[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633383":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":40,"studyPopulation":29,"armGroups":41,"interventions":52,"overallOfficials":58,"centralContacts":62,"locations":71,"responsibleParty":87,"collaborators":29,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":29,"eligibilityCriteria":95,"healthyVolunteers":91,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":29,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":74,"whyStopped":29,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Pardis Specialized Wellness Institute","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":29},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Change in physical function","Assessed with the 6-Minute Walk Test. Greater distance indicates better physical function and walking endurance.","Baseline and 8 weeks",{"measure":14,"description":15,"timeFrame":12},"Change in dynamic balance","Assessed with the Mini-BESTest total score. Higher scores indicate better dynamic balance and postural control.",{"measure":17,"description":18,"timeFrame":12},"Change in fall-related concern","Assessed with the Falls Efficacy Scale-International (FES-I). Higher scores indicate greater concern about falling.",[20,23,26],{"measure":21,"description":22,"timeFrame":12},"Change in functional mobility","Assessed with the Timed Up and Go test. Shorter completion times indicate better mobility.",{"measure":24,"description":25,"timeFrame":12},"Change in gait speed","Assessed with the 10-Meter Walk Test. Faster walking speed indicates better gait performance.",{"measure":27,"description":28,"timeFrame":12},"Change in lower-limb functional strength","Assessed with the 30-second sit-to-stand test. More repetitions indicate better lower-limb functional strength and endurance.",null,{"allocation":31,"interventionModel":32,"interventionModelDescription":33,"primaryPurpose":34,"observationalModel":29,"timePerspective":29,"maskingInfo":35},"RANDOMIZED","PARALLEL","Participants will be randomly allocated to intervention group or control group and will be examined in the same way.","TREATMENT",{"masking":36,"maskingDescription":37,"whoMasked":38},"SINGLE","A research project collaborator who is not informed about grouping of participants will obtain outcome measurements of the functional tests. Outcome adjudicators and data analysts will be kept blinded to the allocation. Moreover, all investigators, staff, and participants will be kept masked to outcome measurements and trial results.",[39],"OUTCOMES_ASSESSOR","Parkinson's disease is a progressive neurodegenerative disorder characterized not only by tremor and bradykinesia, but also by impaired gait, postural instability, reduced turning ability, slowed mobility, and increased fear of falling. These impairments are major contributors to functional limitation, reduced independence, and decreased quality of life in people with Parkinson's disease. Recent systematic reviews and network meta-analyses have demonstrated that exercise interventions can improve physical function, balance, gait performance, and mobility-related outcomes in this population. However, balance impairment and falls remain highly prevalent despite conventional rehabilitation approaches, highlighting the need for additional targeted non-pharmacological interventions.\n\nVisual and oculomotor dysfunction are increasingly recognized as clinically relevant features of Parkinson's disease. Abnormalities in saccadic eye movements, smooth pursuit, gaze stabilization, and visuomotor control have been reported in patients with Parkinson's disease and may contribute to impaired postural control, gait dysfunction, and difficulties with movement coordination. Recent studies in neurorehabilitation and eye-movement research suggest that eye exercises and visually guided training may positively influence balance control, mobility, and motor-related performance by enhancing sensory integration and visuomotor coordination.\n\nEmerging rehabilitation studies have reported promising effects of structured eye-movement interventions on dynamic balance, walking performance, and functional mobility in individuals with Parkinson's disease. In addition, recent advances in eye-tracking and oculomotor assessment research further support the potential therapeutic relevance of visually guided interventions in Parkinson's disease rehabilitation. Nevertheless, high-quality randomized controlled trials investigating supervised eye-exercise programs in clinical settings remain limited.