[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589911":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":49,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":11,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":11,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Istanbul University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intra-articular hyaluronic acid injection group","ACTIVE_COMPARATOR",null,[13],"Device: Hyaluronic Acid injections",{"label":15,"type":16,"description":11,"interventionNames":17},"Intra-articular saline injection group","PLACEBO_COMPARATOR",[18],"Other: Saline -- placebo comparator",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","Hyaluronic Acid injections","Intra-articular hyaluronic acid will be administered to 30 selected patients. Blood and synovial fluid samples will be collected before HA injection and 1 week after 3 sessions of HA injection with one week interval. Home exercise programme will be given.",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Saline -- placebo comparator","Intra-articular saline (SF) will be administered to 20 selected patients. Blood and synovial fluid samples will be collected before and 1 week after 3 session of salin injection with one week interval. Home exercise programme will be given.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Dicle Rotinda Özdaş Sevgin","CONTACT","+90 530-141-5940","rotindaozdas95@gmail.com",[36],{"facility":37,"status":38,"city":39,"state":11,"zip":11,"country":40,"countryCode":11,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Istanbul University, Istanbul Faculty of Medicine","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":42,"coordinates":43},"Point",[44,45],28.94966,41.01384,{"lat":45,"lon":44},[48],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Dicle Rotinda Ozdas Sevgin","Principal Investigator",[54],{"name":55,"class":56},"Istanbul University Research Fund","UNKNOWN","100589911","the-effect-of-hyaluronic-acid-injection-on-tnf-alpha-and-il-1-in-knee-osteoarthritis-100589911",false,"NCT06960564","The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis","Investigation of the Effect of Hyaluronic Acid Injection on Tnf-Alpha and IL-1beta at DNA-Protein Level in Knee Osteoarthritis Patients and Comparison With Clinical Parameters: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of knee osteoarthritis according to ACR (American College of Rheumatology) criteria\n* Knee pain for more than 3 months\n* Presence of knee pain resistant to conservative treatment for at least 3 months\n* To be between the ages of 45-75\n* Kellgren-Lawrence stage 2-3 gonarthrosis detected in the available knee direct radiographs of the patients\n\nExclusion Criteria:\n\n* Patients with KL stage 1 and 4 OA\n* Systematic diseases (severe cardiovascular disease, severe renal failure, severe hepatic failure, uncontrolled diabetes, cancer, immunosuppression, haematological diseases, systemic bone diseases)\n* Bleeding tendency (acquired or inherited) \\[lNR\\>2 in a patient on Coumadin\\],\n* Infection (systemic or local)\n* Secondary knee osteoarthritis (inflammatory joint disease, post-traumatic, post-infectious, etc.)\n* Major knee trauma within the last 1 year\n* BMI \\>40\n* History of total knee or hip arthroplasty within 1 year\n* Pregnancy\n* History of intra-articular injection within the last 6 months\n* Patients with Hb less than 11 g\u002Fdl and Plt less than 150.000\n* Presence of allergy to hyaluronic acid products","ALL","45 Years","75 Years",{"count":68,"type":69},50,"ESTIMATED","INTERVENTIONAL",[72],"NA","In this study, the effect of intra-articular HA injection therapy on pre- and post-treatment TNF-alpha and IL-1beta levels and methylation changes in blood and synovial fluid in patients with knee osteoarthritis will be determined and compared with the placebo group. In addition, the effects of HA injection on pain, functional status and quality of life will be evaluated and these effects will be related to changes in TNF-alpha and IL-1-beta.",[75,76],"Knee Osteoarthritis","Hyaluronic Acid","2026-01-08",{"date":79,"type":80},"2026-01-09","ACTUAL",{"date":82,"type":80},"2025-05-12",{"date":84,"type":69},"2026-03-29",{"name":5,"class":6},1]