[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617609":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":49,"locations":60,"responsibleParty":81,"collaborators":18,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":18,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":18,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":109,"overallStatus":63,"whyStopped":18,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Standart Pulmonary Rehabilitation Group (SGr)","ACTIVE_COMPARATOR","In the SGr program, exercises are planned to be performed under the supervision of a remote physiotherapist, 2 days a week with the telerehabilitation method and 1 day as a home- based program by the patient. The exercise program includes aerobic, resistance exercises and respiratory exercises, and patients are followed for 3 months.",[13],"Behavioral: Standard pulmonary rehabilitation programme",{"label":15,"type":16,"description":17,"interventionNames":18},"Pulmonary Rehabilitation Group with Inspiratory Muscle Training (IGr)","EXPERIMENTAL","In the IGr program, exercises are planned under the supervision of a remote physiotherapist, with the telerehabilitation method 2 days a week and with a program to be done by the patient at home 1 day a week. The exercise program includes aerobics, resistance exercises, respiratory exercises and respiratory muscle strengthening training with a resistive thereshold inspiratory muscle strengthening device, and patients are followed for 3 months.",null,{"label":20,"type":6,"description":21,"interventionNames":22},"Control Group (CGr)","The KGr group will consist of women and men aged between 18-75, who have signed the informed consent form regarding the study, have a BMI \\\u003C30, are non-smokers, have no known systemic disease, and have FEV1\\>80, and are age and gender matched to the exercise groups.",[23],"Other: No intervention",[25,30,34],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":18},"BEHAVIORAL","Standard pulmonary rehabilitation programme","Patients are asked to perform thoracic, diaphragmatic breathing, and lower basal breathing exercises with 10 repetitions. Then, strengthening exercises are performed on the major muscle groups of the upper and lower extremities. In accordance with the resistance training program in the ATS\u002FERS guidelines for pulmonary rehabilitation, two to four sets of 6-12 repetitions are performed with intensities ranging from 50% to 85% of one maximum repetition, two to three times a week. During the exercises, the patient is questioned about their fatigue and dyspnea levels using the Borg scale, and breaks are given when necessary. The aerobic exercise program is performed as a 12-week, 3-day-a-week self-walking exercise. The walking program is performed in the form of walking on flat ground at 60% workload, based on the data obtained from the 6-minute walking test result (land-based walking).",[9],{"type":31,"name":32,"description":33,"armGroupLabels":18,"otherNames":18},"DEVICE","Resistive threshold inspiratory muscle training","In the other arm of the study, respiratory muscle training is performed in addition to the \"standard pulmonary rehabilitation program.\" Respiratory muscle strengthening training is performed with a resistive thereshold inspiratory muscle strengthening device. The exercise is performed at an intensity of 30% of the maximum inspiratory pressure determined by mouth pressure measurement. The exercise is performed in 7 sets, with 2 minutes of work and 1 minute break for a total of 21 minutes.",{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":18},"No intervention","Peripheral blood samples will be taken once from the participants in the control group and no other intervention will be performed.",[20],[39,42,46],{"name":40,"affiliation":5,"role":41},"Esra PEHLİVAN, Assoc. Prof.","STUDY_CHAIR",{"name":43,"affiliation":44,"role":45},"Erdoğan ÇETİNKAYA, Prof. Dr.","Yedikule Chest Diseases And Thoracic Surgery Training And Research Hospital","STUDY_DIRECTOR",{"name":47,"affiliation":5,"role":48},"Zeynep Betül ÖZCAN, PhD (c)","PRINCIPAL_INVESTIGATOR",[50,56],{"name":51,"role":52,"phone":53,"phoneExt":54,"email":55},"Zeynep Betül ÖZCAN","CONTACT","+90 216 346 36 36","2010- 2011","zbetulozcan@gmail.com",{"name":57,"role":52,"phone":53,"phoneExt":58,"email":59},"Esra PEHLİVAN","2010-2011","esra.pehlivan@sbu.edu.tr",[61],{"facility":62,"status":63,"city":64,"state":65,"zip":18,"country":66,"countryCode":18,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"University of Health Sciences","RECRUITING","Istanbul","Turkey","Turkey (Türkiye)",{"type":68,"coordinates":69},"Point",[70,71],28.94966,41.01384,{"lat":71,"lon":70},[74,77,80],{"name":75,"role":52,"phone":53,"phoneExt":76,"email":59},"Esra PEHLİVAN, Assos. Prof.","2010 - 2011",{"name":43,"role":52,"phone":78,"phoneExt":76,"email":79},"Telephone: +90 216 346 36 36","erdogan.cetinkaya@sbu.edu.tr",{"name":47,"role":48,"phone":18,"phoneExt":18,"email":18},{"type":48,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Zeynep Betül Özcan","Principal Investigator","100617609","the-effect-of-exercise-training-on-lncrna-expression-in-rheumatoid-arthritis-100617609",false,"NCT07320846","The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis","Investigation of the Effects of Standard Rehabilitation Program and Inspiratory Muscle Training on lncRNA HOTAIR Expression in Patients With Rheumatoid Arthritis","Inclusion Criteria:\n\n* Diagnosed with RA according to the ACR\u002FEULAR 2010 classification criteria\n* Duration of diagnosis greater than 2 years\n* Disease activity with a DAS28 score below 5.1\n* Voluntary participation in the study\n* Presence of lung involvement\n\nExclusion Criteria:\n\n* Having orthopedic deformities that may affect the treatment program\n* Pregnancy\n* Uncontrolled diabetes or heart disease\n* Participation in a rehabilitation program within the last 6 months\n* Body Mass Index (BMI) \\> 30\n* Patients with severe organ failure\n* Recent acute coronary syndrome\n* Presence of active infection",true,"ALL","18 Years","75 Years",{"count":96,"type":97},39,"ESTIMATED","INTERVENTIONAL",[100],"NA","The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid arthritis-associated interstitial lung disease. The main questions it aims to answer are:\n\n* Does respiratory muscle strengthening exercise added to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength?\n* Does the gain obtained with respiratory muscle strengthening iin patients with rheumatoid arthritis-associated interstitial lung disease increase the quality of life of patients and have a positive effect on their psychological state?\n* Does respiratory rehabilitation applied to iin patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes?\n* Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes?\n* Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post- treatment rehabilitation criteria and genetic changes will be compared.",[103,104,105,106,107,108],"Exercise","Pulmonary Rehabilitation","Interstitial Lung Disease","Long Noncoding RNA","Inspiratory Muscle Training","Rheumatoid Arthritis",[110,111,112,113,114,115],"inspiratory muscle training","long noncoding RNA","exercise","pulmonary rehabilitation","Interstitial lung disease","rheumatoid arthritis","2025-12-27",{"date":118,"type":119},"2026-01-06","ACTUAL",{"date":121,"type":119},"2024-05-18",{"date":123,"type":97},"2026-03-12",{"name":5,"class":6},1]