[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509320":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":240,"collaborators":244,"id":263,"slug":264,"hasResults":265,"nctId":266,"briefTitle":267,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":265,"sex":270,"minAge":271,"maxAge":272,"enrollmentInfo":273,"targetDuration":34,"studyType":276,"phases":277,"briefSummary":279,"conditions":280,"keywords":285,"overallStatus":52,"whyStopped":34,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":298},{"fullName":5,"class":6},"Children's Hospital of Chongqing Medical University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"high caloric oral nutritional supplements group","EXPERIMENTAL","Participants aged 1 to 3 years who are malnourished (underweight and wasting). They will receive nutritional education,dietary instruction and daily high caloric oral nutritional supplements for 12 months.",[13,14,15],"Dietary Supplement: high caloric oral nutritional supplements","Behavioral: nutritional education","Behavioral: dietary guidance",{"label":17,"type":18,"description":19,"interventionNames":20},"nutritional education and dietary guidance group","ACTIVE_COMPARATOR","Participants aged 1 to 3 years who are malnourished (underweight and wasting). They will receive nutrition education and dietary instruction.",[14,15],[22,29,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIETARY_SUPPLEMENT","high caloric oral nutritional supplements","High caloric oral nutritional supplements (which can supplement 30% of the energy requirement) is given daily, and the recommended amount of energy and protein is referred to the 2013 Chinese Dietary Nutrient Reference Intake Table. At 6 months of enrollment, participants will be asked to evaluate whether to continue feeding according to the experimental group protocol or to stop to ensure proper nutritional intake.",[9],[28],"high-energy total nutrition formula",{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"BEHAVIORAL","nutritional education","After enrollment,health education information is pushed approximately every 4 weeks through the WeChat platform or\u002Fand short text messages to parents.",[9,17],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"dietary guidance","At follow-up visits at 0, 1, 2, 3, 6,and 12 months after enrollment, a professionally trained pediatrician give the participant's guardian dietary instructions appropriate to the age stage and physical condition of the child. Each session lasts approximately 10 minutes.",[9,17],[40],{"name":41,"affiliation":5,"role":42},"Li Chen, doctor","STUDY_DIRECTOR",[44],{"name":41,"role":45,"phone":46,"phoneExt":47,"email":48},"CONTACT","136 7762 0103","+86","chenli2012@126.com",[50,69,84,97,111,126,141,156,171,186,201,210,225],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Anhui Provincial Children's Hospital","RECRUITING","Hefei","Anhui","230001","China","CN",{"type":59,"coordinates":60},"Point",[61,62],117.28083,31.86389,{"lat":62,"lon":61},[65],{"name":66,"role":45,"phone":67,"phoneExt":47,"email":68},"Ya Wang, master's degree","13855150595","22891588@qq.com",{"facility":70,"status":52,"city":71,"state":72,"zip":73,"country":56,"countryCode":57,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Children's Hospital of The Capital Institute of Pediatrics","Beijing","Beijing Municipality","100020",{"type":59,"coordinates":75},[76,77],116.39723,39.9075,{"lat":77,"lon":76},[80],{"name":81,"role":45,"phone":82,"phoneExt":47,"email":83},"Lin Wang, MD","13501362346","caroldoctor@126.com",{"facility":85,"status":52,"city":86,"state":87,"zip":34,"country":56,"countryCode":57,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"The First Hospital of Jilin University","Jilin City","Changchun",{"type":59,"coordinates":89},[90,91],126.5608,43.84652,{"lat":91,"lon":90},[94],{"name":95,"role":45,"phone":96,"phoneExt":47,"email":34},"Feiyong Jia","13943003914",{"facility":98,"status":52,"city":99,"state":100,"zip":101,"country":56,"countryCode":57,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Growth, Development and Mental health of Children and Adolescence Center","Chongqing","Chongqing Municipality","400014",{"type":59,"coordinates":103},[104,105],106.55771,29.56026,{"lat":105,"lon":104},[108],{"name":109,"role":45,"phone":110,"phoneExt":47,"email":48},"Li Chen, MD","(+86)136 7762 0103",{"facility":112,"status":52,"city":113,"state":114,"zip":115,"country":56,"countryCode":57,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Guangzhou Women and Children's Medical Center","Guangzhou","Guangdong","510200",{"type":59,"coordinates":117},[118,119],113.25,23.11667,{"lat":119,"lon":118},[122],{"name":123,"role":45,"phone":124,"phoneExt":47,"email":125},"Yan Hu, master's degree","13560366657","yayayan1979@163.com",{"facility":127,"status":52,"city":128,"state":129,"zip":130,"country":56,"countryCode":57,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"Guiyang Maternity and Child Health Care Hospital","Guiyang","Guizhou","550003",{"type":59,"coordinates":132},[133,134],106.71667,26.58333,{"lat":134,"lon":133},[137],{"name":138,"role":45,"phone":139,"phoneExt":47,"email":140},"Yan Luo, MD","18585011079","718410342@qq.com",{"facility":142,"status":52,"city":143,"state":144,"zip":145,"country":56,"countryCode":57,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Hunan Children's Hospital","Changsha","Hunan","410007",{"type":59,"coordinates":147},[148,149],112.97087,28.19874,{"lat":149,"lon":148},[152],{"name":153,"role":45,"phone":154,"phoneExt":47,"email":155},"Yan Zhong, bachelor's