\n\nTherefore, the present study will investigate the effects of a structured supervised in-center eye-exercise program on physical function, dynamic balance, and fall-related concern in patients with Parkinson's disease. The intervention will be delivered face-to-face in a controlled rehabilitation setting to enhance safety, standardization, treatment fidelity, and adherence. By focusing on clinically meaningful functional outcomes, this trial aims to determine whether supervised eye exercises may represent a practical and effective adjunct rehabilitation strategy for improving mobility- and balance-related outcomes in people with Parkinson's disease.",[42,48],{"label":43,"type":44,"description":45,"interventionNames":46},"Supervised In-Center Eye Exercise Group","EXPERIMENTAL","Participants will receive a structured eye-exercise program designed to train oculomotor control, gaze stability, and eye-head coordination. The program will be delivered face-to-face in the center during supervised sessions. Each session will last approximately 30 to 45 minutes, 3 sessions per week for 8 weeks.",[47],"Behavioral: Supervised In-Center Eye Exercises",{"label":49,"type":50,"description":51,"interventionNames":29},"Control group","NO_INTERVENTION","Participants allocated to the control arm will receive standard neurological care and routine advice to maintain their usual daily activities. They will not receive the structured eye-exercise program during the intervention period.",[53],{"type":54,"name":55,"description":56,"armGroupLabels":57,"otherNames":29},"BEHAVIORAL","Supervised In-Center Eye Exercises","The participants in the study group will perform the eye-exercise program in a supervised rehabilitation\u002Fclinic setting. The exercises will initially be performed in a seated position, with selected tasks progressed to standing positions as tolerated and considered safe by the supervising therapist. The exercises will be administered face-to-face by trained study personnel. The program will include progressive visual fixation, smooth pursuit, saccadic eye movements, convergence\u002Fdivergence, gaze stabilization, and combined eye-head coordination tasks, with gradual progression in speed and complexity according to participant tolerance and safety.",[43],[59],{"name":60,"affiliation":5,"role":61},"Mohammad Ali Tabibi, Dr","STUDY_DIRECTOR",[63,68],{"name":64,"role":65,"phone":66,"phoneExt":29,"email":67},"Nasrin Salimian","CONTACT","+989132-51202","statisrin@gmail.com",{"name":60,"role":65,"phone":69,"phoneExt":29,"email":70},"+989133184624","m.tabibi@ut.ac.ir",[72],{"facility":73,"status":74,"city":75,"state":29,"zip":29,"country":76,"countryCode":77,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"Pardis specialized wellness institute","RECRUITING","Isfahan","Iran","IR",{"type":79,"coordinates":80},"Point",[81,82],51.67462,32.65246,{"lat":82,"lon":81},[85],{"name":64,"role":65,"phone":86,"phoneExt":29,"email":67},"+98 913 205 1202",{"type":88,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100633383","the-effect-of-eye-exercises-in-parkinsons-disease-100633383",false,"NCT07525973","The Effect of Eye Exercises in Parkinson's Disease","The Effect of Eye Exercises on Physical Function, Balance, and Fall Risk in Patients With Parkinson's Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\nAged 18 years and older Clinically diagnosed idiopathic Parkinson's disease Hoehn and Yahr stage 1-3 Stable antiparkinsonian medication regimen Able to stand unaided and walk with or without an assistive device Able to provide written informed consent Able to attend supervised in-center exercise sessions Able to follow simple exercise instructions\n\nExclusion Criteria:\n\nSevere cognitive impairment Unstable cardiovascular, orthopedic, or neurologic conditions that interfere with safe participation Active infection or acute medical illness Hemodynamic instability Severe visual impairment or other sensory impairment that prevents participation Recent myocardial infarction or stroke Unstable or changing antiparkinsonian medication regimen Any other condition that, in the judgment of the study physician, makes participation unsafe","ALL","18 Years","80 Years",{"count":100,"type":101},34,"ESTIMATED","INTERVENTIONAL",[104],"NA","Parkinson's disease is commonly associated with impaired gait, postural instability, reduced physical function, and increased concern about falling, all of which contribute substantially to disability and reduced quality of life. Exercise-based rehabilitation is increasingly recommended as a core non-pharmacological strategy for improving mobility and balance in people with Parkinson's disease. In parallel, recent clinical and neurorehabilitation research suggests that eye-movement and gaze-stabilization training may influence postural control, visuomotor integration, and movement performance in neurological disorders, including Parkinson's disease. This randomized controlled trial will evaluate whether a supervised in-center eye-exercise program can improve physical function, balance, and fall-related concern in patients with Parkinson's disease.",[107],"Parkinson Disease",[109,110,111,112,113,114,115,116],"Parkinson disease","Eye exercises","Balance","Fall risk","Physical function","Functional mobility","Gait","Postural stability","2026-06-07",{"date":119,"type":120},"2026-06-09","ACTUAL",{"date":122,"type":120},"2026-05-01",{"date":124,"type":101},"2026-09-01",{"name":5,"class":6},1]