and a 5-minute cool-down after HIIT, for a total exercise time of 35 minutes.",[13],"Other: High-Intensity Interval Training",{"label":15,"type":10,"description":16,"interventionNames":17},"moderate intensity exercise","Patients in this group will receive information and education about their condition and will be instructed to continue their current medical treatment and attend regular follow-up appointments. Additionally, these patients will undergo a 40-minute, 5-session, 40-minute moderate-intensity continuous exercise (MCIT) program with a physiotherapist over 8 weeks. Patients will exercise at 50-70% of their maximum heart rate and with an RPE of 11-13 for 30 minutes. Each session will include a 5-minute warm-up before MCIT and a 5-minute cool-down after MCIT, for a total exercise duration of 40 minutes.",[18],"Other: Moderate-Intensity Continuous Exercise",{"label":20,"type":21,"description":22,"interventionNames":23},"control","ACTIVE_COMPARATOR","Patients in this group will receive information and education about their illness and will be advised to continue their current medical treatment and attend their follow-up appointments regularly.",[24],"Other: control group",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"High-Intensity Interval Training","Patients will be trained at 80% to 100% of their maximum heart rate. For the first 4 weeks, they will train at 80% of their maximum heart rate, then at 85%, 90%, 95%, and finally 100%. This protocol will consist of 4 active periods of 4 minutes each at 80% to 100% of maximum heart rate (percentage to be determined weekly) and 3 rest periods of 3 minutes each at 60-70% of maximum heart rate (4x4 minutes). Each session will include a 5-minute warm-up before HIIT and a 5-minute cool-down after HIIT, for a total exercise time of 35 minutes.",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Moderate-Intensity Continuous Exercise","Patients will be trained for 30 minutes at 50% to 70% of their maximum heart rate and with an RPE of 11-13. Each session will include a 5-minute warm-up before MCIT and a 5-minute cool-down after MCIT, for a total exercise time of 40 minutes.",[15],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"control group","They will be given information and education about their illnesses and will be advised to continue their current medical treatment and attend their follow-up appointments regularly.",[20],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Nazife Kapan Tunçer Asst. Prof.","CONTACT","+905555839701","nazifekapan@gmail.com",[46],{"facility":47,"status":30,"city":48,"state":30,"zip":30,"country":49,"countryCode":30,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Kırşehir Ahi Evran Üniversitesi","Kırşehir","Turkey (Türkiye)",{"type":51,"coordinates":52},"Point",[53,54],34.16389,39.14583,{"lat":54,"lon":53},[57],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Nazife Kapan","Asst. Prof.",[63],{"name":64,"class":65},"Scientific Research Projects","AMBIG","100618088","the-effect-of-exercise-on-serum-irisin-levels-and-clinical-parameters-in-patients-with-axial-spondyloarthritis-100618088",false,"NCT07327073","The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.","The Effect of High-intensity Intermittent Exercise and Moderate-intensity Continuous Exercise on Serum Irisin Levels, Disease Activity, Functional Status, and Quality of Life in Patients With Axial Spondyloarthritis: a Prospective, Randomized Study","Inclusion Criteria:\n\n* Patients diagnosed with axillary spondyloarthropathy according to ASAS diagnostic criteria,\n* Having a high disease severity (ASDAS-CRP above 2.1),\n* Being sedentary (not engaging in physical activity at least 3 days a week in the last 3 months),\n* Having no change in ankylosing spondylitis medical treatment in the last 3 months,\n* Not having any orthopedic, neurological, cardiovascular, or mental disease that would affect exercise,\n* Not using any assistive devices for ambulation,\n* Having a BMI of 25 kg\u002Fm2 or less,\n* Male and female patients aged 18-50 years.\n\nExclusion Criteria:\n\n* Those with uncontrolled cardiopulmonary disease (such as hypertension, chronic obstructive pulmonary disease, heart failure),\n* Having comorbidities that reduce exercise capacity,\n* Pregnancy,\n* Malignancy,\n* Those with a recent history of surgery,\n* Those who have engaged in regular exercise (aquatic exercise, land exercise, etc.) in the previous 3 months",true,"ALL","18 Years","50 Years",{"count":78,"type":79},75,"ESTIMATED","INTERVENTIONAL",[82],"NA","This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with axial spondyloarthritis.",[85,86],"Ankylosing Spondylitis (AS)","Irisin",[88,89,90],"ankylosing spondylitis","exercise","irisin","NOT_YET_RECRUITING","2026-01-09",{"date":94,"type":95},"2026-01-12","ACTUAL",{"date":97,"type":79},"2026-01-30",{"date":99,"type":79},"2026-05-30",{"name":5,"class":6},1]