[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642380":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":66,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Eskisehir Osmangazi University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group K","PLACEBO_COMPARATOR","Under the postoperative analgesia protocol all patients will be administered 1 gr of paracetamol at 8th 16th and 24th hours and all patients will be equipped with an IV morphine patient-controlled analgesia (PCA) device.",[13],"Drug: ISB + paracetamol IV 3*1",{"label":15,"type":16,"description":17,"interventionNames":18},"Group D","ACTIVE_COMPARATOR","Under the postoperative analgesia protocol all patients will be administered 1 gram of paracetamol at 8th 16th and 24th hours and all patients receiving nonsteroidal anti-inflammatory drugs (25 miligram of dexketroprofen) at 6th and 18th hours. The patients will be equipped with an IV morphine patient-controlled analgesia (PCA) device.",[19],"Drug: ISB+ paracetamol IV 3*1 +deksketoprofen IV 2*1",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","ISB + paracetamol IV 3*1","ISB + paracetamol IV 3\\*1",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"ISB+ paracetamol IV 3*1 +deksketoprofen IV 2*1","ISB+ paracetamol IV 3\\*1 +deksketoprofen IV 2\\*1. 25 miligram of dexketroprofen",[15],[32],{"name":33,"affiliation":34,"role":35},"MERYEM ONAY","Eskisehir Osmangazi University Faculty Of Medıcıne","STUDY_CHAIR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Çağla Uzalp","CONTACT","02222392979","caglauzalp@gmail.com",{"name":43,"role":39,"phone":40,"phoneExt":26,"email":44},"Meryem Onay","dr.meryemonay@hotmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":26,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Eskisehir Osmangazi Universıty Faculty of Medicine","RECRUITING","Eskişehir","Odunpazarı","26040","Turkey (Türkiye)",{"type":54,"coordinates":55},"Point",[56,57],30.52056,39.77667,{"lat":57,"lon":56},[60,61,64],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},{"name":62,"role":39,"phone":40,"phoneExt":26,"email":63},"Meryem onay","drmeryemonay@hotmail.com",{"name":38,"role":65,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":38,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Research assistant","100642380","the-effect-of-intravenous-dexketoprofen-on-the-severity-and-incidence-of-rebound-pain-100642380",false,"NCT07642674","The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain","Evaluation of the Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain in Patients Undergoing Interscalene Brachial Plexus Block","Inclusion Criteria:\n\nAge 18-70 years ASA score of I-III Arthroscopic shoulder surgery\n\nExclusion Criteria:\n\nPatients who do not wish to participate in the study Creatinine clearance \\\u003C50 mL\u002F min Patients for whom NSAID use is contraindicated due to heart failure, Patients with psychiatric or cognitive dysfunction that would impair their ability to assess visual analog scale (VAS) pain scores Patients for whom peripheral nerve block is contraindicated","ALL","18 Years","70 Years",{"count":79,"type":80},66,"ESTIMATED","INTERVENTIONAL",[83],"NA","Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery. In postoperative pain management, single or continue interscalene brachial plexus blocks, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids administered as needed are commonly used as components of multimodal analgesia.\n\nRebound pain is defined as severe postoperative pain (VAS ≥ 7) occurring within the first 24 hours after resolution of the block. It is considered an adverse effect of regional anesthesia and typically develops 8-12 hours after a single-shot nerve block. Risk factors for rebound pain include pre-existing pain, female sex, younger age, bone surgery, lack of intraoperative dexamethasone administration, and inadequate analgesia.\n\nThe primary objective of this study is to evaluate the effect of intravenous dexketoprofen administered during the postoperative period on the incidence and severity of rebound pain in patients undergoing shoulder surgery with interscalene brachial plexus block",[86,87,88,89],"Postoperative Pain","Pain Management","Rebound Pain","Interscalene Block",[91],"Rebaund pain, Interscalene block, postoperative pain","2026-06-11",{"date":94,"type":95},"2026-06-12","ACTUAL",{"date":92,"type":95},{"date":98,"type":80},"2027-01-01",{"name":5,"class":6},1]