[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575675":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":54,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":25,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":25,"overallStatus":78,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"The Second Affiliated Hospital of Chongqing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"remimazolam for general anesthesia","EXPERIMENTAL","Remimazolam 6mg\u002Fkg\u002Fh was pumped intravenously for 2.5 min, Sufentanil 0.5 μg\u002Fkg and rocuronium 0.6mg\u002Fkg were injected intravenously, and endotracheal intubation was performed 3 minutes later. Remimazolam was then pumped at 1 mg\u002Fkg\u002Fh, the BIS was kept in the range of 40-60 through general anesthesia, and the remimazolam infusion rate was adjusted (0.5-3 mg\u002Fkg\u002Fh).If the BIS cannot be maintained at ≤ 60 or there are signs of potential inadequate anesthesia (such as cough, sweating, and patient movement), and the maximum infusion dose of remimazolam has been given, supplemental sedation with the remedial drug sevoflurane or propofol is used and the case is dismissed.",[13],"Drug: Remimazolam",{"label":15,"type":16,"description":17,"interventionNames":18},"propofol for general anesthesia","ACTIVE_COMPARATOR","Propofol (2-3mg\u002Fkg), Sufentanil (0.5μg \u002Fkg), rocuronium (0.6mg\u002Fkg) were injected intravenously, and endotracheal intubation was performed for 3 minutes. Subsequently, propofol was pumped at 4-10mg\u002Fkg\u002Fh to maintain the BIS in the range of 40-60.",[19],"Drug: propofol",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Remimazolam",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"propofol",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"He Huang H Huang","CONTACT","86+13708385559","huanghe@cqmu.edu.cn",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Ai Yan Yan","86+18716781333","guaiguai90325@126.com",[40],{"facility":5,"status":25,"city":41,"state":25,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Chongqing","400000","China","CN",{"type":46,"coordinates":47},"Point",[48,49],106.55771,29.56026,{"lat":49,"lon":48},[52],{"name":53,"role":32,"phone":33,"phoneExt":25,"email":34},"He Huang, ph.D",{"type":55,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100575675","the-effect-of-general-anesthesia-with-remimazolam-and-propofol-on-rhythmic-state-and-cognitive-function-100575675",false,"NCT06775366","The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function","Effects of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function","Inclusion Criteria:\n\nAge 18-65 years old, ASAI-III class, BMI18.5-25kg\u002Fm2 Inpatients undergoing laparoscopic cholecystectomy The estimated time of operation is 1.5\\~2.5 hours Preoperative brief mental status examination (MMSE) score ≥24 Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\nPregnant or lactating women Patients who are allergic to remimazolam or contraindicated Patients who are dependent on or tolerant to opioids or have long-term alcoholism Serious cardiovascular system, respiratory system, liver and kidney diseases History of obstructive sleep apnea mental disorders or neurological diseases Patients who participated in clinical trials of other drugs within the last 3 months The attending physician or researcher considers that there are other circumstances that are not suitable for participation in this study Refuse to participate in the study",true,"ALL","18 Years","65 Years",{"count":68,"type":69},174,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study want to observe the effects of remimazolam and propofol for general anesthesia on postoperative rhythm and cognitive function. The observation group was given remimazolam for general anesthesia, and the control group was given propofol for general anesthesia. Both drugs are commonly used as intravenous anesthetics for general anesthesia and have been shown to be safe for use in general anesthesia. The investigators hope can understand the effects of remimazolam and propofol for general anesthesia on rhythm status and cognitive function through this study, further reduce the occurrence of postoperative cognitive function impairment, and enable subjects to better recover.",[75,76,23,77],"Cognitive Functioning","Propofol","Circadian Rhythm","NOT_YET_RECRUITING","2025-02-12",{"date":81,"type":82},"2025-02-14","ACTUAL",{"date":84,"type":69},"2025-02-24",{"date":86,"type":69},"2026-05-30",{"name":5,"class":6},1]