degree","13873170189","zhongyan@163.com",{"facility":157,"status":52,"city":158,"state":159,"zip":160,"country":56,"countryCode":57,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Nanjing Maternity and Child Health Care Hospital","Nanjing","Jiangsu","210004",{"type":59,"coordinates":162},[163,164],118.77778,32.06167,{"lat":164,"lon":163},[167],{"name":168,"role":45,"phone":169,"phoneExt":47,"email":170},"Xia Chi, MD","13813875862","264601855@qq.com",{"facility":172,"status":52,"city":173,"state":174,"zip":175,"country":56,"countryCode":57,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Jiangxi Maternal and Child Health Hospital","Nanchang","Jiangxi","330006",{"type":59,"coordinates":177},[178,179],115.85306,28.68396,{"lat":179,"lon":178},[182],{"name":183,"role":45,"phone":184,"phoneExt":47,"email":185},"Ping Xu, bachelor's degree","13879112716","278938835@qq.com",{"facility":187,"status":52,"city":188,"state":189,"zip":190,"country":56,"countryCode":57,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"Baoji Maternity and Child Healthcare Hospital","Baoji","Shanxi","721000",{"type":59,"coordinates":192},[193,194],111.38866,35.90348,{"lat":194,"lon":193},[197],{"name":198,"role":45,"phone":199,"phoneExt":47,"email":200},"Xueqin Li, master's degree","15229681332","85581703@qq.com",{"facility":202,"status":52,"city":203,"state":189,"zip":204,"country":56,"countryCode":57,"cosmosGeoPoint":34,"geoPoint":34,"contacts":205},"Xianyang Children's Hospital","Xianyang","712000",[206],{"name":207,"role":45,"phone":208,"phoneExt":47,"email":209},"Hongxia Yan, bachelor's degree","15909263117","1142179306@qq.com",{"facility":211,"status":52,"city":212,"state":213,"zip":214,"country":56,"countryCode":57,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"Chengdu Women's and Children's Central Hospital，School of Medicine，University of Electronic Science and Technology of China","Chengdu","Sichuan","610091",{"type":59,"coordinates":216},[217,218],104.06667,30.66667,{"lat":218,"lon":217},[221],{"name":222,"role":45,"phone":223,"phoneExt":47,"email":224},"Lan Zhang, master's degree","13982156971","893279990@qq.com",{"facility":226,"status":52,"city":227,"state":228,"zip":229,"country":56,"countryCode":57,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"Kunming Children's Hospital","Kunming","Yunnan","650000",{"type":59,"coordinates":231},[232,233],102.71833,25.03889,{"lat":233,"lon":232},[236],{"name":237,"role":45,"phone":238,"phoneExt":47,"email":239},"Yu Ling, bachelor's degree","13888594860","lingyu@etyy.cn",{"type":241,"investigatorFullName":242,"investigatorTitle":243,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Chen Li","Associate Professor, Director",[245,246,248,250,251,252,254,255,256,257,258,259,262],{"name":51,"class":6},{"name":187,"class":247},"UNKNOWN",{"name":249,"class":6},"Chengdu Women's and Children's Central Hospital",{"name":127,"class":6},{"name":112,"class":6},{"name":142,"class":253},"OTHER_GOV",{"name":172,"class":6},{"name":226,"class":6},{"name":157,"class":6},{"name":70,"class":6},{"name":202,"class":6},{"name":260,"class":261},"Nestle Health Science","INDUSTRY",{"name":85,"class":6},"100509320","the-effect-of-high-caloric-oral-nutritional-supplements-on-growth-and-development-of-malnourished-children-100509320",false,"NCT05911893","the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children","EHCONSGDMC","Inclusion Criteria:\n\n* Aged 1-3 years\n* BMI for Age Z-score\\\u003C-2\n* Height-for-age z score\\\u003C-2\n* Total daily energy intake\\\u003C75% of recommended nutrient intake\n* The child's guardian is willing to participate in this study and sign an informed consent form.\n\nExclusion Criteria:\n\n* Chronic or severe infectious disease (e.g., chronic hepatitis, HIV or tuberculosis infection)\n* Certain congenital or genetic diseases affecting physical growth and development (congenital heart disease, Down's syndrome, infantile anorexia nervosa, etc.), malignancies and use of drugs (diuretics, appetite stimulants, steroids and growth hormones, etc.)\n* Severe gastrointestinal disorders (e.g., celiac disease, short bowel syndrome, inflammatory bowel disease, etc.)\n* Acute and chronic respiratory\u002Fdigestive tract infections within 2 weeks prior to enrollment\n* Allergy or contraindication to any of the ingredients in the high-energy total nutrition formula used in this study\n* Have used high-energy enteral nutrition preparations for the last 3 months","ALL","1 Year","3 Years",{"count":274,"type":275},200,"ESTIMATED","INTERVENTIONAL",[278],"NA","The goal of this clinical trial is to investigate the effect of high caloric oral nutritional supplements on body proportion, weight, linear growth pattern, neuropsychological development level and related health aspects (gut health, immune function, quality of life, etc.) in participants aged 1 to 3 years who are malnourished (underweight and wasting),as well as to evaluate the safety of applying high caloric oral nutritional supplements. Participants will receive nutritional education and daily high caloric oral nutritional supplements(experimental group),or will receive nutritional education and dietary instruction(control group).This study may provide data to support the development of clinical intervention strategies for malnourished Chinese children.",[281,282,283,284],"Malnutrition, Child","Malnourishment","Nutritional Deficiency","Undernutrition",[286,287,288],"Oral Nutritional Supplements","Physique Growth","Neuropsychological Development","2026-03-16",{"date":291,"type":292},"2026-03-18","ACTUAL",{"date":294,"type":292},"2024-06-17",{"date":296,"type":275},"2026-03-10",{"name":5,"class":6},13]